EMDB-35651: human nuclear pre-60S ribosomal particle - State D'

基本情報

登録情報

データベース: EMDB / ID: EMD-35651

• タイトル: human nuclear pre-60S ribosomal particle - State D'
• マップデータ: human nuclear pre-60S ribosomal particle - State D' - post processed

試料

• 複合体: cryo-EM structure of human nuclear pre-60S ribosomal particle - State D'
  • タンパク質・ペプチド: x 55種
  • RNA: x 4種
• リガンド: x 2種

• キーワード: GNL2 / nuclear / pre-60S / RIBOSOME

機能・相同性

分子機能:

protein localization to nucleoplasm / inner cell mass cell differentiation / negative regulation of transcription of nucleolar large rRNA by RNA polymerase I / negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding / positive regulation of protein localization to chromosome, telomeric region / regulation of RIG-I signaling pathway / basal RNA polymerase II transcription machinery binding / negative regulation of collagen binding / hematopoietic stem cell homeostasis / dendrite extension / preribosome binding / regulation of cellular senescence / lamin filament / regulation of fatty acid biosynthetic process / regulation of megakaryocyte differentiation / PeBoW complex / positive regulation of protein sumoylation / miRNA-mediated post-transcriptional gene silencing / stem cell division / negative regulation of signal transduction by p53 class mediator / miRNA-mediated gene silencing by inhibition of translation / eukaryotic 80S initiation complex / positive regulation of telomere maintenance / negative regulation of protein neddylation / translation at presynapse / axial mesoderm development / ribosomal protein import into nucleus / negative regulation of formation of translation preinitiation complex / 90S preribosome assembly / blastocyst formation / positive regulation of protein K63-linked deubiquitination / protein localization to nucleolus / TORC2 complex binding / maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / skeletal system morphogenesis / GAIT complex / middle ear morphogenesis / regulation of glycolytic process / maturation of 5.8S rRNA / A band / regulation of reactive oxygen species metabolic process / alpha-beta T cell differentiation / cytoplasmic side of rough endoplasmic reticulum membrane / regulation of G1 to G0 transition / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / regulation of translation involved in cellular response to UV / protein-DNA complex disassembly / positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / negative regulation of ubiquitin protein ligase activity / regulation of aerobic respiration / response to aldosterone / stem cell population maintenance / regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of cell-cell adhesion / positive regulation of dendritic spine development / homeostatic process / rRNA metabolic process / G1 to G0 transition / negative regulation of DNA replication / macrophage chemotaxis / lung morphogenesis / Protein hydroxylation / mitotic G2 DNA damage checkpoint signaling / ribosomal large subunit binding / Peptide chain elongation / rRNA transcription / preribosome, large subunit precursor / Selenocysteine synthesis / positive regulation of signal transduction by p53 class mediator / nuclear-transcribed mRNA catabolic process / Formation of a pool of free 40S subunits / blastocyst development / ubiquitin ligase inhibitor activity / Eukaryotic Translation Termination / Response of EIF2AK4 (GCN2) to amino acid deficiency / SRP-dependent cotranslational protein targeting to membrane / negative regulation of mitotic cell cycle / Viral mRNA Translation / protein localization to nucleus / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / ribosomal large subunit export from nucleus / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / GTP hydrolysis and joining of the 60S ribosomal subunit / L13a-mediated translational silencing of Ceruloplasmin expression / somitogenesis / Major pathway of rRNA processing in the nucleolus and cytosol / protein targeting / negative regulation of protein-containing complex assembly / protein-RNA complex assembly / cellular response to interleukin-4 / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / cellular response to actinomycin D / negative regulation of ubiquitin-dependent protein catabolic process / ribonucleoprotein complex binding / ribosomal subunit export from nucleus / rough endoplasmic reticulum / MDM2/MDM4 family protein binding / negative regulation of proteasomal ubiquitin-dependent protein catabolic process / Notch signaling pathway / negative regulation of protein ubiquitination

ドメイン・相同性:

Coiled-coil domain-containing protein 86 / SDA1 domain / Uncharacterised domain NUC130/133, N-terminal / Sda1 / : / SDA1, conserved domain / SDA1, HEAT repeat / SDA1, C-terminal / MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding / FHA Ki67 binding domain of hNIFK / Learning associated protein 18-like / LLP homolog / Ribosome biogenesis protein Nop53/GLTSCR2 / Nop53 (60S ribosomal biogenesis) / Cgr1-like / Cgr1 family / : / Nucleolar GTP-binding protein 2, N-terminal domain / Nucleolar GTP-binding protein 2 / NGP1NT (NUC091) domain / NLE / NLE (NUC135) domain / Guanine nucleotide-binding protein-like 3, N-terminal domain / GNL3L/Grn1 putative GTPase / Zinc-finger double-stranded RNA-binding / Zinc finger, double-stranded RNA binding / : / Pescadillo / Pescadillo N-terminus / Ribosomal protein L24e / GTP-binding protein, orthogonal bundle domain superfamily / Ribosomal biogenesis NSA2 family / Ribosome assembly factor Mrt4 / : / BRCT domain, a BRCA1 C-terminus domain / NOG, C-terminal / Nucleolar GTP-binding protein 1 / NOGCT (NUC087) domain / Nucleolar GTP-binding protein 1, Rossman-fold domain / NOG1, N-terminal helical domain / Nucleolar GTP-binding protein 1 (NOG1) / NOG1 N-terminal helical domain / Circularly permuted (CP)-type guanine nucleotide-binding (G) domain / Circularly permuted (CP)-type guanine nucleotide-binding (G) domain profile. / Matrin/U1-C-like, C2H2-type zinc finger / U1-like zinc finger / OBG-type guanine nucleotide-binding (G) domain / OBG-type guanine nucleotide-binding (G) domain profile. / Translation initiation factor IF6 / eIF-6 family / translation initiation factor 6 / 50S ribosome-binding GTPase / Ribosomal protein L6, N-terminal / Ribosomal protein L6, N-terminal domain / Ribosomal protein L30e / GTP binding domain / Ribosomal protein L2, archaeal-type / Ribosomal L15/L27a, N-terminal / Ribosomal protein L28e / Ribosomal protein L23 / 50S ribosomal protein L10, insertion domain superfamily / Ribosomal protein L18/L18-A/B/e, conserved site / Ribosomal protein L18e signature. / Ribosomal L28e/Mak16 / Ribosomal L28e protein family / 60S ribosomal protein L10P, insertion domain / Insertion domain in 60S ribosomal protein L10P / Ribosomal protein L18e / Ribosomal protein 60S L18 and 50S L18e / metallochaperone-like domain / TRASH domain / breast cancer carboxy-terminal domain / Ribosomal protein L29e / Ribosomal L29e protein family / Ribosomal protein L13e, conserved site / Ribosomal protein L13e signature. / Ribosomal protein L22e / Ribosomal protein L22e superfamily / Ribosomal L22e protein family / Ribosomal protein L38e / Ribosomal protein L38e superfamily / Ribosomal L38e protein family / Ribosomal protein L27e, conserved site / Ribosomal protein L27e signature. / Ribosomal protein L13e / Ribosomal protein L13e / Ribosomal protein L19, eukaryotic / 60S ribosomal protein L18a/ L20, eukaryotes / Ribosomal protein L24e, conserved site / Ribosomal protein L19/L19e conserved site / Ribosomal protein L19e signature. / Ribosomal protein L24e signature. / Ribosomal protein L34e, conserved site / Ribosomal protein L34e signature. / Ribosomal protein L1, 3-layer alpha/beta-sandwich / Ribosomal protein L5 eukaryotic, C-terminal / Ribosomal L18 C-terminal region / : / Ribosomal protein L30e signature 1. / Ribosomal protein L6e signature.

構成要素:

Zinc finger protein 593 / Pescadillo homolog / Ribosomal L1 domain-containing protein 1 / Ribosome biogenesis protein NSA2 homolog / Large ribosomal subunit protein eL33 / Large ribosomal subunit protein uL30 / Large ribosomal subunit protein uL22 / Large ribosomal subunit protein eL13 / Large ribosomal subunit protein uL11 / Large ribosomal subunit protein uL6 / Large ribosomal subunit protein eL22 / Large ribosomal subunit protein uL4 / Large ribosomal subunit protein uL3 / Large ribosomal subunit protein uL13 / Large ribosomal subunit protein uL29 / Large ribosomal subunit protein uL15 / Large ribosomal subunit protein uL18 / Large ribosomal subunit protein eL21 / Large ribosomal subunit protein eL28 / Large ribosomal subunit protein eL29 / Large ribosomal subunit protein eL34 / Large ribosomal subunit protein eL14 / Eukaryotic translation initiation factor 6 / Large ribosomal subunit protein uL24 / Large ribosomal subunit protein eL15 / Large ribosomal subunit protein eL27 / Large ribosomal subunit protein eL43 / Large ribosomal subunit protein eL37 / Large ribosomal subunit protein eL8 / Large ribosomal subunit protein uL23 / Large ribosomal subunit protein uL14 / Large ribosomal subunit protein eL30 / Large ribosomal subunit protein eL39 / Large ribosomal subunit protein eL31 / Large ribosomal subunit protein eL32 / Large ribosomal subunit protein uL5 / Large ribosomal subunit protein uL2 / Large ribosomal subunit protein eL38 / Large ribosomal subunit protein eL19 / Large ribosomal subunit protein eL20 / Large ribosomal subunit protein eL6 / Large ribosomal subunit protein eL18 / Nucleolar GTP-binding protein 2 / Ribosomal protein uL30-like / Protein LLP homolog / Guanine nucleotide-binding protein-like 3 / MKI67 FHA domain-interacting nucleolar phosphoprotein / GTP-binding protein 4 / Coiled-coil domain-containing protein 86 / Protein SDA1 homolog / Notchless protein homolog 1 / Ribosome biogenesis protein NOP53 / Probable ribosome biogenesis protein RLP24 / mRNA turnover protein 4 homolog / Large ribosomal subunit protein eL36

