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基本情報
登録情報 | ![]() |
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![]() | Neural/ectodermal development factor IMP-L2 in complex with insulin-like peptide 5 (DILP5)
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機能・相同性 | ![]() positive regulation of entry into reproductive diapause / dendrite self-avoidance / cell-cell adhesion mediator activity / negative regulation of lipid storage / insulin binding / response to starvation / homophilic cell adhesion via plasma membrane adhesion molecules / positive regulation of insulin receptor signaling pathway / negative regulation of insulin receptor signaling pathway / axon guidance ...positive regulation of entry into reproductive diapause / dendrite self-avoidance / cell-cell adhesion mediator activity / negative regulation of lipid storage / insulin binding / response to starvation / homophilic cell adhesion via plasma membrane adhesion molecules / positive regulation of insulin receptor signaling pathway / negative regulation of insulin receptor signaling pathway / axon guidance / determination of adult lifespan / hormone activity / axon / extracellular space / extracellular region / plasma membrane 類似検索 - 分子機能 |
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![]() | ![]() タイトル: Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. 著者: Nikolaj Kulahin Roed / Cristina M Viola / Ole Kristensen / Gerd Schluckebier / Mathias Norrman / Waseem Sajid / John D Wade / Asser Sloth Andersen / Claus Kristensen / Timothy R Ganderton / ...著者: Nikolaj Kulahin Roed / Cristina M Viola / Ole Kristensen / Gerd Schluckebier / Mathias Norrman / Waseem Sajid / John D Wade / Asser Sloth Andersen / Claus Kristensen / Timothy R Ganderton / Johan P Turkenburg / Pierre De Meyts / Andrzej M Brzozowski / ![]() ![]() ![]() ![]() 要旨: The insulin/insulin-like growth factor signalling axis is an evolutionary ancient and highly conserved hormonal system involved in the regulation of metabolism, growth and lifespan in animals. Human ...The insulin/insulin-like growth factor signalling axis is an evolutionary ancient and highly conserved hormonal system involved in the regulation of metabolism, growth and lifespan in animals. Human insulin is stored in the pancreas, while insulin-like growth factor-1 (IGF-1) is maintained in blood in complexes with IGF-binding proteins (IGFBP1-6). Insect insulin-like polypeptide binding proteins (IBPs) have been considered as IGFBP-like structural and functional homologues. Here, we report structures of the Drosophila IBP Imp-L2 in its free form and bound to Drosophila insulin-like peptide 5 and human IGF-1. Imp-L2 contains two immunoglobulin-like fold domains and its architecture is unrelated to human IGFBPs, suggesting a distinct strategy for bioavailability regulation of insulin-like hormones. Similar hormone binding modes may exist in other insect vectors, as the IBP sequences are highly conserved. Therefore, these findings may open research routes towards a rational interference of transmission of diseases such as malaria, dengue and yellow fevers. |
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-関連構造データ
関連構造データ | ![]() 6feyC ![]() 6ff3C C: 同じ文献を引用 ( |
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類似構造データ | 類似検索 - 機能・相同性 ![]() |
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-モデル
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試料
![]() | 名称: Neural/ectodermal development factor IMP-L2 in complex with insulin-like peptide 5 (DILP5) 試料濃度: 2.30-9.30 / Entity id: 1135 / 1154 |
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バッファ | 名称: phosphate buffered saline / pH: 7.4 |
要素 #1135 | タイプ: protein / 記述: Insulin-like peptide 5 / 分子量: 5.385 / 分子数: 1 / 由来: Drosophila melanogaster / 参照: UniProt: E7BBS4 配列: NSLRACGPAL MDMLRVACPN GFNSMFAKGV VDSCCRKSCS FSTLRAYCDS |
要素 #1154 | 名称: Imp-L2 IBP / タイプ: protein / 記述: Neural/ectodermal development factor IMP-L2 / 分子量: 29.895 / 分子数: 1 / 由来: Drosophila melanogaster / 参照: UniProt: Q09024 配列: MEAKMNLHVC ALALLLFGSI ATVRGRAVDL VDDSNDVDNS IEAEEEKPRN RAFEADWLKF TKTPPTKLQQ ADGATIEIVC EMMGSQVPSI QWVVGHLPRS ELDDLDSNQV AEEAPSAIVR VRSSHIIDHV LSEARTYTCV GRTGSKTIYA STVVHPPRSS RLTPEKTYPG ...配列: MEAKMNLHVC ALALLLFGSI ATVRGRAVDL VDDSNDVDNS IEAEEEKPRN RAFEADWLKF TKTPPTKLQQ ADGATIEIVC EMMGSQVPSI QWVVGHLPRS ELDDLDSNQV AEEAPSAIVR VRSSHIIDHV LSEARTYTCV GRTGSKTIYA STVVHPPRSS RLTPEKTYPG AQKPRIIYTE KTHLDLMGSN IQLPCRVHAR PRAEITWLNN ENKEIVQGHR HRVLANGDLL ISEIKWEDMG NYKCIARNVV GKDTADTFVY PVLNEED |
-実験情報
ビーム | 設備名称: ESRF ID14-3 / 地域: Grenoble / 国: France ![]() | ||||||||||||||||||||||||||||||
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検出器 | 名称: Pilatus 1M / タイプ: Dectris / Pixsize x: 172 mm | ||||||||||||||||||||||||||||||
スキャン | 測定日: 2011年11月20日 / 保管温度: 5 °C / セル温度: 25 °C / 照射時間: 10 sec. / フレーム数: 10 / 単位: 1/nm /
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結果 | カーブのタイプ: merged /
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