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- PDB-9xu3: Human minor spliceosome exon-ligation-ready C* complex (prior to ... -

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Open data

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Basic information

Entry

Database: PDB / ID: 9xu3

Title

Human minor spliceosome exon-ligation-ready C* complex (prior to step-II)

Components

(Peptidyl-prolyl cis-trans isomerase-like ...) x 2
(Pre-mRNA-splicing factor ...) x 5
(RNA-binding protein ...) x 3
(Small nuclear ribonucleoprotein ...) x 6
(Splicing factor ...) x 2
(U5 small nuclear ribonucleoprotein ...) x 2
(U6 snRNA-associated Sm-like protein ...) x 7
116 kDa U5 small nuclear ribonucleoprotein component
ATP-dependent RNA helicase DHX8
Armadillo repeat-containing protein 7
Cell division cycle 5-like protein
Coiled-coil domain-containing protein 12
Crooked neck-like protein 1
Eukaryotic initiation factor 4A-III
MSE-U12_5 exon
MSE-U12_intron-3 exon
NF-kappa-B-activating protein
Peptidyl-prolyl cis-trans isomerase E
Peptidylprolyl isomerase domain and WD repeat-containing protein 1
Pleiotropic regulator 1
Pre-mRNA-processing factor 19
Pre-mRNA-processing-splicing factor 8
Protein FAM204A
Protein FAM32A
Protein mago nashi homolog
RNA helicase aquarius
SNW domain-containing protein 1
Serine/arginine repetitive matrix protein 2
Small nuclear ribonucleoprotein-associated proteins B and B'
Spliceosome-associated protein CWC15 homolog
U12 snRNA
U5 snRNA
U6atac snRNA
WD repeat-containing protein 25

Keywords

SPLICING / minor spliceosome / U12-dependent spliceosome / U12-type splicing / step-II / exon ligation / snRNP / U12 / U5 / U6atac / intron lariat / splice site / exon

Function / homology

Function and homology information

U12 snRNA binding / second spliceosomal transesterification activity / exon-exon junction subcomplex mago-y14 / negative regulation of selenocysteine incorporation / cellular response to selenite ion / Lsm2-8 complex / U6 snRNA 3'-end binding / post-spliceosomal complex / exon-exon junction complex / regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ...U12 snRNA binding / second spliceosomal transesterification activity / exon-exon junction subcomplex mago-y14 / negative regulation of selenocysteine incorporation / cellular response to selenite ion / Lsm2-8 complex / U6 snRNA 3'-end binding / post-spliceosomal complex / exon-exon junction complex / regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / regulation of vitamin D receptor signaling pathway / pre-mRNA 3'-splice site binding / selenocysteine insertion sequence binding / mRNA decay by 5' to 3' exoribonuclease / Lsm1-7-Pat1 complex / mRNA metabolic process / regulation of translation at postsynapse, modulating synaptic transmission / U6 snRNP / regulation of retinoic acid receptor signaling pathway / PH domain binding / alternative mRNA splicing, via spliceosome / negative regulation of toll-like receptor signaling pathway / post-mRNA release spliceosomal complex / U2 snRNP binding / U7 snRNA binding / histone pre-mRNA DCP binding / generation of catalytic spliceosome for first transesterification step / U7 snRNP / 3'-5' RNA helicase activity / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / cis assembly of pre-catalytic spliceosome / histone pre-mRNA 3'end processing complex / deadenylation-dependent decapping of nuclear-transcribed mRNA / nuclear histone mRNA catabolic process / negative regulation of lipopolysaccharide-mediated signaling pathway / embryonic cranial skeleton morphogenesis / SLBP independent Processing of Histone Pre-mRNAs / regulation of mRNA processing / SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs / Deadenylation of mRNA / negative regulation of interleukin-8 production / negative regulation of interferon-beta production / negative regulation of excitatory postsynaptic potential / positive regulation of alpha-beta T cell differentiation / embryonic brain development / poly(A) binding / 7-methylguanosine cap hypermethylation / U12-type spliceosomal complex / positive regulation of mRNA splicing, via spliceosome / nuclear retinoic acid receptor binding / U1 snRNP binding / C2H2 zinc finger domain binding / pICln-Sm protein complex / U2-type catalytic step 1 spliceosome / methylosome / regulation of mRNA splicing, via spliceosome / ATP-dependent activity, acting on RNA / RNA splicing, via transesterification reactions / mRNA 3'-end processing / sno(s)RNA-containing ribonucleoprotein complex / small nuclear ribonucleoprotein complex / M-decay: degradation of maternal mRNAs by maternally stored factors / SMN-Sm protein complex / spliceosomal tri-snRNP complex / positive regulation of vitamin D receptor signaling pathway / commitment complex / P granule / U4 snRNP / snRNP binding / host-mediated activation of viral transcription / U2-type precatalytic spliceosome / mRNA cis splicing, via spliceosome / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / U2-type prespliceosome assembly / RUNX3 regulates NOTCH signaling / U2-type catalytic step 2 spliceosome / Notch binding / U2-type spliceosomal complex / nuclear vitamin D receptor binding / telomerase holoenzyme complex / Transport of Mature mRNA derived from an Intron-Containing Transcript / NOTCH4 Intracellular Domain Regulates Transcription / telomerase RNA binding / exploration behavior / positive regulation of neurogenesis / U1 snRNP / U2 snRNP / spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) / negative regulation of type I interferon-mediated signaling pathway / RNA Polymerase II Transcription Termination / P-body assembly / NOTCH3 Intracellular Domain Regulates Transcription / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / protein methylation / mRNA stabilization / U2-type prespliceosome / tRNA processing / protein peptidyl-prolyl isomerization / K63-linked polyubiquitin modification-dependent protein binding / nuclear androgen receptor binding
Similarity search - Function