• 生物種: Homo sapiens (ヒト)
• 手法: 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.2 Å
• データ登録者: Zhang Y / Gao N

資金援助

中国, 1件

Organization	Grant number	国
National Science Foundation (NSF, China)	32230051;31922036	中国

• 引用: ジャーナル: Cell Res / 年: 2023; タイトル: Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.; 著者: Yunyang Zhang / Xiaomeng Liang / Sha Luo / Yan Chen / Yu Li / Chengying Ma / Ningning Li / Ning Gao / ; 要旨: Eukaryotic ribosome assembly is a highly orchestrated process that involves over two hundred protein factors. After early assembly events on nascent rRNA in the nucleolus, pre-60S particles undergo continuous maturation steps in the nucleoplasm, and prepare for nuclear export. Here, we report eleven cryo-EM structures of the nuclear pre-60S particles isolated from human cells through epitope-tagged GNL2, at resolutions of 2.8-4.3 Å. These high-resolution snapshots provide fine details for several major structural remodeling events at a virtual temporal resolution. Two new human nuclear factors, L10K and C11orf98, were also identified. Comparative structural analyses reveal that many assembly factors act as successive place holders to control the timing of factor association/dissociation events. They display multi-phasic binding properties for different domains and generate complex binding inter-dependencies as a means to guide the rRNA maturation process towards its mature conformation. Overall, our data reveal that nuclear assembly of human pre-60S particles is generally hierarchical with short branch pathways, and a few factors display specific roles as rRNA chaperones by confining rRNA helices locally to facilitate their folding, such as the C-terminal domain of SDAD1.

履歴

登録	2023年3月15日	-
ヘッダ(付随情報) 公開	2023年8月9日	-
マップ公開	2023年8月9日	-
更新	2023年11月15日	-
現状	2023年11月15日	処理サイト: PDBj / 状態: 公開

マップ

• ファイル: ダウンロード / ファイル: emd_35651.map.gz / 形式: CCP4 / 大きさ: 244.1 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• 注釈: human nuclear pre-60S ribosomal particle - State D' - post processed
• ボクセルのサイズ: X=Y=Z: 1.37 Å

密度

表面レベル	登録者による: 0.032
最小 - 最大	-0.073731035 - 0.2109689
平均 (標準偏差)	0.0008076142 (±0.005799573)

• 対称性: 空間群: 1

詳細

EMDB XML:

マップ形状	Axis order X Y Z Origin 0 0 0 サイズ 400 400 400 Spacing 400 400 400
セル	A=B=C: 548.0 Å α=β=γ: 90.0 °

添付データ

ハーフマップ: human nuclear pre-60S ribosomal particle - State D' - half1

• ファイル: emd_35651_half_map_1.map
• 注釈: human nuclear pre-60S ribosomal particle - State D' - half1

ハーフマップ: human nuclear pre-60S ribosomal particle - State D' - half2

• ファイル: emd_35651_half_map_2.map
• 注釈: human nuclear pre-60S ribosomal particle - State D' - half2

試料の構成要素

全体 : cryo-EM structure of human nuclear pre-60S ribosomal particle - S...

• 全体: 名称: cryo-EM structure of human nuclear pre-60S ribosomal particle - State D'

要素

• 複合体: cryo-EM structure of human nuclear pre-60S ribosomal particle - State D'
  • タンパク質・ペプチド: Protein SDA1 homolog
  • RNA: 28S rRNA
  • タンパク質・ペプチド: Eukaryotic translation initiation factor 6
  • タンパク質・ペプチド: Probable ribosome biogenesis protein RLP24
  • RNA: 5.8S rRNA
  • タンパク質・ペプチド: Zinc finger protein 593
  • タンパク質・ペプチド: 60S ribosomal protein L29
  • タンパク質・ペプチド: 60S ribosomal protein L3
  • タンパク質・ペプチド: 60S ribosomal protein L4
  • タンパク質・ペプチド: 60S ribosomal protein L30
  • タンパク質・ペプチド: 60S ribosomal protein L7a
  • タンパク質・ペプチド: 60S ribosomal protein L35
  • タンパク質・ペプチド: 60S ribosomal protein L9
  • タンパク質・ペプチド: Ribosome biogenesis protein NSA2 homolog
  • タンパク質・ペプチド: 60S ribosomal protein L27a
  • タンパク質・ペプチド: 60S ribosomal protein L37
  • タンパク質・ペプチド: 60S ribosomal protein L39
  • タンパク質・ペプチド: 60S ribosomal protein L13
  • タンパク質・ペプチド: 60S ribosomal protein L14
  • タンパク質・ペプチド: 60S ribosomal protein L15
  • タンパク質・ペプチド: 60S ribosomal protein L13a
  • タンパク質・ペプチド: 60S ribosomal protein L37a
  • タンパク質・ペプチド: 60S ribosomal protein L18
  • タンパク質・ペプチド: 60S ribosomal protein L19
  • タンパク質・ペプチド: 60S ribosomal protein L18a
  • タンパク質・ペプチド: 60S ribosomal protein L23
  • タンパク質・ペプチド: 60S ribosomal protein L26
  • タンパク質・ペプチド: 60S ribosomal protein L28
  • タンパク質・ペプチド: 60S ribosomal protein L8
  • タンパク質・ペプチド: 60S ribosomal protein L35a
  • タンパク質・ペプチド: 60S ribosomal protein L6
  • タンパク質・ペプチド: 60S ribosomal protein L7
  • タンパク質・ペプチド: Coiled-coil domain-containing protein 86
  • タンパク質・ペプチド: Guanine nucleotide-binding protein-like 3
  • タンパク質・ペプチド: mRNA turnover protein 4 homolog
  • タンパク質・ペプチド: G Protein Nucleolar 2
  • タンパク質・ペプチド: 60S ribosomal protein L12
  • タンパク質・ペプチド: Protein LLP homolog
  • タンパク質・ペプチド: 60S ribosomal protein L11
  • タンパク質・ペプチド: 60S ribosomal protein L5
  • タンパク質・ペプチド: Notchless protein homolog 1
  • タンパク質・ペプチド: 60S ribosomal protein L21
  • タンパク質・ペプチド: GTP-binding protein 4
  • タンパク質・ペプチド: 60S ribosomal protein L17
  • タンパク質・ペプチド: 60S ribosomal protein L32
  • タンパク質・ペプチド: 60S ribosomal protein L31
  • タンパク質・ペプチド: 60S ribosomal protein L22
  • タンパク質・ペプチド: MKI67 FHA domain-interacting nucleolar phosphoprotein
  • RNA: ITS2
  • タンパク質・ペプチド: Ribosomal L1 domain-containing protein 1
  • タンパク質・ペプチド: 60S ribosomal protein L7-like 1
  • タンパク質・ペプチド: Pescadillo homolog
  • タンパク質・ペプチド: 60S ribosomal protein L23a
  • タンパク質・ペプチド: 60S ribosomal protein L36
  • タンパク質・ペプチド: 60S ribosomal protein L34
  • タンパク質・ペプチド: 60S ribosomal protein L27
  • タンパク質・ペプチド: 60S ribosomal protein L38
  • タンパク質・ペプチド: Ribosome biogenesis protein NOP53
  • RNA: 5S rRNA
• リガンド: GUANOSINE-5'-TRIPHOSPHATE
• リガンド: MAGNESIUM ION

超分子 #1: cryo-EM structure of human nuclear pre-60S ribosomal particle - S...

• 超分子: 名称: cryo-EM structure of human nuclear pre-60S ribosomal particle - State D'; タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: #1-#51, #57-#58, #52-#55, #59, #56
• 由来(天然): 生物種: Homo sapiens (ヒト)

分子 #1: Protein SDA1 homolog

• 分子: 名称: Protein SDA1 homolog / タイプ: protein_or_peptide / ID: 1 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 80.005492 KDa

配列

文字列:

MSNRNNNKLP SNLPQLQNLI KRDPPAYIEE FLQQYNHYKS NVEIFKLQPN KPSKELAELV MFMAQISHCY PEYLSNFPQE VKDLLSCNH TVLDPDLRMT FCKALILLRN KNLINPSSLL ELFFELFRCH DKLLRKTLYT HIVTDIKNIN AKHKNNKVNV V LQNFMYTM LRDSNATAAK MSLDVMIELY RRNIWNDAKT VNVITTACFS KVTKILVAAL TFFLGKDEDE KQDSDSESED DG PTARDLL VQYATGKKSS KNKKKLEKAM KVLKKQKKKK KPEVFNFSAI HLIHDPQDFA EKLLKQLECC KERFEVKMML MNL ISRLVG IHELFLFNFY PFLQRFLQPH QREVTKILLF AAQASHHLVP PEIIQSLLMT VANNFVTDKN SGEVMTVGIN AIKE ITARC PLAMTEELLQ DLAQYKTHKD KNVMMSARTL IHLFRTLNPQ MLQKKFRGKP TEASIEARVQ EYGELDAKDY IPGAE VLEV EKEENAENDE DGWESTSLSE EEDADGEWID VQHSSDEEQQ EISKKLNSMP MEERKAKAAA ISTSRVLTQE DFQKIR MAQ MRKELDAAPG KSQKRKYIEI DSDEEPRGEL LSLRDIERLH KKPKSDKETR LATAMAGKTD RKEFVRKKTK TNPFSSS TN KEKKKQKNFM MMRYSQNVRS KNKRSFREKQ LALRDALLKK RKRMK

UniProtKB: Protein SDA1 homolog

分子 #3: Eukaryotic translation initiation factor 6

• 分子: 名称: Eukaryotic translation initiation factor 6 / タイプ: protein_or_peptide / ID: 3 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 26.62001 KDa

配列

文字列:

MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNSLP DTVQIRRVEE RLSALGNVTT CNDYVALVHP DLDRETEEIL ADVLKVEVFR QTVADQVLVG SYCVFSNQGG L VHPKTSIE DQDELSSLLQ VPLVAGTVNR GSEVIAAGMV VNDWCAFCGL DTTSTELSVV ESVFKLNEAQ PSTIATSMRD SL IDSLT

UniProtKB: Eukaryotic translation initiation factor 6

分子 #4: Probable ribosome biogenesis protein RLP24

• 分子: 名称: Probable ribosome biogenesis protein RLP24 / タイプ: protein_or_peptide / ID: 4 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 19.666258 KDa

配列

文字列:

MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR WTKAFRKAAG KELTVDNSFE FEKRRNEPIK YQRELWNKT IDAMKRVEEI KQKRQAKFIM NRLKKNKELQ KVQDIKEVKQ NIHLIRAPLA GKGKQLEEKM VQQLQEDVDM E DAP

UniProtKB: Probable ribosome biogenesis protein RLP24

分子 #6: Zinc finger protein 593

• 分子: 名称: Zinc finger protein 593 / タイプ: protein_or_peptide / ID: 6 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 15.230225 KDa

配列

文字列:

MGRSRRTGAH RAHSLARQMK AKRRRPDLDE IHRELRPQGS ARPQPDPNAE FDPDLPGGGL HRCLACARYF IDSTNLKTHF RSKDHKKRL KQLSVEPYSQ EEAERAAGMG SYVPPRRLAV PTEVSTEVPE MDTST

UniProtKB: Zinc finger protein 593

分子 #7: 60S ribosomal protein L29

• 分子: 名称: 60S ribosomal protein L29 / タイプ: protein_or_peptide / ID: 7 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 17.804275 KDa

配列

文字列:

MAKSKNHTTH NQSRKWHRNG IKKPRSQRYE SLKGVDPKFL RNMRFAKKHN KKGLKKMQAN NAKAMSARAE AIKALVKPKE VKPKIPKGV SRKLDRLAYI AHPKLGKRAR ARIAKGLRLC RPKAKAKAKA KDQTKAQAAA PASVPAQAPK RTQAPTKASE

UniProtKB: Large ribosomal subunit protein eL29

分子 #8: 60S ribosomal protein L3

• 分子: 名称: 60S ribosomal protein L3 / タイプ: protein_or_peptide / ID: 8 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 46.211113 KDa

配列

文字列:

MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDPSKP VHLTAFLGYK AGMTHIVREV DRPGSKVNKK EVVEAVTIVE TPPMVVVGI VGYVETPRGL RTFKTVFAEH ISDECKRRFY KNWHKSKKKA FTKYCKKWQD EDGKKQLEKD FSSMKKYCQV I RVIAHTQM RLLPLRQKKA HLMEIQVNGG TVAEKLDWAR ERLEQQVPVN QVFGQDEMID VIGVTKGKGY KGVTSRWHTK KL PRKTHRG LRKVACIGAW HPARVAFSVA RAGQKGYHHR TEINKKIYKI GQGYLIKDGK LIKNNASTDY DLSDKSINPL GGF VHYGEV TNDFVMLKGC VVGTKKRVLT LRKSLLVQTK RRALEKIDLK FIDTTSKFGH GRFQTMEEKK AFMGPLKKDR IAKE EGA

UniProtKB: Large ribosomal subunit protein uL3

分子 #9: 60S ribosomal protein L4

• 分子: 名称: 60S ribosomal protein L4 / タイプ: protein_or_peptide / ID: 9 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 47.804621 KDa

配列

文字列:

MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQ GAFGNMCRGG RMFAPTKTWR RWHRRVNTTQ KRYAICSALA ASALPALVMS KGHRIEEVPE LPLVVEDKVE G YKKTKEAV LLLKKLKAWN DIKKVYASQR MRAGKGKMRN RRRIQRRGPC IIYNEDNGII KAFRNIPGIT LLNVSKLNIL KL APGGHVG RFCIWTESAF RKLDELYGTW RKAASLKSNY NLPMHKMINT DLSRILKSPE IQRALRAPRK KIHRRVLKKN PLK NLRIML KLNPYAKTMR RNTILRQARN HKLRVDKAAA AAAALQAKSD EKAAVAGKKP VVGKKGKKAA VGVKKQKKPL VGKK AAATK KPAPEKKPAE KKPTTEEKKP AA

UniProtKB: Large ribosomal subunit protein uL4

分子 #10: 60S ribosomal protein L30

• 分子: 名称: 60S ribosomal protein L30 / タイプ: protein_or_peptide / ID: 10 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 12.805092 KDa

配列

文字列:

MVAAKKTKKS LESINSRLQL VMKSGKYVLG YKQTLKMIRQ GKAKLVILAN NCPALRKSEI EYYAMLAKTG VHHYSGNNIE LGTACGKYY RVCTLAIIDP GDSDIIRSMP EQTGEK

UniProtKB: Large ribosomal subunit protein eL30

分子 #11: 60S ribosomal protein L7a

• 分子: 名称: 60S ribosomal protein L7a / タイプ: protein_or_peptide / ID: 11 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 30.061785 KDa

配列

文字列:

MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDR QTATQLLKLA HKYRPETKQE KKQRLLARAE KKAAGKGDVP TKRPPVLRAG VNTVTTLVEN KKAQLVVIAH D VDPIELVV FLPALCRKMG VPYCIIKGKA RLGRLVHRKT CTTVAFTQVN SEDKGALAKL VEAIRTNYND RYDEIRRHWG GN VLGPKSV ARIAKLEKAK AKELATKLG

UniProtKB: Large ribosomal subunit protein eL8

分子 #12: 60S ribosomal protein L35

• 分子: 名称: 60S ribosomal protein L35 / タイプ: protein_or_peptide / ID: 12 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 14.593624 KDa

配列

文字列:

MAKIKARDLR GKKKEELLKQ LDDLKVELSQ LRVAKVTGGA ASKLSKIRVV RKSIARVLTV INQTQKENLR KFYKGKKYKP LDLRPKKTR AMRRRLNKHE ENLKTKKQQR KERLYPLRKY AVKA

UniProtKB: Large ribosomal subunit protein uL29

分子 #13: 60S ribosomal protein L9

• 分子: 名称: 60S ribosomal protein L9 / タイプ: protein_or_peptide / ID: 13 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 21.899471 KDa

配列

文字列:

MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK KKKRLRVDKW WGNRKELATV RTICSHVQNM IKGVTLGFR YKMRSVYAHF PINVVIQENG SLVEIRNFLG EKYIRRVRMR PGVACSVSQA QKDELILEGN DIELVSNSAA L IQQATTVK NKDIRKFLDG IYVSEKGTVQ QADE

UniProtKB: Large ribosomal subunit protein uL6

分子 #14: Ribosome biogenesis protein NSA2 homolog

• 分子: 名称: Ribosome biogenesis protein NSA2 homolog / タイプ: protein_or_peptide / ID: 14 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 30.136703 KDa

配列

文字列:

MPQNEYIELH RKRYGYRLDY HEKKRKKESR EAHERSKKAK KMIGLKAKLY HKQRHAEKIQ MKKTIKMHEK RNTKQKNDEK TPQGAVPAY LLDREGQSRA KVLSNMIKQK RKEKAGKWEV PLPKVRAQGE TEVLKVIRTG KRKKKAWKRM VTKVCFVGDG F TRKPPKYE RFIRPMGLRF KKAHVTHPEL KATFCLPILG VKKNPSSPLY TTLGVITKGT VIEVNVSELG LVTQGGKVIW GK YAQVTNN PENDGCINAV LLV

UniProtKB: Ribosome biogenesis protein NSA2 homolog

分子 #15: 60S ribosomal protein L27a

• 分子: 名称: 60S ribosomal protein L27a / タイプ: protein_or_peptide / ID: 15 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 16.604535 KDa

配列

文字列:

MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGLHH HRINFDKYHP GYFGKVGMKH YHLKRNQSFC PTVNLDKLWT LVSEQTRVN AAKNKTGAAP IIDVVRSGYY KVLGKGKLPK QPVIVKAKFF SRRAEEKIKS VGGACVLVA

UniProtKB: Large ribosomal subunit protein uL15

分子 #16: 60S ribosomal protein L37

• 分子: 名称: 60S ribosomal protein L37 / タイプ: protein_or_peptide / ID: 16 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 11.111032 KDa

配列

文字列:

MTKGTSSFGK RRNKTHTLCR RCGSKAYHLQ KSTCGKCGYP AKRKRKYNWS AKAKRRNTTG TGRMRHLKIV YRRFRHGFRE GTTPKPKRA AVAASSSS

UniProtKB: Large ribosomal subunit protein eL37

分子 #17: 60S ribosomal protein L39

• 分子: 名称: 60S ribosomal protein L39 / タイプ: protein_or_peptide / ID: 17 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 6.426759 KDa

配列

文字列:

MSSHKTFRIK RFLAKKQKQN RPIPQWIRMK TGNKIRYNSK RRHWRRTKLG L

UniProtKB: Large ribosomal subunit protein eL39

分子 #18: 60S ribosomal protein L13

• 分子: 名称: 60S ribosomal protein L13 / タイプ: protein_or_peptide / ID: 18 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 24.321682 KDa

配列

文字列:

MAPSRNGMVL KPHFHKDWQR RVATWFNQPA RKIRRRKARQ AKARRIAPRP ASGPIRPIVR CPTVRYHTKV RAGRGFSLEE LRVAGIHKK VARTIGISVD PRRRNKSTES LQANVQRLKE YRSKLILFPR KPSAPKKGDS SAEELKLATQ LTGPVMPVRN V YKKEKARV ITEEEKNFKA FASLRMARAN ARLFGIRAKR AKEAAEQDVE KKK

UniProtKB: Large ribosomal subunit protein eL13

分子 #19: 60S ribosomal protein L14

• 分子: 名称: 60S ribosomal protein L14 / タイプ: protein_or_peptide / ID: 19 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 23.485016 KDa

配列

文字列:

