登録情報 | データベース: EMDB / ID: EMD-16850 |
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タイトル | Cryo-EM structure of actomyosin-5a-S1 with the full-length lever (nucleotide free, class D) |
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マップデータ | DeepEMhancer post-processed map |
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試料 | - 複合体: Myosin-5a bound to F-actin
- 複合体: Actin, alpha skeletal muscle
- タンパク質・ペプチド: Actin, alpha skeletal muscle
- 複合体: Unconventional myosin-Va with calmodulin-1 bound
- タンパク質・ペプチド: Unconventional myosin-Va
- 複合体: Calmodulin-1
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キーワード | myosin / cytoskeletal motor / myosin-va / myo5a / myosin-5a / S1 / rigor / nucleotide free / apo / lever / 6IQ / actomyosin / actomyosin-5a / actin / actomyosin-va / actin bound / MOTOR PROTEIN |
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機能・相同性 | 機能・相同性情報
actomyosin, myosin complex part / establishment of endoplasmic reticulum localization to postsynapse / axo-dendritic protein transport / positive regulation of cellular response to insulin stimulus / melanosome localization / CaMK IV-mediated phosphorylation of CREB / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Glycogen breakdown (glycogenolysis) / Activation of RAC1 downstream of NMDARs ...actomyosin, myosin complex part / establishment of endoplasmic reticulum localization to postsynapse / axo-dendritic protein transport / positive regulation of cellular response to insulin stimulus / melanosome localization / CaMK IV-mediated phosphorylation of CREB / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Glycogen breakdown (glycogenolysis) / Activation of RAC1 downstream of NMDARs / Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / Activation of Ca-permeable Kainate Receptor / CLEC7A (Dectin-1) induces NFAT activation / endoplasmic reticulum localization / Synthesis of IP3 and IP4 in the cytosol / RHO GTPases activate PAKs / Calmodulin induced events / Inactivation, recovery and regulation of the phototransduction cascade / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / Calcineurin activates NFAT / eNOS activation / Ion transport by P-type ATPases / presynaptic endocytosis / Unblocking of NMDA receptors, glutamate binding and activation / locomotion involved in locomotory behavior / Protein methylation / RAF activation / reactive gliosis / melanin metabolic process / VEGFR2 mediated vascular permeability / RAS processing / Ca2+ pathway / unconventional myosin complex / FCERI mediated Ca+2 mobilization / Smooth Muscle Contraction / RHO GTPases activate IQGAPs / Extra-nuclear estrogen signaling / insulin-responsive compartment / RAF/MAP kinase cascade / melanosome transport / negative regulation of dopamine secretion / PKA activation / developmental pigmentation / regulation of postsynaptic cytosolic calcium ion concentration / secretory granule localization / actin filament-based movement / melanocyte differentiation / Regulation of actin dynamics for phagocytic cup formation / postsynaptic actin cytoskeleton / vesicle transport along actin filament / Platelet degranulation / melanin biosynthetic process / hair follicle maturation / regulation of exocytosis / Stimuli-sensing channels / actomyosin / Ion homeostasis / type 3 metabotropic glutamate receptor binding / negative regulation of synaptic transmission, glutamatergic / ATP-dependent protein binding / positive regulation of vascular associated smooth muscle cell migration / long-chain fatty acid biosynthetic process / insulin secretion / myosin complex / odontogenesis / syntaxin-1 binding / pigmentation / intermediate filament / organelle localization by membrane tethering / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / cytoskeletal motor activator activity / microfilament motor activity / regulation of cardiac muscle cell action potential / tropomyosin binding / myosin heavy chain binding / mesenchyme migration / nitric-oxide synthase binding / troponin I binding / dopamine metabolic process / negative regulation of ryanodine-sensitive calcium-release channel activity / adenylate cyclase activator activity / protein phosphatase activator activity / exocytosis / filamentous actin / actin filament bundle / skeletal muscle thin filament assembly / actin filament bundle assembly / calyx of Held / cytoskeletal motor activity / striated muscle thin filament / adenylate cyclase binding / skeletal muscle myofibril / catalytic complex / actin monomer binding / regulation of cardiac muscle contraction / detection of calcium ion / photoreceptor outer segment / regulation of ryanodine-sensitive calcium-release channel activity類似検索 - 分子機能 Myosin 5a, cargo-binding domain / Class V myosin, motor domain / Dilute domain / DIL domain / Dilute domain profile. / DIL / IQ calmodulin-binding motif / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. / Short calmodulin-binding motif containing conserved Ile and Gln residues. ...Myosin 5a, cargo-binding domain / Class V myosin, motor domain / Dilute domain / DIL domain / Dilute domain profile. / DIL / IQ calmodulin-binding motif / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. / Short calmodulin-binding motif containing conserved Ile and Gln residues. / Myosin head, motor domain / Myosin head (motor domain) / Myosin motor domain profile. / Myosin. Large ATPases. / IQ motif, EF-hand binding site / IQ motif profile. / : / Kinesin motor domain superfamily / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Actin / Actin family / Actin / EF-hand domain pair / EF-hand, calcium binding motif / ATPase, nucleotide binding domain / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 Calmodulin-1 / Actin, alpha skeletal muscle / Unconventional myosin-Va類似検索 - 構成要素 |
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生物種 | Oryctolagus cuniculus (ウサギ) / Mus musculus (ハツカネズミ) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 7.5 Å |
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データ登録者 | Gravett MSC / Klebl DP / Harlen OG / Read DJ / Harris SA / Muench SP / Peckham M |
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資金援助 | 英国, 5件 Organization | Grant number | 国 |
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Wellcome Trust | 102174/B/13/Z | 英国 | Wellcome Trust | 223125/Z/21/Z | 英国 | Wellcome Trust | 108466/Z/15/Z | 英国 | Engineering and Physical Sciences Research Council | EP/T022167/1 | 英国 | Engineering and Physical Sciences Research Council | EP/R013012 | 英国 |
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引用 | ジャーナル: To Be Published タイトル: Unveiling the Structural Dynamics of Myosin 5a: Cryo-EM Insights into the Motor Protein's Lever Conformations and Walking Mechanics 著者: Gravett MSC / Klebl DP / Harlen OG / Read DJ / Harris SA / Muench SP / Peckham M |
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履歴 | 登録 | 2023年3月14日 | - |
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ヘッダ(付随情報) 公開 | 2024年9月25日 | - |
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マップ公開 | 2024年9月25日 | - |
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更新 | 2024年9月25日 | - |
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現状 | 2024年9月25日 | 処理サイト: PDBe / 状態: 公開 |
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