登録情報 | データベース: EMDB / ID: EMD-22242 |
---|
タイトル | Full-length Hsc82 in complex with Aha1 in the presence of AMP-PNP |
---|
マップデータ | Hsc82 in complex with Aha1 in the presence of AMP-PNP |
---|
試料 | - 複合体: Full-length Hsc82 in complex with Aha1 in the presence of AMP-PNP
- タンパク質・ペプチド: ATP-dependent molecular chaperone HSC82
- タンパク質・ペプチド: Hsp90 co-chaperone AHA1
- リガンド: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
- リガンド: MAGNESIUM ION
- リガンド: POTASSIUM ION
|
---|
機能・相同性 | 機能・相同性情報
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / eNOS activation / Extra-nuclear estrogen signaling / VEGFR2 mediated vascular permeability / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / HSF1-dependent transactivation / HSF1 activation / response to oxygen levels / box C/D snoRNP assembly / ATPase activator activity ...Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / eNOS activation / Extra-nuclear estrogen signaling / VEGFR2 mediated vascular permeability / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / HSF1-dependent transactivation / HSF1 activation / response to oxygen levels / box C/D snoRNP assembly / ATPase activator activity / proteasome assembly / Neutrophil degranulation / telomere maintenance / ATP-dependent protein folding chaperone / protein import into nucleus / unfolded protein binding / protein folding / protein-folding chaperone binding / cellular response to heat / protein stabilization / perinuclear region of cytoplasm / ATP hydrolysis activity / protein-containing complex / mitochondrion / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Activator of Hsp90 ATPase, N-terminal / Activator of Hsp90 ATPase, Aha1 / Activator of Hsp90 ATPase, N-terminal / Activator of Hsp90 ATPase, N-terminal / Activator of Hsp90 ATPase homologue 1-like / Activator of Hsp90 ATPase homolog 1-like protein / START-like domain superfamily / Heat shock protein Hsp90, conserved site / Heat shock hsp90 proteins family signature. / HSP90, C-terminal domain ...Activator of Hsp90 ATPase, N-terminal / Activator of Hsp90 ATPase, Aha1 / Activator of Hsp90 ATPase, N-terminal / Activator of Hsp90 ATPase, N-terminal / Activator of Hsp90 ATPase homologue 1-like / Activator of Hsp90 ATPase homolog 1-like protein / START-like domain superfamily / Heat shock protein Hsp90, conserved site / Heat shock hsp90 proteins family signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPases / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily / Ribosomal protein S5 domain 2-type fold類似検索 - ドメイン・相同性 ATP-dependent molecular chaperone HSC82 / Hsp90 co-chaperone AHA1類似検索 - 構成要素 |
---|
生物種 | ![](img/tx_yeast.gif) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (パン酵母) |
---|
手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.15 Å |
---|
データ登録者 | Liu YX / Sun M / Myasnikov AG / Elnatan D / Agard DA |
---|
資金援助 | 米国, 5件 Organization | Grant number | 国 |
---|
Howard Hughes Medical Institute (HHMI) | | 米国 | American Heart Association | | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | U54CA209891 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | S10OD020054 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | S10OD021741 | 米国 |
|
---|
引用 | ジャーナル: To Be Published タイトル: Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1 著者: Liu YX / Sun M / Myasnikov AG / Elnatan D / Agard DA |
---|
履歴 | 登録 | 2020年6月28日 | - |
---|
ヘッダ(付随情報) 公開 | 2021年6月30日 | - |
---|
マップ公開 | 2021年6月30日 | - |
---|
更新 | 2021年6月30日 | - |
---|
現状 | 2021年6月30日 | 処理サイト: RCSB / 状態: 公開 |
---|
|
---|