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- SASDGE2: Human mitochondrial iron-sulfur cluster assembly ISCA2 protein -

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ID or keywords:

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Basic information

Entry
Database: SASBDB / ID: SASDGE2
SampleHuman mitochondrial iron-sulfur cluster assembly ISCA2 protein
  • Iron-sulfur cluster assembly 2 homolog, mitochondrial (protein), ISCA2, Homo sapiens
Function / homology
Function and homology information


protein maturation by [4Fe-4S] cluster transfer / Mitochondrial iron-sulfur cluster biogenesis / iron-sulfur cluster assembly / 2 iron, 2 sulfur cluster binding / 4 iron, 4 sulfur cluster binding / mitochondrial matrix / iron ion binding / mitochondrion
Similarity search - Function
FeS cluster insertion, C-terminal, conserved site / Hypothetical hesB/yadR/yfhF family signature. / FeS cluster insertion protein / FeS cluster biogenesis / HesB-like domain superfamily / Iron-sulphur cluster biosynthesis
Similarity search - Domain/homology
Iron-sulfur cluster assembly 2 homolog, mitochondrial
Similarity search - Component
Biological speciesHomo sapiens (human)
Contact author
  • Stefano Da Vela (EMBL-Hamburg, European Molecular Biology Laboratory (EMBL) - Hamburg outstation, Notkestraße 85, Geb. 25A, 22607 Hamburg, Deutschland, Germany)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #3572
Type: atomic / Radius of dummy atoms: 1.90 A / Chi-square value: 1.063
Search similar-shape structures of this assembly by Omokage search (details)
Model #3573
Type: atomic / Radius of dummy atoms: 1.90 A / Chi-square value: 1.136
Search similar-shape structures of this assembly by Omokage search (details)
Model #3574
Type: atomic / Radius of dummy atoms: 1.90 A / Chi-square value: 1.216
Search similar-shape structures of this assembly by Omokage search (details)
Model #3575
Type: atomic / Radius of dummy atoms: 1.90 A / Chi-square value: 1.049
Search similar-shape structures of this assembly by Omokage search (details)
Model #3576
Type: dummy / Radius of dummy atoms: 1.90 A
Comment: Monsa model (together with the complex, see entry SASDGF2)
Chi-square value: 0.961
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Human mitochondrial iron-sulfur cluster assembly ISCA2 protein
BufferName: 50 mM phosphate, 150 mM NaCl, 5 mM DTT / pH: 7
Entity #1802Name: ISCA2 / Type: protein
Description: Iron-sulfur cluster assembly 2 homolog, mitochondrial
Formula weight: 12.041 / Num. of mol.: 2 / Source: Homo sapiens / References: UniProt: Q86U28
Sequence:
EAGEGQIRLT DSCVQRLLEI TEGSEFLRLQ VEGGGCSGFQ YKFSLDTVIN PDDRVFEQGG ARVVVDSDSL AFVKGAQVDF SQELIRSSFQ VLNNPQAQQG CSCGSSFSIK L

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Experimental information

BeamInstrument name: PETRA III EMBL P12 / City: Hamburg / 国: Germany / Type of source: X-ray synchrotronSynchrotron / Wavelength: 0.124 Å / Dist. spec. to detc.: 3 mm
DetectorName: Pilatus 6M
Scan
Title: Human mitochondrial iron-sulfur cluster assembly ISCA2 protein
Measurement date: Sep 16, 2018 / Storage temperature: 20 °C / Cell temperature: 20 °C / Exposure time: 0.995 sec. / Number of frames: 2400 / Unit: 1/nm /
MinMax
Q0.1034 7.3052
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 1378 /
MinMax
Q0.133847 3.93923
P(R) point1 1378
R0 6.65
Result
Type of curve: sec /
ExperimentalPorod
MW18.7 kDa19 kDa
Volume-31 nm3

P(R)GuinierGuinier error
Forward scattering, I089.45 89 0.3
Radius of gyration, Rg2.07 nm2.03 nm0.049

MinMax
D-6.65
Guinier point12 195

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