登録情報 | データベース: EMDB / ID: EMD-27055 |
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タイトル | Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy |
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マップデータ | |
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試料 | - ウイルス:
![](img/tx_virus.gif) Zika virus (ジカ熱ウイルス)- タンパク質・ペプチド: C8 scFv heavy chain
- タンパク質・ペプチド: C8 scFv light chain
- タンパク質・ペプチド: Ankyrin repeat family A protein 2,Envelope E protein
- タンパク質・ペプチド: Membrane M protein
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キーワード | ZIKV / scFv antibody / VIRUS-IMMUNE SYSTEM complex |
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機能・相同性 | 機能・相同性情報
low-density lipoprotein particle receptor binding / regulation of protein-containing complex assembly / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / ribonucleoside triphosphate phosphatase activity / histone deacetylase binding / double-stranded RNA binding / viral capsid / regulation of gene expression / mRNA (nucleoside-2'-O-)-methyltransferase activity / mRNA 5'-cap (guanine-N7-)-methyltransferase activity ...low-density lipoprotein particle receptor binding / regulation of protein-containing complex assembly / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / ribonucleoside triphosphate phosphatase activity / histone deacetylase binding / double-stranded RNA binding / viral capsid / regulation of gene expression / mRNA (nucleoside-2'-O-)-methyltransferase activity / mRNA 5'-cap (guanine-N7-)-methyltransferase activity / RNA helicase activity / host cell endoplasmic reticulum membrane / cytoskeleton / protein dimerization activity / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / symbiont entry into host cell / viral RNA genome replication / serine-type endopeptidase activity / RNA-dependent RNA polymerase activity / virus-mediated perturbation of host defense response / fusion of virus membrane with host endosome membrane / ubiquitin protein ligase binding / host cell nucleus / virion attachment to host cell / protein kinase binding / virion membrane / structural molecule activity / protein-containing complex / proteolysis / extracellular region / ATP binding / membrane / nucleus / metal ion binding / cytosol類似検索 - 分子機能 : / Flavivirus capsid protein C superfamily / RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / Flavivirus non-structural protein NS2B / Flavivirus envelope glycoprotein E, stem/anchor domain / : / Flavivirus NS3 helicase, C-terminal helical domain / Genome polyprotein, Flavivirus / Flavivirus non-structural protein NS4A ...: / Flavivirus capsid protein C superfamily / RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / Flavivirus non-structural protein NS2B / Flavivirus envelope glycoprotein E, stem/anchor domain / : / Flavivirus NS3 helicase, C-terminal helical domain / Genome polyprotein, Flavivirus / Flavivirus non-structural protein NS4A / Flavivirus non-structural protein NS2B / Flavivirus capsid protein C / Flavivirus non-structural protein NS4B / mRNA cap 0/1 methyltransferase / Flavivirus capsid protein C / Flavivirus non-structural protein NS4B / Flavivirus non-structural protein NS4A / Flavivirus NS2B domain profile. / mRNA cap 0 and cap 1 methyltransferase (EC 2.1.1.56 and EC 2.1.1.57) domain profile. / Flavivirus non-structural protein NS2A / Flavivirus non-structural protein NS2A / Flavivirus NS3, petidase S7 / Peptidase S7, Flavivirus NS3 serine protease / Flavivirus NS3 protease (NS3pro) domain profile. / RNA-directed RNA polymerase, flavivirus / Flavivirus RNA-directed RNA polymerase, fingers and palm domains / Flavivirus non-structural Protein NS1 / Flavivirus non-structural protein NS1 / Envelope glycoprotein M, flavivirus / Flavivirus envelope glycoprotein M / Envelope glycoprotein M superfamily, flavivirus / Flavivirus polyprotein propeptide / Flavivirus polyprotein propeptide superfamily / Flavivirus polyprotein propeptide / Flaviviral glycoprotein E, central domain, subdomain 1 / Flaviviral glycoprotein E, central domain, subdomain 2 / Flavivirus envelope glycoprotein E, Stem/Anchor domain / Flavivirus glycoprotein E, immunoglobulin-like domain / Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily / Flavivirus glycoprotein, immunoglobulin-like domain / Flavivirus glycoprotein central and dimerisation domain / Flavivirus glycoprotein, central and dimerisation domains / Ribosomal RNA methyltransferase, FtsJ domain / FtsJ-like methyltransferase / Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily / Flavivirus glycoprotein, central and dimerisation domain superfamily / Flaviviral glycoprotein E, dimerisation domain / Ankyrin repeat / DEAD box, Flavivirus / Flavivirus DEAD domain / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / helicase superfamily c-terminal domain / Immunoglobulin E-set / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 Genome polyprotein / Genome polyprotein / Ankyrin repeat family A protein 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) / ![](img/tx_virus.gif) Zika virus (ジカ熱ウイルス) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.2 Å |
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データ登録者 | Liu W / Zhang XK / Gong DY / Dai XH / Sharma A / Zhang TH / Rey F / Zhou ZH |
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資金援助 | 米国, 3件 Organization | Grant number | 国 |
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National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR) | DE028583, DE025567 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | 1S10RR23057, 1S10OD018111, and 1U24GM116792 | 米国 | National Science Foundation (NSF, United States) | DBI-1338135 and DMR-1548924 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy 著者: Liu W / Zhang XK / Gong DY / Dai XH / Sharma A / Zhang TH / Rey F / Zhou ZH |
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履歴 | 登録 | 2022年5月21日 | - |
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ヘッダ(付随情報) 公開 | 2023年6月7日 | - |
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マップ公開 | 2023年6月7日 | - |
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更新 | 2023年6月7日 | - |
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現状 | 2023年6月7日 | 処理サイト: RCSB / 状態: 公開 |
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