MVFRRFVEVG RVAYVSFGPH AGKLVAIVDV IDQNRALVDG PCTQVRRQAM PFKCMQLTDF ILKFPHSAHQ KYVRQAWQKA DINTKWAAT RWAKKIEARE RKAKMTDFDR FKVMKAKKMR NRIIKNEVKK LQKAALLKAS PKKAPGTKGT AAAAAAAAAA K VPAKKITA ASKKAPAQKV PAQKATGQKA APAPKAQKGQ KAPAQKAPAP KASGKKA

UniProtKB: Large ribosomal subunit protein eL14

分子 #20: 60S ribosomal protein L15

• 分子: 名称: 60S ribosomal protein L15 / タイプ: protein_or_peptide / ID: 20 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 24.207285 KDa

配列

文字列:

MGAYKYIQEL WRKKQSDVMR FLLRVRCWQY RQLSALHRAP RPTRPDKARR LGYKAKQGYV IYRIRVRRGG RKRPVPKGAT YGKPVHHGV NQLKFARSLQ SVAEERAGRH CGALRVLNSY WVGEDSTYKF FEVILIDPFH KAIRRNPDTQ WITKPVHKHR E MRGLTSAG RKSRGLGKGH KFHHTIGGSR RAAWRRRNTL QLHRYR

UniProtKB: Large ribosomal subunit protein eL15

分子 #21: 60S ribosomal protein L13a

• 分子: 名称: 60S ribosomal protein L13a / タイプ: protein_or_peptide / ID: 21 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 23.633412 KDa

配列

文字列:

MAEVQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF WRTVRGMLP HKTKRGQAAL DRLKVFDGIP PPYDKKKRMV VPAALKVVRL KPTRKFAYLG RLAHEVGWKY QAVTATLEEK R KEKAKIHY RKKKQLMRLR KQAEKNVEKK IDKYTEVLKT HGLLV

UniProtKB: Large ribosomal subunit protein uL13

分子 #22: 60S ribosomal protein L37a

• 分子: 名称: 60S ribosomal protein L37a / タイプ: protein_or_peptide / ID: 22 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 10.29935 KDa

配列

文字列:

MAKRTKKVGI VGKYGTRYGA SLRKMVKKIE ISQHAKYTCS FCGKTKMKRR AVGIWHCGSC MKTVAGGAWT YNTTSAVTVK SAIRRLKEL KDQ

UniProtKB: Large ribosomal subunit protein eL43

分子 #23: 60S ribosomal protein L18

• 分子: 名称: 60S ribosomal protein L18 / タイプ: protein_or_peptide / ID: 23 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 21.687676 KDa

配列

文字列:

MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR LFMSRTNRPP LSLSRMIRKM KLPGRENKTA VVVGTITDD VRVQEVPKLK VCALRVTSRA RSRILRAGGK ILTFDQLALD SPKGCGTVLL SGPRKGREVY RHFGKAPGTP H SHTKPYVR SKGRKFERAR GRRASRGYKN

UniProtKB: Large ribosomal subunit protein eL18

分子 #24: 60S ribosomal protein L19

• 分子: 名称: 60S ribosomal protein L19 / タイプ: protein_or_peptide / ID: 24 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 23.535281 KDa

配列

文字列:

MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI IRKPVTVHSR ARCRKNTLAR RKGRHMGIGK RKGTANARM PEKVTWMRRM RILRRLLRRY RESKKIDRHM YHSLYLKVKG NVFKNKRILM EHIHKLKADK ARKKLLADQA E ARRSKTKE ARKRREERLQ AKKEEIIKTL SKEEETKK

UniProtKB: Large ribosomal subunit protein eL19

分子 #25: 60S ribosomal protein L18a

• 分子: 名称: 60S ribosomal protein L18a / タイプ: protein_or_peptide / ID: 25 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 20.808514 KDa

配列

文字列:

MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSG THNMYREYRD LTTAGAVTQC YRDMGARHRA RAHSIQIMKV EEIAASKCRR PAVKQFHDSK IKFPLPHRVL R RQHKPRFT TKRPNTFF

UniProtKB: Large ribosomal subunit protein eL20

分子 #26: 60S ribosomal protein L23

• 分子: 名称: 60S ribosomal protein L23 / タイプ: protein_or_peptide / ID: 26 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 14.892505 KDa

配列

文字列:

MSKRGRGGSS GAKFRISLGL PVGAVINCAD NTGAKNLYII SVKGIKGRLN RLPAAGVGDM VMATVKKGKP ELRKKVHPAV VIRQRKSYR RKDGVFLYFE DNAGVIVNNK GEMKGSAITG PVAKECADLW PRIASNAGSI A

UniProtKB: Large ribosomal subunit protein uL14

分子 #27: 60S ribosomal protein L26

• 分子: 名称: 60S ribosomal protein L26 / タイプ: protein_or_peptide / ID: 27 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 17.303363 KDa

配列

文字列:

MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREK ANGTTVHVGI HPSKVVITRL KLDKDRKKIL ERKAKSRQVG KEKGKYKEET IEKMQE

UniProtKB: Large ribosomal subunit protein uL24

分子 #28: 60S ribosomal protein L28

• 分子: 名称: 60S ribosomal protein L28 / タイプ: protein_or_peptide / ID: 28 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 15.784622 KDa

配列

文字列:

MSAHLQWMVV RNCSSFLIKR NKQTYSTEPN NLKARNSFRY NGLIHRKTVG VEPAADGKGV VVVIKRRSGQ RKPATSYVRT TINKNARAT LSSIRHMIRK NKYRPDLRMA AIRRASAILR SQKPVMVKRK RTRPTKSS

UniProtKB: Large ribosomal subunit protein eL28

分子 #29: 60S ribosomal protein L8

• 分子: 名称: 60S ribosomal protein L8 / タイプ: protein_or_peptide / ID: 29 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 28.088863 KDa

配列

文字列:

MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH DPGRGAPLAK VVFRDPYRFK KRTELFIAAE GIHTGQFVY CGKKAQLNIG NVLPVGTMPE GTIVCCLEEK PGDRGKLARA SGNYATVISH NPETKKTRVK LPSGSKKVIS S ANRAVVGV VAGGGRIDKP ILKAGRAYHK YKAKRNCWPR VRGVAMNPVE HPFGGGNHQH IGKPSTIRRD APAGRKVGLI AA RRTGRLR GTKTVQEKEN

UniProtKB: Large ribosomal subunit protein uL2

分子 #30: 60S ribosomal protein L35a

• 分子: 名称: 60S ribosomal protein L35a / タイプ: protein_or_peptide / ID: 30 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 12.564743 KDa

配列

文字列:

MSGRLWSKAI FAGYKRGLRN QREHTALLKI EGVYARDETE FYLGKRCAYV YKAKNNTVTP GGKPNKTRVI WGKVTRAHGN SGMVRAKFR SNLPAKAIGH RIRVMLYPSR I

UniProtKB: Large ribosomal subunit protein eL33

分子 #31: 60S ribosomal protein L6

• 分子: 名称: 60S ribosomal protein L6 / タイプ: protein_or_peptide / ID: 31 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 32.810176 KDa

配列

文字列:

MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGIGRYSRS AMYSRKAMYK RKYSAAKSKV EKKKKEKVL ATVTKPVGGD KNGGTRVVKL RKMPRYYPTE DVPRKLLSHG KKPFSQHVRK LRASITPGTI LIILTGRHRG K RVVFLKQL ASGLLLVTGP LVLNRVPLRR THQKFVIATS TKIDISNVKI PKHLTDAYFK KKKLRKPRHQ EGEIFDTEKE KY EITEQRK IDQKAVDSQI LPKIKAIPQL QGYLRSVFAL TNGIYPHKLV F

UniProtKB: Large ribosomal subunit protein eL6

分子 #32: 60S ribosomal protein L7

• 分子: 名称: 60S ribosomal protein L7 / タイプ: protein_or_peptide / ID: 32 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 29.290973 KDa

配列

文字列:

MEGVEEKKKE VPAVPETLKK KRRNFAELKI KRLRKKFAQK MLRKARRKLI YEKAKHYHKE YRQMYRTEIR MARMARKAGN FYVPAEPKL AFVIRIRGIN GVSPKVRKVL QLLRLRQIFN GTFVKLNKAS INMLRIVEPY IAWGYPNLKS VNELIYKRGY G KINKKRIA LTDNALIARS LGKYGIICME DLIHEIYTVG KRFKEANNFL WPFKLSSPRG GMKKKTTHFV EGGDAGNRED QI NRLIRRM N

UniProtKB: Large ribosomal subunit protein uL30

分子 #33: Coiled-coil domain-containing protein 86

• 分子: 名称: Coiled-coil domain-containing protein 86 / タイプ: protein_or_peptide / ID: 33 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 40.312742 KDa

配列

文字列:

MDTPLRRSRR LGGLRPESPE SLTSVSRTRR ALVEFESNPE ETREPGSPPS VQRAGLGSPE RPPKTSPGSP RLQQGAGLES PQGQPEPGA ASPQRQQDLH LESPQRQPEY SPESPRCQPK PSEEAPKCSQ DQGVLASELA QNKEELTPGA PQHQLPPVPG S PEPYPGQQ APGPEPSQPL LELTPRAPGS PRGQHEPSKP PPAGETVTGG FGAKKRKGSS SQAPASKKLN KEELPVIPKG KP KSGRVWK DRSKKRFSQM LQDKPLRTSW QRKMKERQER KLAKDFARHL EEEKERRRQE KKQRRAENLK RRLENERKAE VVQ VIRNPA KLKRAKKKQL RSIEKRDTLA LLQKQPPQQP AAKI

UniProtKB: Coiled-coil domain-containing protein 86

分子 #34: Guanine nucleotide-binding protein-like 3

• 分子: 名称: Guanine nucleotide-binding protein-like 3 / タイプ: protein_or_peptide / ID: 34 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 62.098242 KDa

配列

文字列:

