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TitleStructures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
Journal, issue, pagesNat Commun, Vol. 9, Issue 1, Page 3860, Year 2018
Publish dateSep 21, 2018
AuthorsNikolaj Kulahin Roed / Cristina M Viola / Ole Kristensen / Gerd Schluckebier / Mathias Norrman / Waseem Sajid / John D Wade / Asser Sloth Andersen / Claus Kristensen / Timothy R Ganderton / Johan P Turkenburg / Pierre De Meyts / Andrzej M Brzozowski /
PubMed AbstractThe insulin/insulin-like growth factor signalling axis is an evolutionary ancient and highly conserved hormonal system involved in the regulation of metabolism, growth and lifespan in animals. Human ...The insulin/insulin-like growth factor signalling axis is an evolutionary ancient and highly conserved hormonal system involved in the regulation of metabolism, growth and lifespan in animals. Human insulin is stored in the pancreas, while insulin-like growth factor-1 (IGF-1) is maintained in blood in complexes with IGF-binding proteins (IGFBP1-6). Insect insulin-like polypeptide binding proteins (IBPs) have been considered as IGFBP-like structural and functional homologues. Here, we report structures of the Drosophila IBP Imp-L2 in its free form and bound to Drosophila insulin-like peptide 5 and human IGF-1. Imp-L2 contains two immunoglobulin-like fold domains and its architecture is unrelated to human IGFBPs, suggesting a distinct strategy for bioavailability regulation of insulin-like hormones. Similar hormone binding modes may exist in other insect vectors, as the IBP sequences are highly conserved. Therefore, these findings may open research routes towards a rational interference of transmission of diseases such as malaria, dengue and yellow fevers.
External linksNat Commun / PubMed:30242155 / PubMed Central
MethodsSAS (X-ray synchrotron) / X-ray diffraction
Resolution2.57 - 3.48 Å
Structure data

SASDDS8: Neural/ectodermal development factor IMP-L2 (Imp-L2 IBP)
Method: SAXS/SANS

SASDDT8: Neural/ectodermal development factor IMP-L2 in complex with insulin-like peptide 5 (DILP5)
Method: SAXS/SANS

PDB-6fey:
Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin
Method: X-RAY DIFFRACTION / Resolution: 3.48 Å

PDB-6ff3:
Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

Chemicals

ChemComp-HOH:
WATER / Water

Source
  • drosophila melanogaster (fruit fly)
  • homo sapiens (human)
KeywordsPEPTIDE BINDING PROTEIN / insulin / insulin binding protein / Drosophila / imaginal morphogenesis / IGF-I

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