Protein FAM204A / : / RBM48, RNA recognition motif / RNA-binding protein 48 / Armadillo repeat-containing protein 7 / RNA-binding region-containing protein RBM41/RNPC3 / : / RNA-binding protein 48 helical domain / NF-kappa-B-activating protein, C-terminal / NF-kappa-B-activating protein ...Protein FAM204A / : / RBM48, RNA recognition motif / RNA-binding protein 48 / Armadillo repeat-containing protein 7 / RNA-binding region-containing protein RBM41/RNPC3 / : / RNA-binding protein 48 helical domain / NF-kappa-B-activating protein, C-terminal / NF-kappa-B-activating protein / NF-kappa-B-activating protein C-terminal domain / NF-kappa-B-activating protein / Protein FAM32A / Cactin, central domain / Cactin, C-terminal / FAM32A / Cactus-binding C-terminus of cactin protein / Conserved mid region of cactin / Nuclear protein DGCR14/ESS-2 / Nuclear protein Es2 / mRNA splicing factor Cwf18-like / cwf18 pre-mRNA splicing factor / Pre-mRNA-splicing factor SLU7 domain / Pre-mRNA-splicing factor SLU7 / Pre-mRNA splicing Prp18-interacting factor / DHX8/ Prp22, DEXH-box helicase domain / Mago nashi protein / RNA-binding motif protein 8 / RBM8, RNA recognition motif / Mago nashi superfamily / : / : / Mago nashi protein / Pre-mRNA-splicing factor Isy1 / Pre-mRNA-splicing factor Isy1 superfamily / Isy1-like splicing family / : / Prp19 WD40 domain / : / : / Intron-binding protein aquarius, beta-barrel / Intron-binding protein aquarius insert domain / Peptidyl-prolyl cis-trans isomerase E / Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif / Sm-like protein Lsm8 / Pre-mRNA-splicing factor SPF27 / Breast carcinoma amplified sequence 2 (BCAS2) / U6 snRNA-associated Sm-like protein LSm2 / Sm-like protein Lsm4 / Sm-like protein Lsm7 / U6 snRNA-associated Sm-like protein Lsm1/8 / Sm-like protein LSm5 / Sm-like protein Lsm3 / U6 snRNA-associated Sm-like protein Lsm3 / CWF11 family / Intron-binding protein aquarius, N-terminal / Intron-binding protein aquarius N-terminal / Helix hairpin bin domain superfamily / Cactus-binding C-terminus of cactin protein / : / : / mRNA splicing factor Cwf21 domain / cwf21 domain / UPF1-type helicase core domain profile. / Pre-mRNA-splicing factor 19 / Pre-mRNA-processing factor 19 / : / Prp19/Pso4-like / : / Pre-mRNA-splicing factor SYF1 middle HAT repeat / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like / : / Pre-mRNA-splicing factor Syf1/CRNKL1 C-terminal HAT repeat / DNA2/NAM7 helicase, helicase domain / AAA domain / U-box domain / SKI-interacting protein SKIP, SNW domain / Pre-mRNA-splicing factor Cwf15/Cwc15 / SKI-interacting protein, SKIP / SKIP/SNW domain / Cwf15/Cwc15 cell cycle control protein / WD repeat Prp46/PLRG1-like / : / Initiation factor eIF-4 gamma, MA3 / Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal / : / : / : / MA3 domain / pre-mRNA splicing factor component / Pre-mRNA-splicing factor Syf1/CNRKL1 N-terminal HAT repeat / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. / DNA2/NAM7-like helicase / : / MIF4G domain / Small ribonucleoprotein associated, SmB/SmN / Myb-like DNA-binding domain / Middle domain of eukaryotic initiation factor 4G (eIF4G) / MIF4G-like, type 3
Similarity search - Domain/homology