MKRPKLKKAS KRMTCHKRYK IQKKVREHHR KLRKEAKKRG HKKPRKDPGV PNSAPFKEAL LREAELRKQR LEELKQQQKL DRQKELEKK RKLETNPDIK PSNVEPMEKE FGLCKTENKA KSGKQNSKKL YCQELKKVIE ASDVVLEVLD ARDPLGCRCP Q VEEAIVQS GQKKLVLILN KSDLVPKENL ESWLNYLKKE LPTVVFRAST KPKDKGKITK RVKAKKNAAP FRSEVCFGKE GL WKLLGGF QETCSKAIRV GVIGFPNVGK SSIINSLKQE QMCNVGVSMG LTRSMQVVPL DKQITIIDSP SFIVSPLNSS SAL ALRSPA SIEVVKPMEA ASAILSQADA RQVVLKYTVP GYRNSLEFFT VLAQRRGMHQ KGGIPNVEGA AKLLWSEWTG ASLA YYCHP PTSWTPPPYF NESIVVDMKS GFNLEELEKN NAQSIRAIKG PHLANSILFQ SSGLTNGIIE EKDIHEELPK RKERK QEER EDDKDSDQET VDEEVDENSS GMFAAEETGE ALSEETTAGE QSTRSFILDK IIEEDDAYDF STDYV

UniProtKB: Guanine nucleotide-binding protein-like 3

分子 #35: mRNA turnover protein 4 homolog

• 分子: 名称: mRNA turnover protein 4 homolog / タイプ: protein_or_peptide / ID: 35 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 27.602535 KDa

配列

文字列:

MPKSKRDKKV SLTKTAKKGL ELKQNLIEEL RKCVDTYKYL FIFSVANMRN SKLKDIRNAW KHSRMFFGKN KVMMVALGRS PSDEYKDNL HQVSKRLRGE VGLLFTNRTK EEVNEWFTKY TEMDYARAGN KAAFTVSLDP GPLEQFPHSM EPQLRQLGLP T ALKRGVVT LLSDYEVCKE GDVLTPEQAR VLKLFGYEMA EFKVTIKYMW DSQSGRFQQM GDDLPESASE STEESDSEDD D

UniProtKB: mRNA turnover protein 4 homolog

分子 #36: G Protein Nucleolar 2

• 分子: 名称: G Protein Nucleolar 2 / タイプ: protein_or_peptide / ID: 36 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 83.796094 KDa

配列

文字列:

MVKPKYKGRS TINPSKASTN PDRVQGAGGQ NMRDRATIRR LNMYRQKERR NSRGKIIKPL QYQSTVASGT VARVEPNIKW FGNTRVIKQ SSLQKFQEEM DTVMKDPYKV VMKQSKLPMS LLHDRIRPHN LKVHILDTES FETTFGPKSQ RKRPNLFASD M QSLIENAE MSTESYDQGK DRDLVTEDTG VRNEAQEEIY KKGQSKRIWG ELYKVIDSSD VVVQVLDARD PMGTRSPHIE TY LKKEKPW KHLIFVLNKC DLVPTWATKR WVAVLSQDYP TLAFHASLTN PFGKGAFIQL LRQFGKLHTD KKQISVGFIG YPN VGKSSV INTLRSKKVC NVAPIAGETK VWQYITLMRR IFLIDCPGVV YPSEDSETDI VLKGVVQVEK IKSPEDHIGA VLER AKPEY ISKTYKIDSW ENAEDFLEKL AFRTGKLLKG GEPDLQTVGK MVLNDWQRGR IPFFVKPPNA EPLVAPQLLP SSSLE VVPE AAQNNPGEEV TETAGEGSES IIKEETEENS HCDANTEMQQ ILTRVRQNFG KINVVPQFSG DDLVPVEVSD LEEELE SFS DEEEEEQEQQ RDDAEESSSE PEEENVGNDT KAVIKALDEK IAKYQKFLDK AKAKKFSAVR ISKGLSEKIF AKPEEQR KT LEEDVDDRAP SKKGKKRKAQ REEEQEHSNK APRALTSKER RRAVRQQRPK KVGVRYYETH NVKNRNRNKK KTNDSEGQ K HKRKKFRQKQ

UniProtKB: Nucleolar GTP-binding protein 2

分子 #37: 60S ribosomal protein L12

• 分子: 名称: 60S ribosomal protein L12 / タイプ: protein_or_peptide / ID: 37 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 17.847619 KDa

配列

文字列:

MPPKFDPNEI KVVYLRCTGG EVGATSALAP KIGPLGLSPK KVGDDIAKAT GDWKGLRITV KLTIQNRQAQ IEVVPSASAL IIKALKEPP RDRKKQKNIK HSGNITFDEI VNIARQMRHR SLARELSGTI KEILGTAQSV GCNVDGRHPH DIIDDINSGA V ECPAS

UniProtKB: Large ribosomal subunit protein uL11

分子 #38: Protein LLP homolog

• 分子: 名称: Protein LLP homolog / タイプ: protein_or_peptide / ID: 38 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 15.268361 KDa

配列

文字列:

MAKSLRSKWK RKMRAEKRKK NAPKEASRLK SILKLDGDVL MKDVQEIATV VVPKPKHCQE KMQCEVKDEK DDMKMETDIK RNKKTLLDQ HGQYPIWMNQ RQRKRLKAKR EKRKGKSKAK AVKVAKGLAW

UniProtKB: Protein LLP homolog

分子 #39: 60S ribosomal protein L11

• 分子: 名称: 60S ribosomal protein L11 / タイプ: protein_or_peptide / ID: 39 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 20.288465 KDa

配列

文字列:

MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF SKARYTVRSF GIRRNEKIAV HCTVRGAKAE EILEKGLKV REYELRKNNF SDTGNFGFGI QEHIDLGIKY DPSIGIYGLD FYVVLGRPGF SIADKKRRTG CIGAKHRISK E EAMRWFQQ KYDGIILPGK

UniProtKB: Large ribosomal subunit protein uL5

分子 #40: 60S ribosomal protein L5

• 分子: 名称: 60S ribosomal protein L5 / タイプ: protein_or_peptide / ID: 40 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 34.426789 KDa

配列

文字列:

MGFVKVVKNK AYFKRYQVKF RRRREGKTDY YARKRLVIQD KNKYNTPKYR MIVRVTNRDI ICQIAYARIE GDMIVCAAYA HELPKYGVK VGLTNYAAAY CTGLLLARRL LNRFGMDKIY EGQVEVTGDE YNVESIDGQP GAFTCYLDAG LARTTTGNKV F GALKGAVD GGLSIPHSTK RFPGYDSESK EFNAEVHRKH IMGQNVADYM RYLMEEDEDA YKKQFSQYIK NSVTPDMMEE MY KKAHAAI RENPVYEKKP KKEVKKKRWN RPKMSLAQKK DRVAQKKASF LRAQERAAES

UniProtKB: Large ribosomal subunit protein uL18

分子 #41: Notchless protein homolog 1

• 分子: 名称: Notchless protein homolog 1 / タイプ: protein_or_peptide / ID: 41 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 53.387141 KDa

配列

文字列:

MAAAVPDEAV ARDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDRLQLVCNA LLAQEDPLPL AFFVHDAEIV SSLGKTLESQ AVETEKVLD IIYQPQAIFR VRAVTRCTSS LEGHSEAVIS VAFSPTGKYL ASGSGDTTVR FWDLSTETPH FTCKGHRHWV L SISWSPDG RKLASGCKNG QILLWDPSTG KQVGRTLAGH SKWITGLSWE PLHANPECRY VASSSKDGSV RIWDTTAGRC ER ILTGHTQ SVTCLRWGGD GLLYSASQDR TIKVWRAHDG VLCRTLQGHG HWVNTMALST DYALRTGAFE PAEASVNPQD LQG SLQELK ERALSRYNLV RGQGPERLVS GSDDFTLFLW SPAEDKKPLT RMTGHQALIN QVLFSPDSRI VASASFDKSI KLWD GRTGK YLASLRGHVA AVYQIAWSAD SRLLVSGSSD STLKVWDVKA QKLAMDLPGH ADEVYAVDWS PDGQRVASGG KDKCL RIWR R

UniProtKB: Notchless protein homolog 1

分子 #42: 60S ribosomal protein L21

• 分子: 名称: 60S ribosomal protein L21 / タイプ: protein_or_peptide / ID: 42 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 18.609988 KDa

配列

文字列:

MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK GMPHKCYHGK TGRVYNVTQH AVGIVVNKQV KGKILAKRI NVRIEHIKHS KSRDSFLKRV KENDQKKKEA KEKGTWVQLK RQPAPPREAH FVRTNGKEPE LLEPIPYEFM A

UniProtKB: Large ribosomal subunit protein eL21

分子 #43: GTP-binding protein 4

• 分子: 名称: GTP-binding protein 4 / タイプ: protein_or_peptide / ID: 43 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 74.10782 KDa

配列

文字列:

MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK VKFTQQNYHD RLSQILTDFP KLDDIHPFYA DLMNILYDK DHYKLALGQI NIAKNLVDNV AKDYVRLMKY GDSLYRCKQL KRAALGRMCT VIKRQKQSLE YLEQVRQHLS R LPTIDPNT RTLLLCGYPN VGKSSFINKV TRADVDVQPY AFTTKSLFVG HMDYKYLRWQ VVDTPGILDH PLEDRNTIEM QA ITALAHL RAAVLYVMDL SEQCGHGLRE QLELFQNIRP LFINKPLIVV ANKCDVKRIA ELSEDDQKIF TDLQSEGFPV IET STLTEE GVIKVKTEAC DRLLAHRVET KMKGNKVNEV LNRLHLAIPT RRDDKERPPF IPEGVVARRK RMETEESRKK RERD LELEM GDDYILDLQK YWDLMNLSEK HDKIPEIWEG HNIADYIDPA IMKKLEELEK EEELRTAAGE YDSVSESEDE EMLEI RQLA KQIREKKKLK ILESKEKNTQ GPRMPRTAKK VQRTVLEKEM RSLGVDMDDK DDAHYAVQAR RSRSITRKRK REDSAP PSS VARSGSCSRT PRDVSGLRDV KMVKKAKTMM KNAQKKMNRL GKKGEADRHV FDMKPKHLLS GKRKAGKKDR R

