[English] 日本語
![](img/lk-miru.gif)
- SASDDT8: Neural/ectodermal development factor IMP-L2 in complex with insul... -
+
Open data
-
Basic information
Entry | ![]() |
---|---|
![]() | Neural/ectodermal development factor IMP-L2 in complex with insulin-like peptide 5 (DILP5)
|
Function / homology | ![]() positive regulation of entry into reproductive diapause / dendrite self-avoidance / cell-cell adhesion mediator activity / negative regulation of lipid storage / insulin binding / response to starvation / homophilic cell adhesion via plasma membrane adhesion molecules / positive regulation of insulin receptor signaling pathway / negative regulation of insulin receptor signaling pathway / axon guidance ...positive regulation of entry into reproductive diapause / dendrite self-avoidance / cell-cell adhesion mediator activity / negative regulation of lipid storage / insulin binding / response to starvation / homophilic cell adhesion via plasma membrane adhesion molecules / positive regulation of insulin receptor signaling pathway / negative regulation of insulin receptor signaling pathway / axon guidance / determination of adult lifespan / hormone activity / axon / extracellular space / extracellular region / plasma membrane Similarity search - Function |
Biological species | ![]() ![]() |
![]() | ![]() Title: Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Authors: Nikolaj Kulahin Roed / Cristina M Viola / Ole Kristensen / Gerd Schluckebier / Mathias Norrman / Waseem Sajid / John D Wade / Asser Sloth Andersen / Claus Kristensen / Timothy R Ganderton / ...Authors: Nikolaj Kulahin Roed / Cristina M Viola / Ole Kristensen / Gerd Schluckebier / Mathias Norrman / Waseem Sajid / John D Wade / Asser Sloth Andersen / Claus Kristensen / Timothy R Ganderton / Johan P Turkenburg / Pierre De Meyts / Andrzej M Brzozowski / ![]() ![]() ![]() ![]() Abstract: The insulin/insulin-like growth factor signalling axis is an evolutionary ancient and highly conserved hormonal system involved in the regulation of metabolism, growth and lifespan in animals. Human ...The insulin/insulin-like growth factor signalling axis is an evolutionary ancient and highly conserved hormonal system involved in the regulation of metabolism, growth and lifespan in animals. Human insulin is stored in the pancreas, while insulin-like growth factor-1 (IGF-1) is maintained in blood in complexes with IGF-binding proteins (IGFBP1-6). Insect insulin-like polypeptide binding proteins (IBPs) have been considered as IGFBP-like structural and functional homologues. Here, we report structures of the Drosophila IBP Imp-L2 in its free form and bound to Drosophila insulin-like peptide 5 and human IGF-1. Imp-L2 contains two immunoglobulin-like fold domains and its architecture is unrelated to human IGFBPs, suggesting a distinct strategy for bioavailability regulation of insulin-like hormones. Similar hormone binding modes may exist in other insect vectors, as the IBP sequences are highly conserved. Therefore, these findings may open research routes towards a rational interference of transmission of diseases such as malaria, dengue and yellow fevers. |
![]() |
|
-
Structure visualization
-
Downloads & links
-Data source
SASBDB page | ![]() |
---|
-Related structure data
Related structure data | ![]() 6feyC ![]() 6ff3C C: citing same article ( |
---|---|
Similar structure data | Similarity search - Function & homology ![]() |
-
External links
Related items in Molecule of the Month |
---|
-Models
-
Sample
![]() | Name: Neural/ectodermal development factor IMP-L2 in complex with insulin-like peptide 5 (DILP5) Specimen concentration: 2.30-9.30 / Entity id: 1135 / 1154 |
---|---|
Buffer | Name: phosphate buffered saline / pH: 7.4 |
Entity #1135 | Type: protein / Description: Insulin-like peptide 5 / Formula weight: 5.385 / Num. of mol.: 1 / Source: Drosophila melanogaster / References: UniProt: E7BBS4 Sequence: NSLRACGPAL MDMLRVACPN GFNSMFAKGV VDSCCRKSCS FSTLRAYCDS |
Entity #1154 | Name: Imp-L2 IBP / Type: protein / Description: Neural/ectodermal development factor IMP-L2 / Formula weight: 29.895 / Num. of mol.: 1 / Source: Drosophila melanogaster / References: UniProt: Q09024 Sequence: MEAKMNLHVC ALALLLFGSI ATVRGRAVDL VDDSNDVDNS IEAEEEKPRN RAFEADWLKF TKTPPTKLQQ ADGATIEIVC EMMGSQVPSI QWVVGHLPRS ELDDLDSNQV AEEAPSAIVR VRSSHIIDHV LSEARTYTCV GRTGSKTIYA STVVHPPRSS RLTPEKTYPG ...Sequence: MEAKMNLHVC ALALLLFGSI ATVRGRAVDL VDDSNDVDNS IEAEEEKPRN RAFEADWLKF TKTPPTKLQQ ADGATIEIVC EMMGSQVPSI QWVVGHLPRS ELDDLDSNQV AEEAPSAIVR VRSSHIIDHV LSEARTYTCV GRTGSKTIYA STVVHPPRSS RLTPEKTYPG AQKPRIIYTE KTHLDLMGSN IQLPCRVHAR PRAEITWLNN ENKEIVQGHR HRVLANGDLL ISEIKWEDMG NYKCIARNVV GKDTADTFVY PVLNEED |
-Experimental information
Beam | Instrument name: ESRF ID14-3 / City: Grenoble / 国: France ![]() | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Detector | Name: Pilatus 1M / Type: Dectris / Pixsize x: 172 mm | ||||||||||||||||||||||||||||||
Scan | Measurement date: Nov 20, 2011 / Storage temperature: 5 °C / Cell temperature: 25 °C / Exposure time: 10 sec. / Number of frames: 10 / Unit: 1/nm /
| ||||||||||||||||||||||||||||||
Result | Type of curve: merged /
|