ADENOSINE-5'-DIPHOSPHATE / ADENOSINE-5'-TRIPHOSPHATE / GUANOSINE-5'-TRIPHOSPHATE / INOSITOL HEXAKISPHOSPHATE / : / : / RNA / RNA (> 10) / RNA (> 100) / Pleiotropic regulator 1 ...ADENOSINE-5'-DIPHOSPHATE / ADENOSINE-5'-TRIPHOSPHATE / GUANOSINE-5'-TRIPHOSPHATE / INOSITOL HEXAKISPHOSPHATE / : / : / RNA / RNA (> 10) / RNA (> 100) / Pleiotropic regulator 1 / RNA helicase aquarius / U5 small nuclear ribonucleoprotein 200 kDa helicase / Pre-mRNA-splicing factor SPF27 / Pre-mRNA-splicing factor SLU7 / U6 snRNA-associated Sm-like protein LSm8 / Small nuclear ribonucleoprotein-associated proteins B and B' / Eukaryotic initiation factor 4A-III / Protein mago nashi homolog / Small nuclear ribonucleoprotein E / Small nuclear ribonucleoprotein F / Small nuclear ribonucleoprotein G / U6 snRNA-associated Sm-like protein LSm3 / U6 snRNA-associated Sm-like protein LSm6 / Small nuclear ribonucleoprotein Sm D1 / Small nuclear ribonucleoprotein Sm D2 / Small nuclear ribonucleoprotein Sm D3 / SNW domain-containing protein 1 / ATP-dependent RNA helicase DHX8 / 116 kDa U5 small nuclear ribonucleoprotein component / RNA-binding protein 48 / WD repeat-containing protein 25 / Pre-mRNA-processing-splicing factor 8 / NF-kappa-B-activating protein / Coiled-coil domain-containing protein 12 / Splicing factor Cactin / Peptidylprolyl isomerase domain and WD repeat-containing protein 1 / Splicing factor ESS-2 homolog / U5 small nuclear ribonucleoprotein 40 kDa protein / RNA-binding protein 41 / Cell division cycle 5-like protein / Crooked neck-like protein 1 / Peptidyl-prolyl cis-trans isomerase-like 3 / Armadillo repeat-containing protein 7 / Protein FAM204A / Pre-mRNA-splicing factor CWC22 homolog / Pre-mRNA-splicing factor SYF1 / Spliceosome-associated protein CWC15 homolog / U6 snRNA-associated Sm-like protein LSm7 / Pre-mRNA-splicing factor ISY1 homolog / Pre-mRNA-processing factor 19 / Peptidyl-prolyl cis-trans isomerase E / Serine/arginine repetitive matrix protein 2 / U6 snRNA-associated Sm-like protein LSm2 / Peptidyl-prolyl cis-trans isomerase-like 1 / Protein FAM32A / U6 snRNA-associated Sm-like protein LSm5 / U6 snRNA-associated Sm-like protein LSm4 / RNA-binding protein 8A
Similarity search - Component

Biological species

Homo sapiens (human)

Method

ELECTRON MICROSCOPY / single particle reconstruction / cryo EM / Resolution: 3 Å

Authors

Wan, R. / Bai, R.

Funding support

China, 1items

Citation

Journal: Vita / Year: 2026
Title: Molecular mechanism of the catalysis for U12-type splicing by the human
Authors: Bai, R. / Guo, H. / Sun, R. / Zhu, Y. / Shi, Y. / Wan, R.

History

Deposition	Nov 24, 2025	Deposition site: PDBJ / Processing site: PDBC
Revision 1.0	Aug 12, 2026	Provider: repository / Type: Initial release
Revision 1.0	Aug 12, 2026	Data content type: EM metadata / Data content type: EM metadata / Provider: repository / Type: Initial release

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Structure visualization

Structure viewer	Molecule: MolmilJmol/JSmol

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Downloads & links

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Download

PDBx/mmCIF format	9xu3.cif.gz	3.4 MB	Display	PDBx/mmCIF format
PDB format	pdb9xu3.ent.gz		Display	PDB format
PDBx/mmJSON format	9xu3.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/xu/9xu3 ftp://data.pdbj.org/pub/pdb/validation_reports/xu/9xu3	HTTPS FTP

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Related structure data

Related structure data	67263MC 67250C 81104C 81123C 81125C 81127C 81129C 81130C 81137C 81138C 81139C 81140C 81143C 81144C 81145C 81204C 9xttC M: map data used to model this data C: citing same article (ref.)
Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#121 - Jan 2010 70S Ribosomes similarity (16) #245 - May 2020 Spliceosomes similarity (90) #130 - Oct 2010 Riboswitches similarity (3) #16 - Apr 2001 Aminoacyl-tRNA Synthetases similarity (1) #157 - Jan 2013 Transfer-Messenger RNA similarity (7) #253 - Jan 2021 Expressome similarity (6) #260 - Aug 2021 Ribonuclease P similarity (2) #181 - Jan 2015 Cascade and CRISPR similarity (1) #229 - Jan 2019 Fluorescent RNA Aptamers similarity (1) #146 - Feb 2012 Aminoglycoside Antibiotics similarity (2) #15 - Mar 2001 Transfer RNA similarity (1) #249 - Sep 2020 SARS-CoV-2 RNA-dependent RNA Polymerase similarity (1) #10 - Oct 2000 Ribosome similarity (2) #210 - Jun 2017 Adenine Riboswitch in Action similarity (1) #87 - Mar 2007 Zinc Fingers similarity (1) #230 - Feb 2019 Initiation Factor eIF4E similarity (12) #226 - Oct 2018 Aminoglycoside Antibiotics and Resistance similarity (2) #65 - May 2005 Self-splicing RNA similarity (3) #262 - Oct 2021 Fifty Years of Open Access to PDB Structures similarity (2) #81 - Sep 2006 Elongation Factors similarity (15) #105 - Sep 2008 Ribonuclease A similarity (1) #98 - Feb 2008 Small Interfering RNA similarity (1) #104 - Aug 2008 Selenocysteine Synthase similarity (6) #161 - May 2013 Ricin similarity (2) #227 - Nov 2018 Telomerase similarity (2) #266 - Feb 2022 Oligosaccharyltransferase similarity (2) #106 - Oct 2008 Poly(A) Polymerase similarity (3) #143 - Nov 2011 Toll-like Receptors similarity (1) #89 - May 2007 Aconitase and Iron Regulatory Protein 1 similarity (1) #122 - Feb 2010 Enhanceosome similarity (5) #85 - Jan 2007 Importins similarity (3) #205 - Jan 2017 Nuclear Pore Complex similarity (2) #163 - Jul 2013 HIV Capsid similarity (8) #88 - Apr 2007 Clathrin similarity (3) #242 - Feb 2020 Coronavirus Proteases similarity (2) #241 - Jan 2020 Twenty Years of Molecules similarity (4) #110 - Feb 2009 Auxin and TIR1 Ubiquitin Ligase similarity (1) #225 - Sep 2018 Phytase similarity (1) #86 - Feb 2007 Exosomes similarity (2) #166 - Oct 2013 Proteasome similarity (6) #99 - Mar 2008 Cadherin similarity (3) #60 - Dec 2004 Ubiquitin similarity (2) #141 - Sep 2011 O-GlcNAc Transferase similarity (2) #218 - Feb 2018 EPSP Synthase and Weedkillers similarity (1) #107 - Nov 2008 Mechanosensitive Channels similarity (1) #255 - Mar 2021 Cisplatin and DNA similarity (3) #234 - Jun 2019 MDM2 and Cancer similarity (2) #148 - Apr 2012 Ras Protein similarity (1) #196 - Apr 2016 Lead Poisoning similarity (1) #239 - Nov 2019 Phospholipase A2 similarity (1)

