登録情報 | データベース: PDB / ID: 7xf5 |
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タイトル | Full length human CLC-2 channel in apo state |
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要素 | Chloride channel protein 2 |
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キーワード | MEMBRANE PROTEIN / homo-dimer |
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機能・相同性 | 機能・相同性情報
regulation of aldosterone biosynthetic process / cell differentiation involved in salivary gland development / regulation of membrane depolarization during action potential / volume-sensitive chloride channel activity / astrocyte end-foot / stabilization of membrane potential / acinar cell differentiation / cellular hypotonic response / regulation of resting membrane potential / voltage-gated chloride channel activity ...regulation of aldosterone biosynthetic process / cell differentiation involved in salivary gland development / regulation of membrane depolarization during action potential / volume-sensitive chloride channel activity / astrocyte end-foot / stabilization of membrane potential / acinar cell differentiation / cellular hypotonic response / regulation of resting membrane potential / voltage-gated chloride channel activity / axon initial segment / chloride channel regulator activity / dendritic spine membrane / chloride transport / phagocytosis, engulfment / positive regulation of oligodendrocyte differentiation / chloride channel complex / lung development / Stimuli-sensing channels / myelin sheath / retina development in camera-type eye / perikaryon / basolateral plasma membrane / postsynaptic membrane / plasma membrane類似検索 - 分子機能 Chloride channel ClC-2 / : / Chloride channel, voltage gated / Chloride channel, core / Voltage gated chloride channel / CBS domain superfamily / CBS domain profile.類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.9 Å |
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データ登録者 | Wang, L. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | | 中国 |
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引用 | ジャーナル: Nat Commun / 年: 2023 タイトル: Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42 著者: Ma, T. / Wang, L. / Chai, A. / Liu, C. / Cui, W. / Yuan, S. / Wing Ngor Au, S. / Sun, L. / Zhang, X. / Zhang, Z. / Lu, J. / Gao, Y. / Wang, P. / Li, Z. / Liang, Y. / Vogel, H. / Wang, Y.T. / ...著者: Ma, T. / Wang, L. / Chai, A. / Liu, C. / Cui, W. / Yuan, S. / Wing Ngor Au, S. / Sun, L. / Zhang, X. / Zhang, Z. / Lu, J. / Gao, Y. / Wang, P. / Li, Z. / Liang, Y. / Vogel, H. / Wang, Y.T. / Wang, D. / Yan, K. / Zhang, H. |
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履歴 | 登録 | 2022年4月1日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2023年5月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月15日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.pdbx_database_id_DOI / _citation.title / _citation.year |
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