UniProtKB: GTP-binding protein 4

分子 #44: 60S ribosomal protein L17

• 分子: 名称: 60S ribosomal protein L17 / タイプ: protein_or_peptide / ID: 44 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 21.44317 KDa

配列

文字列:

MVRYSLDPEN PTKSCKSRGS NLRVHFKNTR ETAQAIKGMH IRKATKYLKD VTLQKQCVPF RRYNGGVGRC AQAKQWGWTQ GRWPKKSAE FLLHMLKNAE SNAELKGLDV DSLVIEHIQV NKAPKMRRRT YRAHGRINPY MSSPCHIEMI LTEKEQIVPK P EEEVAQKK KISQKKLKKQ KLMARE

UniProtKB: Large ribosomal subunit protein uL22

分子 #45: 60S ribosomal protein L32

• 分子: 名称: 60S ribosomal protein L32 / タイプ: protein_or_peptide / ID: 45 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 15.898932 KDa

配列

文字列:

MAALRPLVKP KIVKKRTKKF IRHQSDRYVK IKRNWRKPRG IDNRVRRRFK GQILMPNIGY GSNKKTKHML PSGFRKFLVH NVKELEVLL MCNKSYCAEI AHNVSSKNRK AIVERAAQLA IRVTNPNARL RSEENE

UniProtKB: Large ribosomal subunit protein eL32

分子 #46: 60S ribosomal protein L31

• 分子: 名称: 60S ribosomal protein L31 / タイプ: protein_or_peptide / ID: 46 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 14.494938 KDa

配列

文字列:

MAPAKKGGEK KKGRSAINEV VTREYTINIH KRIHGVGFKK RAPRALKEIR KFAMKEMGTP DVRIDTRLNK AVWAKGIRNV PYRIRVRLS RKRNEDEDSP NKLYTLVTYV PVTTFKNLQT VNVDEN

UniProtKB: Large ribosomal subunit protein eL31

分子 #47: 60S ribosomal protein L22

• 分子: 名称: 60S ribosomal protein L22 / タイプ: protein_or_peptide / ID: 47 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 14.813015 KDa

配列

文字列:

MAPVKKLVVK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN GKAGNLGGGV VTIERSKSKI TVTSEVPFSK RYLKYLTKK YLKKNNLRDW LRVVANSKES YELRYFQINQ DEEEEEDED

UniProtKB: Large ribosomal subunit protein eL22

分子 #48: MKI67 FHA domain-interacting nucleolar phosphoprotein

• 分子: 名称: MKI67 FHA domain-interacting nucleolar phosphoprotein; タイプ: protein_or_peptide / ID: 48 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 34.285309 KDa

配列

文字列:

MATFSGPAGP ILSLNPQEDV EFQKEVAQVR KRITQRKKQE QLTPGVVYVR HLPNLLDETQ IFSYFSQFGT VTRFRLSRSK RTGNSKGYA FVEFESEDVA KIVAETMNNY LFGERLLECH FMPPEKVHKE LFKDWNIPFK QPSYPSVKRY NRNRTLTQKL R MEERFKKK ERLLRKKLAK KGIDYDFPSL ILQKTESISK TNRQTSTKGQ VLRKKKKKVS GTLDTPEKTV DSQGPTPVCT PT FLERRKS QVAELNDDDK DDEIVFKQPI SCVKEEIQET QTPTHSRKKR RRSSNQ

UniProtKB: MKI67 FHA domain-interacting nucleolar phosphoprotein

分子 #50: Ribosomal L1 domain-containing protein 1

• 分子: 名称: Ribosomal L1 domain-containing protein 1 / タイプ: protein_or_peptide / ID: 50 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 55.08975 KDa

配列

文字列:

MEDSASASLS SAAATGTSTS TPAAPTARKQ LDKEQVRKAV DALLTHCKSR KNNYGLLLNE NESLFLMVVL WKIPSKELRV RLTLPHSIR SDSEDICLFT KDEPNSTPEK TEQFYRKLLN KHGIKTVSQI ISLQTLKKEY KSYEAKLRLL SSFDFFLTDA R IRRLLPSL IGRHFYQRKK VPVSVNLLSK NLSREINDCI GGTVLNISKS GSCSAIRIGH VGMQIEHIIE NIVAVTKGLS EK LPEKWES VKLLFVKTEK SAALPIFSSF VSNWDEATKR SLLNKKKKEA RRKRRERNFE KQKERKKKRQ QARKTASVLS KDD VAPESG DTTVKKPESK KEQTPEHGKK KRGRGKAQVK ATNESEDEIP QLVPIGKKTP ANEKVEIQKH ATGKKSPAKS PNPS TPRGK KRKALPASET PKAAESETPG KSPEKKPKIK EEAVKEKSPS LGKKDARQTP KKPEAKFFTT PSKSVRKASH TPKKW PKKP KVPQST

UniProtKB: Ribosomal L1 domain-containing protein 1

分子 #51: 60S ribosomal protein L7-like 1

• 分子: 名称: 60S ribosomal protein L7-like 1 / タイプ: protein_or_peptide / ID: 51 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 29.730354 KDa

配列

文字列:

MISSCTTRKM AEQEQRKIPL VPENLLKKRK AYQALKATQA KQALLAKKEQ KKGKGLRFKR LESFLHDSWR QKRDKVRLRR LEVKPHALE LPDKHSLAFV VRIERIDGVS LLVQRTIARL RLKKIFSGVF VKVTPQNLKM LRIVEPYVTW GFPNLKSVRE L ILKRGQAK VKNKTIPLTD NTVIEEHLGK FGVICLEDLI HEIAFPGKHF QEISWFLCPF HLSVARHATK NRVGFLKEMG TP GYRGERI NQLIRQLN

UniProtKB: Ribosomal protein uL30-like

分子 #52: 60S ribosomal protein L36

• 分子: 名称: 60S ribosomal protein L36 / タイプ: protein_or_peptide / ID: 52 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 12.290859 KDa

配列

文字列:

MALRYPMAVG LNKGHKVTKN VSKPRHSRRR GRLTKHTKFV RDMIREVCGF APYERRAMEL LKVSKDKRAL KFIKKRVGTH IRAKRKREE LSNVLAAMRK AAAKKD

UniProtKB: Large ribosomal subunit protein eL36

分子 #53: 60S ribosomal protein L34

• 分子: 名称: 60S ribosomal protein L34 / タイプ: protein_or_peptide / ID: 53 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 13.326074 KDa

配列

文字列:

MVQRLTYRRR LSYNTASNKT RLSRTPGNRI VYLYTKKVGK APKSACGVCP GRLRGVRAVR PKVLMRLSKT KKHVSRAYGG SMCAKCVRD RIKRAFLIEE QKIVVKVLKA QAQSQKAK

UniProtKB: Large ribosomal subunit protein eL34

分子 #54: 60S ribosomal protein L27

• 分子: 名称: 60S ribosomal protein L27 / タイプ: protein_or_peptide / ID: 54 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 15.835831 KDa

配列

文字列:

MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP RKVTAAMGKK KIAKRSKIKS FVKVYNYNHL MPTRYSVDI PLDKTVVNKD VFRDPALKRK ARREAKVKFE ERYKTGKNKW FFQKLRF

UniProtKB: Large ribosomal subunit protein eL27

分子 #55: 60S ribosomal protein L38

• 分子: 名称: 60S ribosomal protein L38 / タイプ: protein_or_peptide / ID: 55 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 8.238948 KDa

配列

文字列:

MPRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK EKAEKLKQSL PPGLAVKELK

UniProtKB: Large ribosomal subunit protein eL38

分子 #57: Pescadillo homolog

• 分子: 名称: Pescadillo homolog / タイプ: protein_or_peptide / ID: 57 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 68.114727 KDa

配列

文字列:

MGGLEKKKYE RGSATNYITR NKARKKLQLS LADFRRLCIL KGIYPHEPKH KKKVNKGSTA ARTFYLIKDI RFLLHEPIVN KFREYKVFV RKLRKAYGKS EWNTVERLKD NKPNYKLDHI IKERYPTFID ALRDLDDALS MCFLFSTFPR TGKCHVQTIQ L CRRLTVEF MHYIIAARAL RKVFLSIKGI YYQAEVLGQP IVWITPYAFS HDHPTDVDYR VMATFTEFYT TLLGFVNFRL YQ LLNLHYP PKLEGQAQAE AKAGEGTYAL DSESCMEKLA ALSASLARVV VPATEEEAEV DEFPTDGEMS AQEEDRRKEL EAQ EKHKKL FEGLKFFLNR EVPREALAFI IRSFGGEVSW DKSLCIGATY DVTDSRITHQ IVDRPGQQTS VIGRCYVQPQ WVFD SVNAR LLLPVAEYFS GVQLPPHLSP FVTEKEGDYV PPEKLKLLAL QRGEDPGNLN ESEEEEEEDD NNEGDGDEEG ENEEE EEDA EAGSEKEEEA RLAALEEQRM EGKKPRVMAG TLKLEDKQRL AQEEESEAKR LAIMMMKKRE KYLYQKIMFG KRRKIR EAN KLAEKRKAHD EAVRSEKKAK KARPE

UniProtKB: Pescadillo homolog

分子 #58: 60S ribosomal protein L23a

• 分子: 名称: 60S ribosomal protein L23a / タイプ: protein_or_peptide / ID: 58 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 17.740193 KDa

配列

文字列:

MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKK IEDNNTLVFI VDVKANKHQI KQAVKKLYDI DVAKVNTLIR PDGEKKAYVR LAPDYDALDV ANKIGII