PDB pages

PDBj /

wwPDB /

NCBI

Related items in Molecule of the Month

#121 - Jan 2010
70S Ribosomes
similarity (16)
#245 - May 2020
Spliceosomes
similarity (90)
#130 - Oct 2010
Riboswitches
similarity (3)
#16 - Apr 2001
Aminoacyl-tRNA Synthetases
similarity (1)
#157 - Jan 2013
Transfer-Messenger RNA
similarity (7)
#253 - Jan 2021
Expressome
similarity (6)
#260 - Aug 2021
Ribonuclease P
similarity (2)
#181 - Jan 2015
Cascade and CRISPR
similarity (1)
#229 - Jan 2019
Fluorescent RNA Aptamers
similarity (1)
#146 - Feb 2012
Aminoglycoside Antibiotics
similarity (2)
#15 - Mar 2001
Transfer RNA
similarity (1)
#249 - Sep 2020
SARS-CoV-2 RNA-dependent RNA Polymerase
similarity (1)
#10 - Oct 2000
Ribosome
similarity (2)
#210 - Jun 2017
Adenine Riboswitch in Action
similarity (1)
#87 - Mar 2007
Zinc Fingers
similarity (1)
#230 - Feb 2019
Initiation Factor eIF4E
similarity (12)
#226 - Oct 2018
Aminoglycoside Antibiotics and Resistance
similarity (2)
#65 - May 2005
Self-splicing RNA
similarity (3)
#262 - Oct 2021
Fifty Years of Open Access to PDB Structures
similarity (2)
#81 - Sep 2006
Elongation Factors
similarity (15)
#105 - Sep 2008
Ribonuclease A
similarity (1)
#98 - Feb 2008
Small Interfering RNA
similarity (1)
#104 - Aug 2008
Selenocysteine Synthase
similarity (6)
#161 - May 2013
Ricin
similarity (2)
#227 - Nov 2018
Telomerase
similarity (2)
#266 - Feb 2022
Oligosaccharyltransferase
similarity (2)
#106 - Oct 2008
Poly(A) Polymerase
similarity (3)
#143 - Nov 2011
Toll-like Receptors
similarity (1)
#89 - May 2007
Aconitase and Iron Regulatory Protein 1
similarity (1)
#122 - Feb 2010
Enhanceosome
similarity (5)
#85 - Jan 2007
Importins
similarity (3)
#205 - Jan 2017
Nuclear Pore Complex
similarity (2)
#163 - Jul 2013
HIV Capsid
similarity (8)
#88 - Apr 2007
Clathrin
similarity (3)
#242 - Feb 2020
Coronavirus Proteases
similarity (2)
#241 - Jan 2020
Twenty Years of Molecules
similarity (4)
#110 - Feb 2009
Auxin and TIR1 Ubiquitin Ligase
similarity (1)
#225 - Sep 2018
Phytase
similarity (1)
#86 - Feb 2007
Exosomes
similarity (2)
#166 - Oct 2013
Proteasome
similarity (6)
#99 - Mar 2008
Cadherin
similarity (3)
#60 - Dec 2004
Ubiquitin
similarity (2)
#141 - Sep 2011
O-GlcNAc Transferase
similarity (2)
#218 - Feb 2018
EPSP Synthase and Weedkillers
similarity (1)
#107 - Nov 2008
Mechanosensitive Channels
similarity (1)
#255 - Mar 2021
Cisplatin and DNA
similarity (3)
#234 - Jun 2019
MDM2 and Cancer
similarity (2)
#148 - Apr 2012
Ras Protein
similarity (1)
#196 - Apr 2016
Lead Poisoning
similarity (1)
#239 - Nov 2019
Phospholipase A2
similarity (1)

