protein activation cascade / ERBB signaling pathway / Neutrophil degranulation / negative regulation of epidermal growth factor receptor signaling pathway / protein phosphatase binding / cytoskeleton / cell population proliferation / ribonucleoprotein complex / protein kinase binding / perinuclear region of cytoplasm ...protein activation cascade / ERBB signaling pathway / Neutrophil degranulation / negative regulation of epidermal growth factor receptor signaling pathway / protein phosphatase binding / cytoskeleton / cell population proliferation / ribonucleoprotein complex / protein kinase binding / perinuclear region of cytoplasm / identical protein binding / nucleus / cytoplasm 類似検索 - 分子機能
Major vault protein, N-terminal / Major vault protein, shoulder domain / Major vault protein / Major vault protein repeat domain 3 / Major vault protein repeat domain 2 / Major vault protein repeat domain 4 / Major vault protein repeat domain / Major vault protein repeat domain superfamily / Major vault protein repeat domain 2 superfamily / Major Vault Protein repeat domain ...Major vault protein, N-terminal / Major vault protein, shoulder domain / Major vault protein / Major vault protein repeat domain 3 / Major vault protein repeat domain 2 / Major vault protein repeat domain 4 / Major vault protein repeat domain / Major vault protein repeat domain superfamily / Major vault protein repeat domain 2 superfamily / Major Vault Protein repeat domain / Shoulder domain / Major Vault Protein repeat domain / Major Vault Protein Repeat domain / Major Vault Protein repeat domain / MVP (vault) repeat profile. / Band 7/SPFH domain superfamily 類似検索 - ドメイン・相同性
ジャーナル: Science / 年: 2009 タイトル: The structure of rat liver vault at 3.5 angstrom resolution. 著者: Hideaki Tanaka / Koji Kato / Eiki Yamashita / Tomoyuki Sumizawa / Yong Zhou / Min Yao / Kenji Iwasaki / Masato Yoshimura / Tomitake Tsukihara / 要旨: Vaults are among the largest cytoplasmic ribonucleoprotein particles and are found in numerous eukaryotic species. Roles in multidrug resistance and innate immunity have been suggested, but the ...Vaults are among the largest cytoplasmic ribonucleoprotein particles and are found in numerous eukaryotic species. Roles in multidrug resistance and innate immunity have been suggested, but the cellular function remains unclear. We have determined the x-ray structure of rat liver vault at 3.5 angstrom resolution and show that the cage structure consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains. Each MVP monomer folds into 12 domains: nine structural repeat domains, a shoulder domain, a cap-helix domain, and a cap-ring domain. Interactions between the 42-turn-long cap-helix domains are key to stabilizing the particle. The shoulder domain is structurally similar to a core domain of stomatin, a lipid-raft component in erythrocytes and epithelial cells.
A: Major vault protein B: Major vault protein C: Major vault protein D: Major vault protein E: Major vault protein F: Major vault protein G: Major vault protein H: Major vault protein I: Major vault protein J: Major vault protein K: Major vault protein L: Major vault protein M: Major vault protein N: Major vault protein O: Major vault protein P: Major vault protein Q: Major vault protein R: Major vault protein S: Major vault protein T: Major vault protein U: Major vault protein V: Major vault protein W: Major vault protein X: Major vault protein Y: Major vault protein Z: Major vault protein a: Major vault protein b: Major vault protein c: Major vault protein d: Major vault protein e: Major vault protein f: Major vault protein g: Major vault protein h: Major vault protein i: Major vault protein j: Major vault protein k: Major vault protein l: Major vault protein m: Major vault protein
A: Major vault protein B: Major vault protein C: Major vault protein D: Major vault protein E: Major vault protein F: Major vault protein G: Major vault protein H: Major vault protein I: Major vault protein J: Major vault protein K: Major vault protein L: Major vault protein M: Major vault protein N: Major vault protein O: Major vault protein P: Major vault protein Q: Major vault protein R: Major vault protein S: Major vault protein T: Major vault protein U: Major vault protein V: Major vault protein W: Major vault protein X: Major vault protein Y: Major vault protein Z: Major vault protein a: Major vault protein b: Major vault protein c: Major vault protein d: Major vault protein e: Major vault protein f: Major vault protein g: Major vault protein h: Major vault protein i: Major vault protein j: Major vault protein k: Major vault protein l: Major vault protein m: Major vault protein
A: Major vault protein B: Major vault protein C: Major vault protein D: Major vault protein E: Major vault protein F: Major vault protein G: Major vault protein H: Major vault protein I: Major vault protein J: Major vault protein K: Major vault protein L: Major vault protein M: Major vault protein N: Major vault protein O: Major vault protein P: Major vault protein Q: Major vault protein R: Major vault protein S: Major vault protein T: Major vault protein U: Major vault protein V: Major vault protein W: Major vault protein X: Major vault protein Y: Major vault protein Z: Major vault protein a: Major vault protein b: Major vault protein c: Major vault protein d: Major vault protein e: Major vault protein f: Major vault protein g: Major vault protein h: Major vault protein i: Major vault protein j: Major vault protein k: Major vault protein l: Major vault protein m: Major vault protein