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- SASDFM8: GON7, the fifth subunit of human KEOPS, bound to the EKC/KEOPS co... -
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Open data
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Basic information
Entry | ![]() |
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![]() | GON7, the fifth subunit of human KEOPS, bound to the EKC/KEOPS complex subunit, LAGE3
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Function / homology | ![]() tRNA threonylcarbamoyladenosine metabolic process / EKC/KEOPS complex / tRNA threonylcarbamoyladenosine modification / tRNA modification in the nucleus and cytosol / tRNA processing / nuclear body / nucleolus / nucleoplasm / nucleus / cytoplasm / cytosol Similarity search - Function |
Biological species | ![]() |
![]() | ![]() Title: Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome Authors: Arrondel C / Missoury S / Snoek R / Patat J / Menara G / Collinet B / Liger D / Durand D / Gribouval O / Boyer O / Buscara L / Martin G / Machuca E / Nevo F / Lescop E / Braun D / Boschat A ...Authors: Arrondel C / Missoury S / Snoek R / Patat J / Menara G / Collinet B / Liger D / Durand D / Gribouval O / Boyer O / Buscara L / Martin G / Machuca E / Nevo F / Lescop E / Braun D / Boschat A / Sanquer S / Guerrera I / Revy P / Parisot M / Masson C / Boddaert N / Charbit M / Decramer S / Novo R / Macher M / Ranchin B / Bacchetta J / Laurent A / Collardeau-Frachon S / van Eerde A / Hildebrandt F / Magen D / Antignac C / van Tilbeurgh H |
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Structure visualization
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Downloads & links
-Data source
SASBDB page | ![]() |
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-Related structure data
Related structure data | C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
-Models
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Sample
![]() | Name: GON7, the fifth subunit of human KEOPS, bound to the EKC/KEOPS complex subunit, LAGE3 Specimen concentration: 0.7 mg/ml / Entity id: 1764 / 1765 |
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Buffer | Name: 20 mM MES, 200 mM NaCl, 5 mM β-mercaptoethanol / pH: 6.5 |
Entity #1764 | Name: GON7 / Type: protein / Description: EKC/KEOPS complex subunit GON7 / Formula weight: 12.59 / Num. of mol.: 2 / Source: Homo sapiens / References: UniProt: Q9BXV9 Sequence: MGHHHHHHEN LYFQGELLGE YVGQEGKPQK LRVSCEAPGD GDPFQGLLSG VAQMKDMVTE LFDPLVQGEV QHRVAAAPDE DLDGDDEDDA EDENNIDNRT NFDGPSAKRP KTPS |
Entity #1765 | Name: LAGE3 / Type: protein / Description: EKC/KEOPS complex subunit LAGE3 / Formula weight: 16.478 / Num. of mol.: 2 / Source: Homo sapiens / References: UniProt: Q14657 Sequence: MHHHHHHENL YFQGRDADAD AGGGADGGDG RGGHSCRGGV DTAAAPAGGA PPAHAPGPGR DAASAARGSR MRPHIFTLSV PFPTPLEAEI AHGSLAPDAE PHQRVVGKDL TVSGRILVVR WKAEDCRLLR ISVINFLDQL SLVVRTMQRF GPPVSR |
-Experimental information
Beam | Instrument name: SOLEIL SWING ![]() ![]() | |||||||||||||||||||||||||||||||||
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Detector | Name: AVIEX PCCD170170 / Type: CCD | |||||||||||||||||||||||||||||||||
Scan | Measurement date: Mar 19, 2017 / Cell temperature: 15 °C / Exposure time: 1 sec. / Number of frames: 255 / Unit: 1/A /
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Distance distribution function P(R) |
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Result | Comments: The scattered intensities were displayed on an absolute scale (cm-1) using the scattering of water. SAXS data were normalized to the intensity of the incident beam, averaged and background ...Comments: The scattered intensities were displayed on an absolute scale (cm-1) using the scattering of water. SAXS data were normalized to the intensity of the incident beam, averaged and background subtracted using the program US-SOMO. Frames were examined individually and 36 frames were averaged and further processed. The corresponding SEC-elution concentration was approximately 0.7 mg/mL.
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