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Assembly

Deposited unit

0: MSE-U12_5 exon

1: MSE-U12_intron-3 exon

2: U12 snRNA

4: Peptidylprolyl isomerase domain and WD repeat-containing protein 1

5: U5 snRNA

6: U6atac snRNA

A: Pre-mRNA-processing-splicing factor 8

B: 116 kDa U5 small nuclear ribonucleoprotein component

C: U5 small nuclear ribonucleoprotein 200 kDa helicase

D: U5 small nuclear ribonucleoprotein 40 kDa protein

E: Cell division cycle 5-like protein

F: Pre-mRNA-splicing factor SYF1

G: Crooked neck-like protein 1

H: Coiled-coil domain-containing protein 12

I: Pre-mRNA-splicing factor ISY1 homolog

J: SNW domain-containing protein 1

K: Pleiotropic regulator 1

L: RNA-binding protein 48

L2: U6 snRNA-associated Sm-like protein LSm2

L3: U6 snRNA-associated Sm-like protein LSm3

L4: U6 snRNA-associated Sm-like protein LSm4

L5: U6 snRNA-associated Sm-like protein LSm5

L6: U6 snRNA-associated Sm-like protein LSm6

L7: U6 snRNA-associated Sm-like protein LSm7

L8: U6 snRNA-associated Sm-like protein LSm8

M: Armadillo repeat-containing protein 7

N: Spliceosome-associated protein CWC15 homolog

O: Peptidyl-prolyl cis-trans isomerase-like 1

P: Peptidyl-prolyl cis-trans isomerase E

Q: RNA helicase aquarius

R: Peptidyl-prolyl cis-trans isomerase-like 3

S: Pre-mRNA-splicing factor SLU7

T: ATP-dependent RNA helicase DHX8

U: Serine/arginine repetitive matrix protein 2

V: Pre-mRNA-splicing factor CWC22 homolog

W: WD repeat-containing protein 25

X: Splicing factor Cactin

Y: Protein FAM32A

Z: NF-kappa-B-activating protein

a: Small nuclear ribonucleoprotein-associated proteins B and B'

b: Small nuclear ribonucleoprotein Sm D1

c: Small nuclear ribonucleoprotein Sm D2

d: Small nuclear ribonucleoprotein Sm D3

e: Small nuclear ribonucleoprotein E

f: Small nuclear ribonucleoprotein F

g: Small nuclear ribonucleoprotein G

h: Small nuclear ribonucleoprotein-associated proteins B and B'

i: Small nuclear ribonucleoprotein Sm D1

j: Small nuclear ribonucleoprotein Sm D2

k: Small nuclear ribonucleoprotein Sm D3

l: Small nuclear ribonucleoprotein E

m: Small nuclear ribonucleoprotein F

n: Small nuclear ribonucleoprotein G

p: Splicing factor ESS-2 homolog

q: Pre-mRNA-processing factor 19

r: Pre-mRNA-processing factor 19

s: Pre-mRNA-processing factor 19

t: Pre-mRNA-processing factor 19

u: Pre-mRNA-splicing factor SPF27

v: Eukaryotic initiation factor 4A-III

w: Protein mago nashi homolog

x: RNA-binding protein 8A

y: RNA-binding protein 41

z: Protein FAM204A

hetero molecules

3.32 MDa, 64 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Idetical with deposited unit
defined by author
Evidence: electron microscopy, not applicable

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Components

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RNA chain , 5 types, 5 molecules 01256

#1: RNA chain	MSE-U12_5 exon Mass: 18256.914 Da / Num. of mol.: 1 / Source method: obtained synthetically / Source: (synth.) Homo sapiens (human)
#2: RNA chain	MSE-U12_intron-3 exon Mass: 88640.148 Da / Num. of mol.: 1 / Source method: obtained synthetically / Source: (synth.) Homo sapiens (human)
#3: RNA chain	U12 snRNA Mass: 48353.625 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human)
#5: RNA chain	U5 snRNA Mass: 37254.855 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: GenBank: 20330981
#6: RNA chain	U6atac snRNA Mass: 40395.820 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human)

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Protein , 22 types, 26 molecules 4ABEGHJKMNPQTUWYZahqrstvwz

