登録情報 データベース : PDB / ID : 8q7n 構造の表示 ダウンロードとリンクタイトル cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) 要素(U4/U6 small nuclear ribonucleoprotein ...) x 3 116 kDa U5 small nuclear ribonucleoprotein component MINX pre-mRNA Microfibrillar-associated protein 1 NHP2-like protein 1, N-terminally processed Pre-mRNA-processing factor 6 Pre-mRNA-processing-splicing factor 8 Pre-mRNA-splicing factor 38A Protein BUD31 homolog Splicing factor 3A subunit 1 Thioredoxin-like protein 4A Transcription elongation regulator 1 U4 snRNA U4/U6.U5 tri-snRNP-associated protein 1 U5 snRNA U6 snRNA Ubiquitin-like protein 5 WW domain-binding protein 4 Zinc finger matrin-type protein 2 残り15件を表示 表示を減らす 詳細キーワード SPLICING / spliceosome (スプライセオソーム) / pre-catalytic spliceosome / spliceosomal B complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
microfibril / spliceosomal snRNP complex / ribonucleoprotein complex localization / U4atac snRNP / positive regulation of cytotoxic T cell differentiation / maturation of 5S rRNA / RNA localization / positive regulation of primary miRNA processing / U4atac snRNA binding / box C/D sno(s)RNA binding ... microfibril / spliceosomal snRNP complex / ribonucleoprotein complex localization / U4atac snRNP / positive regulation of cytotoxic T cell differentiation / maturation of 5S rRNA / RNA localization / positive regulation of primary miRNA processing / U4atac snRNA binding / box C/D sno(s)RNA binding / snRNP binding / 核小体 / transcription elongation factor activity / U4/U6 snRNP / positive regulation of androgen receptor activity / U2-type catalytic step 1 spliceosome / RNA splicing, via transesterification reactions / spliceosomal tri-snRNP complex / U4 snRNA binding / box C/D methylation guide snoRNP complex / mRNA cis splicing, via spliceosome / U2-type spliceosomal complex / U2-type precatalytic spliceosome / proline-rich region binding / U2-type prespliceosome assembly / U2-type catalytic step 2 spliceosome / ubiquitin-like protein conjugating enzyme binding / RNA polymerase binding / U4 snRNP / rRNA modification in the nucleus and cytosol / box C/D snoRNP assembly / U2 snRNP / positive regulation of protein targeting to mitochondrion / U3 snoRNA binding / U2-type prespliceosome / K63-linked polyubiquitin modification-dependent protein binding / positive regulation of miRNA metabolic process / precatalytic spliceosome / spliceosomal complex assembly / regulation of alternative mRNA splicing, via spliceosome / mRNA Splicing - Minor Pathway / negative regulation of transcription elongation by RNA polymerase II / mRNA 3'-splice site recognition / MLL1 complex / spliceosomal tri-snRNP complex assembly / single fertilization / Major pathway of rRNA processing in the nucleolus and cytosol / U5 snRNA binding / U5 snRNP / 転写後修飾 / U2 snRNA binding / カハール体 / U6 snRNA binding / spliceosomal snRNP assembly / ribonucleoprotein complex binding / pre-mRNA intronic binding / U1 snRNA binding / U4/U6 x U5 tri-snRNP complex / catalytic step 2 spliceosome / maturation of LSU-rRNA / mRNA Splicing - Major Pathway / RNA splicing / nuclear receptor coactivator activity / maturation of SSU-rRNA / response to cocaine / small-subunit processome / nuclear receptor binding / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / spliceosomal complex / protein modification process / 転写後修飾 / mRNA splicing, via spliceosome / protein tag activity / ribosomal small subunit biogenesis / transcription corepressor activity / cellular response to xenobiotic stimulus / protein-macromolecule adaptor activity / cellular response to tumor necrosis factor / ATPase binding / cellular response to lipopolysaccharide / RNA polymerase II-specific DNA-binding transcription factor binding / cytosolic large ribosomal subunit / transcription coactivator activity / nuclear speck / 細胞周期 / 細胞分裂 / intracellular membrane-bounded organelle / GTPase activity / 中心体 / クロマチン / 核小体 / GTP binding / ゴルジ体 / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / RNA binding / zinc ion binding 類似検索 - 分子機能 WW domain-binding protein 4 / Ubiquitin-like modifier Hub1/Ubl5 / Pre-mRNA-splicing factor 38, C-terminal / Pre-mRNA-splicing factor 38-associated hydrophilic C-term / Micro-fibrillar-associated protein 1, C-terminal / Microfibrillar-associated protein 1 / Microfibril-associated/Pre-mRNA processing / U4/U6.U5 small nuclear ribonucleoprotein component Snu23 / Pre-mRNA-splicing factor 38 / Transcription elongation regulator 1-like ... WW domain-binding protein 4 / Ubiquitin-like modifier Hub1/Ubl5 / Pre-mRNA-splicing factor 38, C-terminal / Pre-mRNA-splicing factor 38-associated hydrophilic C-term / Micro-fibrillar-associated protein 1, C-terminal / Microfibrillar-associated protein 1 / Microfibril-associated/Pre-mRNA processing / U4/U6.U5 small nuclear ribonucleoprotein component Snu23 / Pre-mRNA-splicing factor 38 / Transcription elongation regulator 1-like / PRP38 family / U1-C, C2H2-type zinc finger / U1 zinc finger / PRP4-like superfamily / pre-mRNA processing factor 4 (PRP4) like / FF domain / SNU66/SART1 family / HIND motif / SART-1 family / HIND motif / FF domain / PWI domain superfamily / FF domain superfamily / PWI domain / PWI domain profile. / FF domain profile. / Contains two conserved F residues / Pre-mRNA processing factor 4 (PRP4)-like / Splicing factor 3A subunit 1, ubiquitin domain / Splicing Factor Motif, present in Prp18 and Pr04 / Pre-mRNA-splicing factor 3 / U4/U6 small nuclear ribonucleoprotein Prp3 / pre-mRNA processing factor 3 domain / Prp31 C-terminal / U4/U6 small nuclear ribonucleoprotein Prp31 / Prp31 C terminal domain / Small nuclear ribonucleoprotein Prp3, C-terminal domain / Small nuclear ribonucleoprotein Prp3, C-terminal domain / PWI domain / PWI, domain in splicing factors / BUD31/G10-related, conserved site / G10 protein signature 1. / G10 protein signature 2. / Dim1 family / Mitosis protein DIM1 / Mitosis protein DIM1 / PRP1 splicing factor, N-terminal / PRP1 splicing factor, N-terminal / Splicing factor 3A subunit 1 / Splicing factor 3A subunit 1, conserved domain / Pre-mRNA splicing factor PRP21 like protein / G10 protein / Pre-mRNA-splicing factor BUD31 / SWAP/Surp / SWAP/Surp superfamily / Surp module / SURP motif repeat profile. / Suppressor-of-White-APricot splicing regulator / Matrin/U1-C, C2H2-type zinc finger / Zinc finger matrin-type profile. / Zinc-finger double-stranded RNA-binding / Zinc finger, double-stranded RNA binding / H/ACA ribonucleoprotein complex, subunit Nhp2-like / Pre-mRNA-splicing factor Syf1-like / NOSIC / NOSIC (NUC001) domain / Nop domain / Nop domain superfamily / Nop, C-terminal domain / snoRNA binding domain, fibrillarin / Nop domain profile. / Snu114, GTP-binding domain / Tetratricopeptide repeat / 116kDa U5 small nuclear ribonucleoprotein component, N-terminal / 116kDa U5 small nuclear ribonucleoprotein component, C-terminal / 116 kDa U5 small nuclear ribonucleoprotein component N-terminus / Matrin/U1-C-like, C2H2-type zinc finger / U1-like zinc finger / HAT (Half-A-TPR) repeat / HAT (Half-A-TPR) repeats / Tetratricopeptide repeat / Elongation Factor G, domain II / Elongation Factor G, domain III / JAB1/Mov34/MPN/PAD-1 ubiquitin protease / Translation elongation factor EFG/EF2, domain IV / Elongation factor G, domain IV / Elongation factor G, domain IV / Elongation factor G C-terminus / WWドメイン / Elongation factor EFG, domain V-like / Elongation factor G C-terminus / WW/rsp5/WWP domain signature. / EF-G domain III/V-like / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WWドメイン / PROCT domain / Prp8 RNase domain IV, fingers region / PROCT (NUC072) domain 類似検索 - ドメイン・相同性 : / : / リボ核酸 / RNA (> 10) / RNA (> 100) / Transcription elongation regulator 1 / U4/U6 small nuclear ribonucleoprotein Prp4 / U4/U6.U5 tri-snRNP-associated protein 1 / U4/U6 small nuclear ribonucleoprotein Prp3 / WW domain-binding protein 4 ... : / : / リボ核酸 / RNA (> 10) / RNA (> 100) / Transcription elongation regulator 1 / U4/U6 small nuclear ribonucleoprotein Prp4 / U4/U6.U5 tri-snRNP-associated protein 1 / U4/U6 small nuclear ribonucleoprotein Prp3 / WW domain-binding protein 4 / Pre-mRNA-processing factor 6 / Protein BUD31 homolog / Microfibrillar-associated protein 1 / NHP2-like protein 1 / Thioredoxin-like protein 4A / 116 kDa U5 small nuclear ribonucleoprotein component / Splicing factor 3A subunit 1 / Pre-mRNA-processing-splicing factor 8 / Pre-mRNA-splicing factor 38A / U4/U6 small nuclear ribonucleoprotein Prp31 / Zinc finger matrin-type protein 2 / Ubiquitin-like protein 5 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 3.1 Å 詳細データ登録者 Zhang, Z. / Kumar, V. / Dybkov, O. / Will, C.L. / Urlaub, H. / Stark, H. / Luehrmann, R. 資金援助 ドイツ, 1件 詳細 詳細を隠す組織 認可番号 国 German Research Foundation (DFG) ドイツ
引用ジャーナル : To Be Published タイトル : New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes著者 : Zhang, Z. / Kumar, V. / Dybkov, O. / Will, C.L. / Urlaub, H. / Stark, H. / Luehrmann, R. 履歴 登録 2023年8月16日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2024年1月24日 Provider : repository / タイプ : Initial release