登録情報 | データベース: PDB / ID: 8gdr |
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タイトル | SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21B10 |
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要素 | - Monoclonal antibody 002-S21B10 heavy chain variable domain
- Monoclonal antibody 002-S21B10 light chain variable domain
- Spike glycoprotein
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キーワード | VIRAL PROTEIN / antibody / spike / SARS-CoV-2 / viral protein-immune system complex |
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機能・相同性 | 機能・相同性情報
Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / symbiont-mediated-mediated suppression of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell ...Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / symbiont-mediated-mediated suppression of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell / membrane fusion / Attachment and Entry / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / host cell surface receptor binding / symbiont-mediated suppression of host innate immune response / receptor ligand activity / endocytosis involved in viral entry into host cell / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal / Spike glycoprotein, betacoronavirus / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus ...Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal / Spike glycoprotein, betacoronavirus / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2類似検索 - ドメイン・相同性 |
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生物種 |  Severe acute respiratory syndrome coronavirus 2 (ウイルス)
Homo sapiens (ヒト) |
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手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.6 Å |
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データ登録者 | Patel, A. / Ortlund, E.A. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | 5U19 AI14237-04 (subaward 000520244-SP008-SC014) | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Elucidating the mechanism of SARS-CoV-2 Omicron variant escape from a RBD class-3 human antibody 著者: Patel, A. / Kumar, S. / Lai, L. / Chakravarthy, C. / Valanparambil, R. / Keen, M. / Laughlin, Z.T. / Frank, F. / Cheedarla, N. / Verkerke, H.P. / Neish, A.S. / Roback, J.D. / Davis, C.W. / ...著者: Patel, A. / Kumar, S. / Lai, L. / Chakravarthy, C. / Valanparambil, R. / Keen, M. / Laughlin, Z.T. / Frank, F. / Cheedarla, N. / Verkerke, H.P. / Neish, A.S. / Roback, J.D. / Davis, C.W. / Wrammert, J. / Ahmed, R. / Suthar, M.S. / Murali-Krishna, K. / Chandele, A. / Ortlund, E.A. |
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履歴 | 登録 | 2023年3月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2024年3月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年10月23日 | Group: Data collection / Structure summary カテゴリ: em_admin / pdbx_entry_details / pdbx_modification_feature Item: _em_admin.last_update / _pdbx_entry_details.has_protein_modification |
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