UniProtKB: Large ribosomal subunit protein uL23

分子 #59: Ribosome biogenesis protein NOP53

• 分子: 名称: Ribosome biogenesis protein NOP53 / タイプ: protein_or_peptide / ID: 59 / コピー数: 1 / 光学異性体: LEVO
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 54.498402 KDa

配列

文字列:

MAAGGSGVGG KRSSKSDADS GFLGLRPTSV DPALRRRRRG PRNKKRGWRR LAQEPLGLEV DQFLEDVRLQ ERTSGGLLSE APNEKLFFV DTGSKEKGLT KKRTKVQKKS LLLKKPLRVD LILENTSKVP APKDVLAHQV PNAKKLRRKE QLWEKLAKQG E LPREVRRA QARLLNPSAT RAKPGPQDTV ERPFYDLWAS DNPLDRPLVG QDEFFLEQTK KKGVKRPARL HTKPSQAPAV EV APAGASY NPSFEDHQTL LSAAHEVELQ RQKEAEKLER QLALPATEQA ATQESTFQEL CEGLLEESDG EGEPGQGEGP EAG DAEVCP TPARLATTEK KTEQQRRREK AVHRLRVQQA ALRAARLRHQ ELFRLRGIKA QVALRLAELA RRQRRRQARR EAEA DKPRR LGRLKYQAPD IDVQLSSELT DSLRTLKPEG NILRDRFKSF QRRNMIEPRE RAKFKRKYKV KLVEKRAFRE IQL

UniProtKB: Ribosome biogenesis protein NOP53

分子 #2: 28S rRNA

• 分子: 名称: 28S rRNA / タイプ: rna / ID: 2 / 詳細: NCBI Reference Sequence: NR_146154.1 / コピー数: 1
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 1.6364385 MDa

配列

文字列:

CGCGACCUCA GAUCAGACGU GGCGACCCGC UGAAUUUAAG CAUAUUAGUC AGCGGAGGAG AAGAAACUAA CCAGGAUUCC CUCAGUAAC GGCGAGUGAA CAGGGAAGAG CCCAGCGCCG AAUCCCCGCC CCGCGGCGGG GCGCGGGACA UGUGGCGUAC G GAAGACCC GCUCCCCGGC GCCGCUCGUG GGGGGCCCAA GUCCUUCUGA UCGAGGCCCA GCCCGUGGAC GGUGUGAG (B9B) CCGGUAGCGG CCCCCGGCGC GCCGGGCCCG GGUCUUCCCG GAGUCGGGUU GCUUGGGAAU GCAGCCCAAA GCGGG UGGU AAACUCCAUC UAAGGCUAAA UACCGGCACG AGACCGAUAG UCAACAAGUA CCGUAA(OMG)GGA AAGUUGAAAA GA ACUUUGA AG(A2M)GAGAGUU CAAGAGGGCG UGAAACCGUU AAGAGGUAAA CGGGUGGGGU CCGCGCAGUC CGCCCGGAG GAUUCAACCC GGCGGCGGGU CCGGCCGUGU CGGCGGCCCG GCGGAUCUUU CCCGCCCCCC GUUCCUCCCG ACCCCUCCAC CCGCCCUCC CUUCCCCCGC CGCCCCUCCU CCUCCUCCCC GGAGGGGGCG GGCUCCGGCG GGUGCGGGGG UGGGCGGGCG G GGCCGGGG GUGGGGUCGG CGGGGGACCG UCCCCCGACC GGCGACCGGC CGCCGCCGGG CGCAUUUCCA CCGCGGCGGU GC GCCGCGA CCGGCUCCGG GACGGCU(2MG)GG AAGGCCCGGC GGGGAAGGUG GCUCGGGGGG CCCCGUCCGU CCGUCCGUC CGUCCUCCUC CUCCCCCGUC UCCGCCCCCC GGCCCCGCGU CCUCCCUCGG GAGGGCGCGC GGGUCGGGGC GGCGGCGGCG GCGGCGGUG GCGGCGGCGG CGGCGGCGGC GGGACCGAAA CCCCCCCCGA GUGUUACAGC CCCCCCGGCA GCAGCACUCG C CGAAUCCC GGGGCCGAGG GAGCGAGACC CGUCGCCGC(2MG) CUCUCCCCCC UCCCGGCGCC CACCCCCGCG GGGAAUCC C CCGCGAGGGG GGUCUCCCCC GCGGGGGCGC GCCGGCGUCU CCUCGUGGGG GGGCCGGGCC ACCCCUCCCA CGGCGCGAC CGCUCUCCCA CCCCUCCUCC CCGCGCCCCC GCCCCGGCGA CGGGGGGGGU GCCGCGCGCG GGUCGGGGGG CGGGGCGGAC UGUCCCCAG UGCGCCCCGG GCGGGUCGCG CCGUCGGGCC CGGGGGAGGU UCUCUCGGGG CCACGCGCGC GUCCCCCGAA G AGGGGGAC GGCGGAGCGA GCGCACGGGG UCGGCGGCGA CGUCGGCUAC CCACCCGACC C(OMG)UCUUGAAA C(A2M)CG GACCA AGGAGUCUAA CACG(P4U)GCGCG AGUCGGGGGC UCGCACGAAA GCCGCCGUGG CGCAAUGAAG GUGAAGGCCG G CGCGCUCG CCGGCCGAGG UGGGAUCCCG AGGCCUCUCC AGUCCGCCGA GGG(B8Q)GCACCA CCGGCCCGUC UCGCCCGC C GCGCCGGGGA GGUGGAGCAC GAGCGCACGU GUUAG(2MG)ACCC (OMG)A(A2M)AGAUGGU GA(A2M)CUAUGCC UGG GCAGGG CGAAGCCAGA GGAAACUCUG GUG(B9B)AGGUCC GUAGCGGUCC UGACGUGCAA AUCG(7MG)UCGUC CGACCU GGG UAUAG(OMG)GGCG AAAGACUAAU CGAACCAUCU AGUAGCUGG(I4U) UCCCUCCGAA GUUUCCCUCA GGAUAGCUG GCGCUCUCGC AGACCCGACG CACCCCCGCC ACGCAGUUUU AUCCGGUAAA GCGAAUGAUU AGAGGUCUUG GGGCCGAAAC GAUCUCAAC CUAUUCUCAA ACUUUAAAUG GGUAAGAAGC CCGGCUCGCU GGCGUGGAGC CGGGCGUGGA AUGCGAGUGC C UAGUGGGC CACUUUUGGU AAGC(A2M)GAACU GGCGCU(OMG)CGG GAUGAACCGA ACGCCGGGUU AA(P7G)GCGCCCG AUGCCGACG CUCAUCAGAC CCCAGAAAAG GUGUUGGUUG AUAUAGACAG CAGGACGGUG GCCAUGGAAG UCGGAAUCCG C UAAGGAGU GUGUAACAAC UCACCUGCCG AAUCAACUAG CCCUGAAAAU GGAUG(OMG)CGCU GGAGCGUCGG GCCCAUAC C CGGCCGUCGC CGGCAGUCGA GAGUGGACGG GAGCGGCGGC GGCGGCGCGC GCGCGCGCGC GUGUGGUGUG CGUCGGAGG GCGGCGGCGG CGGCGGCGGC GGGGGUGUGG GGUCCUUCCC CCGCCCCCCC CCCCACGCCU CCUCCCCUCC UCCCGCCCAC GCCCCGCUC CCCGCCCCCG GAGCCCCGCG GACGCUACGC CGCGACGAGU AGGAGGGCCG CUGCG(E7G)UGAG CCUUGAA GC CUAGGGCGCG GGCCCGGGUG GAGCCGCCGC AGGUGCAGAU CUUGGUGGUA GU(A2M)(OMG)(OMC)AAAUA UUCAAA CGA (B8W)AACUUUGAA GGCCGAAGUG G(A2M)GAAGGGUU CCAUGUGAAC AG(OMC)A(OMG)UUGAA CAUGGGUCAG U CGGUCCUG AGAGAUGGGC GAGCGCCGUU CCGAAGGGAC GGGCGAUGGC CUCCGUUGCC CUCGGCCGAU CGAAAGGGAG UC G(7MG)GUUCA GAUCCCCGAA UCCGGAGUGG CGGAGAUGGG CGCCGCGAGG CGUCCAGUGC GGUAACGCGA CCGAUCCCG GAGAAGCCGG CGGGAGCCCC GGGGAGAGUU CUCUUUUCUU UGUGAAGGGC AGGGCGCCCU GGAAUGGGUU CGCCCCGAGA GAGGGGCCC GUGCCUUGGA AAGCGUCGCG GUUCCGGCGG CGUCCGGUGA GCUCUCGCUG GCCCUUGAAA AUCCGGGG (B9B) AGAGGGUGUA AAUCUCGC(OMG)C CGGGCCGUAC C(B9H)AUAUCCGC AGCAGGUCU(OMC) CAAGGUGAAC AGC CUCUGG CAUGUUGGAA CAAUGUAGGU AAGGGAAGUC GGCAAGC(OMC)GG AUCCGUAACU UCGGGAUAAG GAUUGGCUCU AAGGGCUGG GUCGGUCGGG CUGGGGCGCG AAGCGGGGCU GGGCGCGCGC CGCGGCUGGA CGAGGCGCCG CCGCCCCCCC C ACGCCCGG GGCACCCCCC UCGCGGCCCU CCCCCGCCCC ACCCCGCGCG CGCCGCUCGC UCCCUCCCCG CCCCGCGCCC UC UCUCUCU CUCUCUCCCC CGCUCCCCGU CCUCCCCCCU CCCCGGGGGA GCGCCGCGUG GGGGCGGCGG CGGGGGGAGA AGG GUCGGG GCGGCAGGGG CCGGCGGCGG CCCGCCGCGG GGCCCCGGCG GCGGGGGCAC GGUCCCCCGC GAGGGGGGCC CGGG CACCC GGGGGGCCGG CGGCGGCGGC GACUCUGGAC GCGAGCCGGG CCCUUCCCGU GGAUCGCCCC AGCUGCGGCG GGCGU CGCG GCCGCCCCCG GGGAGCCCGG CGGGCGCCGG CGCGCCCCCC CCCCCACCCC ACGUCUCGUC GCGCGCGCGU CCGCUG GGG GCGGGGAGCG GUCGGGCGGC GGCGGUCGGC GGGCGGCGGG GCGGGGCGGU UCGUCCCCCC GCCCUACCCC CCCGGCC CC GUCCGCCCCC CGUUCCCCCC UCCUCCUCGG CGCGCGGCGG CGGCGGCGGC AGGCGGCGGA GGGGCCGCGG GCCGGUCC C CCCCGCCGGG UCCGCCCCCG GGGCCGCGGU UCCGCGCGGC GCCUCGCCUC GGCCGGCGCC UAGCAGCCGA CUUAGAACU GGUGCGGACC AGGGGAAUCC GACUGUUUAA UUAAAACAAA GCAUCGCGAA GGCCCGCGGC GGGUGUUGAC GCGAUGUGAU UUCUGCC(OMC)A GUGCUCUGAA UGUCA(A2M)AGUG (A2M)AGAAAUUCA AUGAAGCGCG GGUAAACGGC GGGAGUAAC UAUGACUCUC UUAAGGUAGC CAAAUGCCUC GUCAUCUAAU UAGUGACGCG CAUGAAUGGA UGA(A2M)CGAGAU UCCCAC UGU CCCUACCUAC UAUCCAGCGA AACCAC(A2M)G(OMC)C AAGGGAACG(P7G) GCUUGG(OMC)GGA AUCAGC(B8K) G(BGH) GAAAGAAGA(OMC) CCUGUUGAGC UUGACUCUAG UCUGGCACGG UGAAGAGACA UGAGAGGUGU AGAAUAAGUG GGAGGCCCC CGGCGCCCCC CCGGUGUCCC CGCGAGGGGC CCGGGGCGGG GUCCGCCGGC CCUGCGGGCC GCCGGUGAAA U ACCACUAC UCUGAUCGUU UUUUCACUGA CCCGG(5MU)GAGG CGGGGGGGCG AGCCCCGAGG GGCUCUCGCU UCUGGCGC C AAGCGCCCGG CCGCGCGCCG GCCGGGCGCG ACCCGCUCCG GGGACAGUGC CAGGUGGG(B8W)A GUUUGACUG(OMG) G GCGGUACA CCUGUCAAAC GGUA(6MZ)CGCAG GUGUCCUAAG GCGAGCUCAG GGAGGACAGA AACCUCCCGU GGAGCAGA A GGGCAAAAGC UCGCUUGAUC UUGAUUUUCA GUACGAAUAC AGACCGUGAA AGCGGGGCCU (5MC)ACGAUCCUU CUGAC CUUU UGGGUUUUAA GCAGGAGGUG UCAGAAAAGU UACCACAGGG AUAACUGGCU UGUGGCGGCC AAGCGUUCAU AGCGAC GUC GCUUUUUGAU CCUUCGAUGU CGGCUCUUCC UAUCAUUGU(B8W) AAGCAGAAUU (B8T)ACCAAGCGU U(OMG)GAU UGUU CACCCACUAA UAGGGAACGU G(A2M)GCUGG(B8W)(UR3)U UAGA(OMC)CGUCG UGAGACAG(7MG)U UAGUUU UAC CCU(M7A)CUGAUG (A2M)UGUGUUGUU GCCAUGGUAA UCCUGC(UR3)CAG UACGAGAGGA ACCGCAGGU(OMU) C A(OMG)ACAUUU GGUGUAU(OMG)UG CUUGGCUGAG GAGCCAAUGG GGCGAAGCUA C(B8T)AUCUGUGG GAUUAUGACU (B8K)AACGCCUC UAAGUCAGAA UCCCGCCCAG GCGGAACGAU ACGGCAGCGC CGCGGAGCCU CGGUUGGCCU CGGAUAG CC GGUCCCCCGG GCCGCCCCCC CCCUCCACGC GCCCCGCGCG CGCGGGAGGG CGCGUGCCCC GCCGCGCGCC GGGACCGG G GUCCGGU(OMG)C(2MG) GAGUGCCCUU CGUCCUGGGA AACGGGGCGC GGCCGGAGAG GCGGCCGCCC CCUCGCCCGU C ACGCACCG CACGUUCGUG GGGAACCUGG CGCUAAACCA UUCGUAGACG ACCUGCUUCU GGGUCGGGGU UUCGUACGUA GC AGAGCAG CUCCCUCGCU GCGAUCUAUU GAAAGUCAGC CCUCGACACA AGGGUUUGUC

