- PDB-7pkr: Vault structure in primmed conformation -
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基本情報
登録情報
データベース: PDB / ID: 7pkr
タイトル
Vault structure in primmed conformation
要素
Major vault protein
キーワード
STRUCTURAL PROTEIN / Transport
機能・相同性
機能・相同性情報
protein activation cascade / negative regulation of protein autophosphorylation / ERBB signaling pathway / Neutrophil degranulation / negative regulation of epidermal growth factor receptor signaling pathway / protein phosphatase binding / cell population proliferation / cytoskeleton / ribonucleoprotein complex / protein kinase binding ...protein activation cascade / negative regulation of protein autophosphorylation / ERBB signaling pathway / Neutrophil degranulation / negative regulation of epidermal growth factor receptor signaling pathway / protein phosphatase binding / cell population proliferation / cytoskeleton / ribonucleoprotein complex / protein kinase binding / perinuclear region of cytoplasm / identical protein binding / nucleus / cytoplasm 類似検索 - 分子機能
Major vault protein, N-terminal / Major vault protein, shoulder domain / Major vault protein / Major vault protein repeat domain 3 / Major vault protein repeat domain 2 / Major vault protein repeat domain 4 / Major vault protein repeat domain / Major vault protein repeat domain superfamily / Major vault protein repeat domain 2 superfamily / Major Vault Protein repeat domain ...Major vault protein, N-terminal / Major vault protein, shoulder domain / Major vault protein / Major vault protein repeat domain 3 / Major vault protein repeat domain 2 / Major vault protein repeat domain 4 / Major vault protein repeat domain / Major vault protein repeat domain superfamily / Major vault protein repeat domain 2 superfamily / Major Vault Protein repeat domain / Shoulder domain / Major Vault Protein repeat domain / Major Vault Protein Repeat domain / Major Vault Protein repeat domain / MVP (vault) repeat profile. / Band 7/SPFH domain superfamily 類似検索 - ドメイン・相同性
Spanish Ministry of Science, Innovation, and Universities
BIO2017-83906-P
スペイン
引用
ジャーナル: Sci Adv / 年: 2022 タイトル: Symmetry disruption commits vault particles to disassembly. 著者: Pablo Guerra / María González-Alamos / Aida Llauró / Arnau Casañas / Jordi Querol-Audí / Pedro J de Pablo / Núria Verdaguer / 要旨: Vaults are ubiquitous ribonucleoprotein particles involved in a diversity of cellular processes, with promising applications as nanodevices for delivery of multiple cargos. The vault shell is ...Vaults are ubiquitous ribonucleoprotein particles involved in a diversity of cellular processes, with promising applications as nanodevices for delivery of multiple cargos. The vault shell is assembled by the symmetrical association of multiple copies of the major vault protein that, initially, generates half vaults. The pairwise, anti-parallel association of two half vaults produces whole vaults. Here, using a combination of vault recombinant reconstitution and structural techniques, we characterized the molecular determinants for the vault opening process. This process commences with a relaxation of the vault waist, causing the expansion of the inner cavity. Then, local disengagement of amino-terminal domains at the vault midsection seeds a conformational change that leads to the aperture, facilitating access to the inner cavity where cargo is hosted. These results inform a hitherto uncharacterized step of the vault cycle and will aid current engineering efforts leveraging vault for tailored cargo delivery.
A: Major vault protein B: Major vault protein C: Major vault protein D: Major vault protein E: Major vault protein F: Major vault protein G: Major vault protein H: Major vault protein I: Major vault protein J: Major vault protein K: Major vault protein L: Major vault protein M: Major vault protein N: Major vault protein O: Major vault protein P: Major vault protein Q: Major vault protein R: Major vault protein S: Major vault protein T: Major vault protein V: Major vault protein W: Major vault protein X: Major vault protein Y: Major vault protein Z: Major vault protein AA: Major vault protein BA: Major vault protein CA: Major vault protein DA: Major vault protein EA: Major vault protein FA: Major vault protein GA: Major vault protein HA: Major vault protein IA: Major vault protein JA: Major vault protein KA: Major vault protein LA: Major vault protein MA: Major vault protein NA: Major vault protein OA: Major vault protein PA: Major vault protein QA: Major vault protein RA: Major vault protein SA: Major vault protein TA: Major vault protein UA: Major vault protein VA: Major vault protein WA: Major vault protein XA: Major vault protein YA: Major vault protein ZA: Major vault protein AB: Major vault protein BB: Major vault protein CB: Major vault protein DB: Major vault protein EB: Major vault protein FB: Major vault protein GB: Major vault protein HB: Major vault protein IB: Major vault protein JB: Major vault protein KB: Major vault protein LB: Major vault protein MB: Major vault protein NB: Major vault protein OB: Major vault protein PB: Major vault protein QB: Major vault protein RB: Major vault protein SB: Major vault protein TB: Major vault protein UB: Major vault protein VB: Major vault protein WB: Major vault protein XB: Major vault protein YB: Major vault protein ZB: Major vault protein AC: Major vault protein