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- EMDB-41040: Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG... -
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Open data
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Basic information
Entry | ![]() | |||||||||
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Title | Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG + SPL | |||||||||
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Function / homology | ![]() intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | |||||||||
Biological species | ![]() ![]() | |||||||||
Method | ![]() ![]() | |||||||||
![]() | Burtscher V / Mount J / Cowgill J / Chang Y / Bickel K / Yuan P / Chanda B | |||||||||
Funding support | ![]()
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![]() | ![]() Title: Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel Authors: Burtscher V / Mount J / Cowgill J / Chang Y / Bickel K / Yuan P / Chanda B | |||||||||
History |
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Structure visualization
Supplemental images |
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Downloads & links
-EMDB archive
Map data | ![]() | 32.8 MB | ![]() | |
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Header (meta data) | ![]() ![]() | 20.6 KB 20.6 KB | Display Display | ![]() |
FSC (resolution estimation) | ![]() | 8.5 KB | Display | ![]() |
Images | ![]() | 121.3 KB | ||
Filedesc metadata | ![]() | 6.6 KB | ||
Others | ![]() ![]() ![]() | 46.8 MB 59.3 MB 59.3 MB | ||
Archive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 8t4yMC ![]() 8t4mC ![]() 41041 C: citing same article ( M: atomic model generated by this map |
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Similar structure data | Similarity search - Function & homology ![]() |
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Links
EMDB pages | ![]() ![]() |
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Related items in Molecule of the Month |
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Map
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Projections & slices | Image control
Images are generated by Spider. | ||||||||||||||||||||||||||||||||||||
Voxel size | X=Y=Z: 1.086 Å | ||||||||||||||||||||||||||||||||||||
Density |
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Symmetry | Space group: 1 | ||||||||||||||||||||||||||||||||||||
Details | EMDB XML:
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-Supplemental data
-Additional map: #1
File | emd_41040_additional_1.map | ||||||||||||
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Projections & Slices |
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Density Histograms |
-Half map: #2
File | emd_41040_half_map_1.map | ||||||||||||
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Density Histograms |
-Half map: #1
File | emd_41040_half_map_2.map | ||||||||||||
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Density Histograms |
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Sample components
-Entire : Human HCN1 Channel
Entire | Name: Human HCN1 Channel |
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Components |
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-Supramolecule #1: Human HCN1 Channel
Supramolecule | Name: Human HCN1 Channel / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1 / Details: Homomeric Tetramer |
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Source (natural) | Organism: ![]() ![]() |
-Macromolecule #1: Potassium/sodium hyperpolarization-activated cyclic nucleotide-ga...
Macromolecule | Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 type: protein_or_peptide / ID: 1 / Number of copies: 4 / Enantiomer: LEVO |
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Source (natural) | Organism: ![]() ![]() |
Molecular weight | Theoretical: 98.839758 KDa |
Recombinant expression | Organism: ![]() ![]() |
Sequence | String: MEGGGKPNSS SNSRDDGNSV FPAKASATGA GPAAAEKRLG TPPGGGGAGA KEHGNSVCFK VDGGGGGGGG GGGGEEPAGG FEDAEGPRR QYGFMQRQFT SMLQPGVNKF SLRMFGSQKA VEKEQERVKT AGFWIIHPYS DFRFYWDLIM LIMMVGNLVI I PVGITFFT ...String: MEGGGKPNSS SNSRDDGNSV FPAKASATGA GPAAAEKRLG TPPGGGGAGA KEHGNSVCFK VDGGGGGGGG GGGGEEPAGG FEDAEGPRR QYGFMQRQFT SMLQPGVNKF SLRMFGSQKA VEKEQERVKT AGFWIIHPYS DFRFYWDLIM LIMMVGNLVI I PVGITFFT EQTTTPWIIF NVASDTVCLL DLIMNFRTGT VNEDSSEIIL DPKVIKMNYL KSWFVVDFIS SIPVDYIFLI VE KGMDSEV YKTARALRIV RFTKILCLLR LLRLSRLIRY IHQWEEIFHM TYDLASAVVR IFNLIGMMLL LAHWDGCLQF LVP LLQDFP PDCWVSLNEM VNDSWGKQYS YALFKAMSHM LCIGYGAQAP VSMSDLWITM LSMIVGATCY AMFVGHATAL IQSL DSSRR QYQEKYKQVE QYMSFHKLPA DMRQKIHDYY EHRYQGKIFD EENILNELND PLREEIVNFN CRKLVATMPL FANAD PNFV TAMLSKLRFE VFQPGDYIIR EGAVGKKMYF IQHGVAGVIT KSSKEMKLTD GSYFGEICLL TKGRRTASVR ADTYCR LYS LSVDNFNEVL EEYPMMRRAF ETVAIDRLDR IGKKNSILLQ KFQKDLNTGV FNNQENEILK QIVKHDREMV QAIAPIN YP QMTTLNSTSS TTTPTSRMRT QSPPVYTATS LSHSNLHSPS PSTQTPQPSA ILSPCSYTTA VCSPPVQSPL AARTFHYA S PTASQLSLMQ QQPQQQVQQS QPPQTQPQQP SPQPQTPGSS TPKNEVHKST QALHNTNLTR EVRPLSASQP SLPHEVSTL ISRPHPTVGE SLASIPQPVT AVPGTGLQAG GRSTVPQRVT LFRQMSSGAI PPNRGVPPAP PPPAAALPRE SSSVLNTDPD AEKPRFASN L UniProtKB: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
-Macromolecule #2: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Macromolecule | Name: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE / type: ligand / ID: 2 / Number of copies: 4 / Formula: CMP |
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Molecular weight | Theoretical: 329.206 Da |
Chemical component information | ![]() ChemComp-CMP: |
-Experimental details
-Structure determination
Method | ![]() |
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Aggregation state | particle |
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Sample preparation
Concentration | 2.5 mg/mL | |||||||||||||||||||||||||||
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Buffer | pH: 8 Component:
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Grid | Model: Quantifoil R2/2 / Material: COPPER / Mesh: 200 | |||||||||||||||||||||||||||
Vitrification | Cryogen name: ETHANE / Instrument: FEI VITROBOT MARK IV |
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Electron microscopy
Microscope | FEI TITAN KRIOS |
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Electron beam | Acceleration voltage: 300 kV / Electron source: ![]() |
Electron optics | Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD![]() |
Image recording | Film or detector model: FEI FALCON IV (4k x 4k) / Number grids imaged: 1 / Average electron dose: 53.3 e/Å2 |
Experimental equipment | ![]() Model: Titan Krios / Image courtesy: FEI Company |