#4: Protein	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 / Spliceosome-associated cyclophilin Mass: 73679.891 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q96BP3, peptidylprolyl isomerase
#7: Protein	Pre-mRNA-processing-splicing factor 8 / 220 kDa U5 snRNP-specific protein / PRP8 homolog / Splicing factor Prp8 / p220 Mass: 273974.250 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q6P2Q9
#8: Protein	116 kDa U5 small nuclear ribonucleoprotein component / Elongation factor Tu GTP-binding domain-containing protein 2 / SNU114 homolog / hSNU114 / U5 snRNP- ...Elongation factor Tu GTP-binding domain-containing protein 2 / SNU114 homolog / hSNU114 / U5 snRNP-specific protein / 116 kDa / U5-116 kDa Mass: 109560.625 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q15029
#11: Protein	Cell division cycle 5-like protein / Cdc5-like protein / Pombe cdc5-related protein Mass: 92406.883 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q99459
#13: Protein	Crooked neck-like protein 1 / Crooked neck homolog / hCrn Mass: 100610.008 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BZJ0
#14: Protein	Coiled-coil domain-containing protein 12 Mass: 19223.850 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q8WUD4
#16: Protein	SNW domain-containing protein 1 / Nuclear protein SkiP / Nuclear receptor coactivator NCoA-62 / Ski-interacting protein Mass: 61770.648 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q13573
#17: Protein	Pleiotropic regulator 1 Mass: 57280.758 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: O43660
#26: Protein	Armadillo repeat-containing protein 7 Mass: 21946.039 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9H6L4
#27: Protein	Spliceosome-associated protein CWC15 homolog Mass: 26674.447 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9P013
#29: Protein	Peptidyl-prolyl cis-trans isomerase E / PPIase E / Cyclophilin E / Cyclophilin-33 / Rotamase E Mass: 33475.773 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9UNP9, peptidylprolyl isomerase
#30: Protein	RNA helicase aquarius / Intron-binding protein of 160 kDa / IBP160 Mass: 171502.453 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: O60306, RNA helicase
#33: Protein	ATP-dependent RNA helicase DHX8 / DEAH box protein 8 / RNA helicase HRH1 Mass: 139522.312 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q14562, RNA helicase
#34: Protein	Serine/arginine repetitive matrix protein 2 / 300 kDa nuclear matrix antigen / Serine/arginine-rich splicing factor-related nuclear matrix ...300 kDa nuclear matrix antigen / Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa / SR-related nuclear matrix protein of 300 kDa / Ser/Arg-related nuclear matrix protein of 300 kDa / Splicing coactivator subunit SRm300 / Tax-responsive enhancer element-binding protein 803 / TaxREB803 Mass: 300255.312 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9UQ35
#36: Protein	WD repeat-containing protein 25 Mass: 60245.027 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q64LD2
#38: Protein	Protein FAM32A / Ovarian tumor-associated gene 12 / OTAG-12 Mass: 13213.453 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y421
#39: Protein	NF-kappa-B-activating protein Mass: 47252.660 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q8N5F7
#40: Protein	Small nuclear ribonucleoprotein-associated proteins B and B' / snRNP-B / Sm protein B/B' / Sm-B/B' / SmB/B' Mass: 24642.131 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P14678
#48: Protein	Pre-mRNA-processing factor 19 / Nuclear matrix protein 200 / PRP19/PSO4 homolog / hPso4 / RING-type E3 ubiquitin transferase PRP19 ...Nuclear matrix protein 200 / PRP19/PSO4 homolog / hPso4 / RING-type E3 ubiquitin transferase PRP19 / Senescence evasion factor Mass: 55245.547 Da / Num. of mol.: 4 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) References: UniProt: Q9UMS4, RING-type E3 ubiquitin transferase
#50: Protein	Eukaryotic initiation factor 4A-III / eIF-4A-III / eIF4A-III / ATP-dependent RNA helicase DDX48 / ATP-dependent RNA helicase eIF4A-3 / ...eIF-4A-III / eIF4A-III / ATP-dependent RNA helicase DDX48 / ATP-dependent RNA helicase eIF4A-3 / DEAD box protein 48 / Eukaryotic initiation factor 4A-like NUK-34 / Eukaryotic translation initiation factor 4A isoform 3 / Nuclear matrix protein 265 / NMP 265 / hNMP 265 Mass: 46930.961 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P38919, RNA helicase
#51: Protein	Protein mago nashi homolog Mass: 17189.625 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61326
#54: Protein	Protein FAM204A Mass: 27070.291 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9H8W3

+
U5 small nuclear ribonucleoprotein ... , 2 types, 2 molecules CD

#9: Protein	U5 small nuclear ribonucleoprotein 200 kDa helicase / Activating signal cointegrator 1 complex subunit 3-like 1 / BRR2 homolog / U5 snRNP-specific 200 ...Activating signal cointegrator 1 complex subunit 3-like 1 / BRR2 homolog / U5 snRNP-specific 200 kDa protein / U5-200KD Mass: 244823.422 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: O75643, RNA helicase
#10: Protein	U5 small nuclear ribonucleoprotein 40 kDa protein / U5 snRNP 40 kDa protein / U5-40K / 38 kDa-splicing factor / Prp8-binding protein / hPRP8BP / U5 ...U5 snRNP 40 kDa protein / U5-40K / 38 kDa-splicing factor / Prp8-binding protein / hPRP8BP / U5 snRNP-specific 40 kDa protein / WD repeat-containing protein 57 Mass: 39359.492 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q96DI7

#9: Protein

U5 small nuclear ribonucleoprotein 200 kDa helicase / Activating signal cointegrator 1 complex subunit 3-like 1 / BRR2 homolog / U5 snRNP-specific 200 ...

Mass: 244823.422 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural)

Homo sapiens (human) / References: UniProt: O75643, RNA helicase

#10: Protein

U5 small nuclear ribonucleoprotein 40 kDa protein / U5 snRNP 40 kDa protein / U5-40K / 38 kDa-splicing factor / Prp8-binding protein / hPRP8BP / U5 ...

Mass: 39359.492 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural)

Homo sapiens (human) / References: UniProt: Q96DI7

+
Pre-mRNA-splicing factor ... , 5 types, 5 molecules FISVu

#12: Protein	Pre-mRNA-splicing factor SYF1 / Protein HCNP / XPA-binding protein 2 Mass: 100148.711 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9HCS7
#15: Protein	Pre-mRNA-splicing factor ISY1 homolog Mass: 33046.254 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9ULR0
#32: Protein	Pre-mRNA-splicing factor SLU7 / hSlu7 Mass: 68510.844 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: O95391
#35: Protein	Pre-mRNA-splicing factor CWC22 homolog / Nucampholin homolog / fSAPb Mass: 105646.578 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9HCG8
#49: Protein	Pre-mRNA-splicing factor SPF27 / Breast carcinoma-amplified sequence 2 / DNA amplified in mammary carcinoma 1 protein / Spliceosome- ...Breast carcinoma-amplified sequence 2 / DNA amplified in mammary carcinoma 1 protein / Spliceosome-associated protein SPF 27 Mass: 26163.420 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: O75934