分子 #5: 5.8S rRNA

• 分子: 名称: 5.8S rRNA / タイプ: rna / ID: 5 / コピー数: 1
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 50.157676 KDa

配列

文字列:

CGACUCUUAG CGG(OMU)GGAUCA CUCGGCUCGU GCGUCGAUGA AGAACGCAGC UAGCUGCGAG AAUUAAUGUG AAUUGC AGG ACACAUUGAU CAUCGACACU UCGAACGCAC UUGCGGCCCC GGGUUCCUCC CGGGGCUACG CCUGUCUGAG CGUCGCU

GENBANK: GENBANK: KY962518.1

分子 #49: ITS2

• 分子: 名称: ITS2 / タイプ: rna / ID: 49 ; 詳細: X17626.1: gccgatcaatcgccccgggggtgcctccgggctcctcggggtgcgcggctgggggttccctcgcagggcccgccgggggccctccgtccccctaagcgcagacccggcggcgtccgccctcctcttgccgccgcgcccgccccttccccctccccccgcgggccctgcgtggtcacgcgtcgggtggcgggggggagaggggggcgcgcccggctgagagagacggggagggcggcgccgccgccggaagacggagagggaaagagagagccggctcgggccgagttcccgtggccgccgcctgcggtccgggttcctccctcggggggctccctcgcgccgcgcgcggctcggggttcggggttcgtcggccccggccgggtggaaggtcccgtgcccgtcgtcgtcgtcgtcgcgcgtcgtcggcggtgggggcgtgttgcgtgcggtgtggtggtgggggaggaggaaggcgggtccggaaggggaagggtgccggcggggagagagggtcgggggagcgcgtcccggtcgccgcggttccgccgcccgcccccggtggcggcccggcgtccggccgaccggccgctccccgcgcccctcctcctccccgccgcccctcctccgaggccccgcccgtcctcctcgccctccccgcgcgtacgcgcgcgcgcccgcccgcccggctcgcctcgcggcgcgtcggccggggccgggagcccgccccgccgcccgcccgtggccgcggcgccggggttcgcgtgtccccggcggcgacccgcgggacgccgcggtgtcgtccgccgtcgcgcgcccgcctccggctcgcggccgcgccgcgccgcgccggggccccgtcccgagcttccgcgtcggggcggcgcggctccgccgccgcgtcctcggacccgtccccccgacctccgcgggggagacgcgccggggcgtgcggcgcccgtcccgcccccggcccgtgcccctccctccggtcgtcccgctccggcggggcggcgcgggggcgccgtcggccgcgcgctctctctcccgtcgcctctccccctcgccgggcccgtctcccgacggagcgtcgggcgggcggtcgggccggcgcgattccgtccgtccgtccgccgagcggcccgtccccctccgaga; コピー数: 1
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 31.330174 KDa

配列

文字列:

(N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N) (N)(N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N) (N)(N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N)(N) (N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N)(N) (N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N)(N)(N)(N)(N)(N)(N)(N)(N)(N) (N) (N)(N)(N)(N)

分子 #56: 5S rRNA

• 分子: 名称: 5S rRNA / タイプ: rna / ID: 56 / コピー数: 1
• 由来(天然): 生物種: Homo sapiens (ヒト)
• 分子量: 理論値: 38.651887 KDa

配列

文字列:

GUCUACGGCC AUACCACCCU GAACGCGCCC GAUCUCGUCU GAUCUCGGAA GCUAAGCAGG GUCGGGCCUG GUUAGUACUU GGAUGGGAG ACCCGCCUGG AAUACCGGGU GCUGUAGGCU U

分子 #60: GUANOSINE-5'-TRIPHOSPHATE

• 分子: 名称: GUANOSINE-5'-TRIPHOSPHATE / タイプ: ligand / ID: 60 / コピー数: 1 / 式: GTP
• 分子量: 理論値: 523.18 Da

Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP / GTP, エネルギー貯蔵分子*YM

分子 #61: MAGNESIUM ION

• 分子: 名称: MAGNESIUM ION / タイプ: ligand / ID: 61 / コピー数: 1 / 式: MG
• 分子量: 理論値: 24.305 Da

実験情報

構造解析

• 手法: クライオ電子顕微鏡法
• 解析: 単粒子再構成法
• 試料の集合状態: particle

試料調製

• 緩衝液: pH: 7.5
• 凍結: 凍結剤: ETHANE

電子顕微鏡法

• 顕微鏡: FEI TITAN KRIOS
• 撮影: フィルム・検出器のモデル: GATAN K2 QUANTUM (4k x 4k); 平均電子線量: 1.8 e/Ų
• 電子線: 加速電圧: 300 kV / 電子線源: FIELD EMISSION GUN
• 電子光学系: 照射モード: OTHER / 撮影モード: DIFFRACTION / 最大 デフォーカス（公称値）: 1.8 µm / 最小 デフォーカス（公称値）: 1.2 µm
• 実験機器: モデル: Titan Krios / 画像提供: FEI Company

画像解析

• 初期モデル: モデルのタイプ: INSILICO MODEL
• 最終 再構成: 解像度のタイプ: BY AUTHOR / 解像度: 3.2 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 使用した粒子像数: 26584
• 初期 角度割当: タイプ: MAXIMUM LIKELIHOOD
• 最終 角度割当: タイプ: MAXIMUM LIKELIHOOD