+
RNA-binding protein ... , 3 types, 3 molecules Lxy

#18: Protein	RNA-binding protein 48 Mass: 41878.523 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q5RL73
#52: Protein	RNA-binding protein 8A / Binder of OVCA1-1 / BOV-1 / RNA-binding motif protein 8A / RNA-binding protein Y14 / Ribonucleoprotein RBM8A Mass: 19925.070 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y5S9
#53: Protein	RNA-binding protein 41 / RNA-binding motif protein 41 Mass: 47169.781 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q96IZ5

+
U6 snRNA-associated Sm-like protein ... , 7 types, 7 molecules L2L3L4L5L6L7L8

#19: Protein	U6 snRNA-associated Sm-like protein LSm2 / Protein G7b / Small nuclear ribonuclear protein D homolog / snRNP core Sm-like protein Sm-x5 Mass: 10847.495 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y333
#20: Protein	U6 snRNA-associated Sm-like protein LSm3 Mass: 11859.390 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62310
#21: Protein	U6 snRNA-associated Sm-like protein LSm4 / Glycine-rich protein / GRP Mass: 15375.775 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y4Z0
#22: Protein	U6 snRNA-associated Sm-like protein LSm5 Mass: 9945.448 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y4Y9
#23: Protein	U6 snRNA-associated Sm-like protein LSm6 Mass: 9139.571 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62312
#24: Protein	U6 snRNA-associated Sm-like protein LSm7 Mass: 11617.363 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9UK45
#25: Protein	U6 snRNA-associated Sm-like protein LSm8 Mass: 10410.589 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: O95777

+
Peptidyl-prolyl cis-trans isomerase-like ... , 2 types, 2 molecules OR

#28: Protein	Peptidyl-prolyl cis-trans isomerase-like 1 / PPIase / Rotamase PPIL1 Mass: 18257.805 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y3C6, peptidylprolyl isomerase
#31: Protein	Peptidyl-prolyl cis-trans isomerase-like 3 / PPIase / Cyclophilin J / CyPJ / Cyclophilin-like protein PPIL3 / Rotamase PPIL3 Mass: 18177.547 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9H2H8, peptidylprolyl isomerase

+
Splicing factor ... , 2 types, 2 molecules Xp

#37: Protein	Splicing factor Cactin / Renal carcinoma antigen NY-REN-24 Mass: 88860.062 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q8WUQ7
#47: Protein	Splicing factor ESS-2 homolog / DiGeorge syndrome critical region 13 / DiGeorge syndrome critical region 14 / DiGeorge syndrome ...DiGeorge syndrome critical region 13 / DiGeorge syndrome critical region 14 / DiGeorge syndrome protein H / DGS-H / Protein ES2 Mass: 52639.953 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q96DF8

#37: Protein

Splicing factor Cactin / Renal carcinoma antigen NY-REN-24

Mass: 88860.062 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural)

Homo sapiens (human) / References: UniProt: Q8WUQ7

#47: Protein

Splicing factor ESS-2 homolog / DiGeorge syndrome critical region 13 / DiGeorge syndrome critical region 14 / DiGeorge syndrome ...

Mass: 52639.953 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural)

Homo sapiens (human) / References: UniProt: Q96DF8

+
Small nuclear ribonucleoprotein ... , 6 types, 12 molecules bicjdkelfmgn

#41: Protein	Small nuclear ribonucleoprotein Sm D1 / Sm-D1 / Sm-D autoantigen / snRNP core protein D1 Mass: 13310.653 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62314
#42: Protein	Small nuclear ribonucleoprotein Sm D2 / Sm-D2 / snRNP core protein D2 Mass: 13551.928 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62316
#43: Protein	Small nuclear ribonucleoprotein Sm D3 / Sm-D3 / snRNP core protein D3 Mass: 13940.308 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62318
#44: Protein	Small nuclear ribonucleoprotein E / snRNP-E / Sm protein E / Sm-E / SmE Mass: 10817.601 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62304
#45: Protein	Small nuclear ribonucleoprotein F / snRNP-F / Sm protein F / Sm-F / SmF Mass: 9734.171 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62306
#46: Protein	Small nuclear ribonucleoprotein G / snRNP-G / Sm protein G / Sm-G / SmG Mass: 8508.084 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62308

+
Non-polymers , 8 types, 18 molecules

#55: Chemical	ChemComp-MG / MAGNESIUM ION Mass: 24.305 Da / Num. of mol.: 9 / Source method: obtained synthetically / Formula: Mg / Feature type: SUBJECT OF INVESTIGATION
#56: Chemical	ChemComp-K / POTASSIUM ION Mass: 39.098 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: K / Feature type: SUBJECT OF INVESTIGATION
#57: Chemical	ChemComp-IHP / INOSITOL HEXAKISPHOSPHATE / MYO-INOSITOL HEXAKISPHOSPHATE / INOSITOL 1,2,3,4,5,6-HEXAKISPHOSPHATE Mass: 660.035 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Formula: C₆H₁₈O₂₄P₆ / Feature type: SUBJECT OF INVESTIGATION
#58: Chemical	ChemComp-GTP / GUANOSINE-5'-TRIPHOSPHATE Mass: 523.180 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₁₀H₁₆N₅O₁₄P₃ / Feature type: SUBJECT OF INVESTIGATION / Comment: GTP, energy-carrying molecule*YM
#59: Chemical	ChemComp-ADP / ADENOSINE-5'-DIPHOSPHATE Mass: 427.201 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₁₀H₁₅N₅O₁₀P₂ / Feature type: SUBJECT OF INVESTIGATION / Comment: ADP, energy-carrying molecule*YM
#60: Chemical	ChemComp-ZN / ZINC ION Mass: 65.409 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: Zn / Feature type: SUBJECT OF INVESTIGATION
#61: Chemical	ChemComp-ATP / ADENOSINE-5'-TRIPHOSPHATE Mass: 507.181 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₁₀H₁₆N₅O₁₃P₃ / Feature type: SUBJECT OF INVESTIGATION / Comment: ATP, energy-carrying molecule*YM
#62: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Formula: H₂O

+
Details

Has ligand of interest	Y
Has protein modification	Y

-
Experimental details

-
Experiment

Experiment	Method: ELECTRON MICROSCOPY
EM experiment	Aggregation state: PARTICLE / 3D reconstruction method: single particle reconstruction

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Sample preparation

Component	Name: Human minor spliceosome exon-ligation-ready C* complex (prior to step-II) Type: COMPLEX / Entity ID: #1-#54 / Source: NATURAL
Source (natural)	Organism: Homo sapiens (human)
Buffer solution	pH: 7.9
Specimen	Embedding applied: NO / Shadowing applied: NO / Staining applied: NO / Vitrification applied: YES
Vitrification	Cryogen name: NITROGEN

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Electron microscopy imaging

Experimental equipment	Model: Titan Krios / Image courtesy: FEI Company
Microscopy	Model: TFS KRIOS
Electron gun	Electron source: FIELD EMISSION GUN / Accelerating voltage: 300 kV / Illumination mode: FLOOD BEAM
Electron lens	Mode: BRIGHT FIELD / Nominal defocus max: 1900 nm / Nominal defocus min: 1300 nm
Image recording	Electron dose: 50 e/Å² / Film or detector model: GATAN K3 (6k x 4k)

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Processing

EM software

ID	Name	Category
1	cryoSPARC	particle selection
2	PHENIX	model refinement
13	cryoSPARC	3D reconstruction

CTF correction

Type: PHASE FLIPPING AND AMPLITUDE CORRECTION

3D reconstruction

Resolution: 3 Å / Resolution method: FSC 0.143 CUT-OFF / Num. of particles: 145908 / Symmetry type: POINT

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RNA chain , 5 types, 5 molecules 01256

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Protein , 22 types, 26 molecules 4ABEGHJKMNPQTUWYZahqrstvwz

+
U5 small nuclear ribonucleoprotein ... , 2 types, 2 molecules CD

+
Pre-mRNA-splicing factor ... , 5 types, 5 molecules FISVu

+
RNA-binding protein ... , 3 types, 3 molecules Lxy

+
U6 snRNA-associated Sm-like protein ... , 7 types, 7 molecules L2L3L4L5L6L7L8

+
Peptidyl-prolyl cis-trans isomerase-like ... , 2 types, 2 molecules OR

+
Splicing factor ... , 2 types, 2 molecules Xp

+
Small nuclear ribonucleoprotein ... , 6 types, 12 molecules bicjdkelfmgn

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Non-polymers , 8 types, 18 molecules

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Details

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Experimental details

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Experiment

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Sample preparation

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+RNA chain , 5 types, 5 molecules 01256

+Protein , 22 types, 26 molecules 4ABEGHJKMNPQTUWYZahqrstvwz

+U5 small nuclear ribonucleoprotein ... , 2 types, 2 molecules CD

+Pre-mRNA-splicing factor ... , 5 types, 5 molecules FISVu

+RNA-binding protein ... , 3 types, 3 molecules Lxy

+U6 snRNA-associated Sm-like protein ... , 7 types, 7 molecules L2L3L4L5L6L7L8

+Peptidyl-prolyl cis-trans isomerase-like ... , 2 types, 2 molecules OR

+Splicing factor ... , 2 types, 2 molecules Xp

+Small nuclear ribonucleoprotein ... , 6 types, 12 molecules bicjdkelfmgn

+Non-polymers , 8 types, 18 molecules

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-Experimental details

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RNA chain , 5 types, 5 molecules 01256

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Protein , 22 types, 26 molecules 4ABEGHJKMNPQTUWYZahqrstvwz

+
U5 small nuclear ribonucleoprotein ... , 2 types, 2 molecules CD

+
Pre-mRNA-splicing factor ... , 5 types, 5 molecules FISVu

+
RNA-binding protein ... , 3 types, 3 molecules Lxy

+
U6 snRNA-associated Sm-like protein ... , 7 types, 7 molecules L2L3L4L5L6L7L8

+
Peptidyl-prolyl cis-trans isomerase-like ... , 2 types, 2 molecules OR

+
Splicing factor ... , 2 types, 2 molecules Xp

+
Small nuclear ribonucleoprotein ... , 6 types, 12 molecules bicjdkelfmgn

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Non-polymers , 8 types, 18 molecules

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Details

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Experimental details

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Experiment

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Sample preparation

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