ジャーナル: Nat Microbiol / 年: 2020 タイトル: Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation. 著者: Steven Johnson / Yu Hang Fong / Justin C Deme / Emily J Furlong / Lucas Kuhlen / Susan M Lea / 要旨: The bacterial flagellum is a complex self-assembling nanomachine that confers motility to the cell. Despite great variation across species, all flagella are ultimately constructed from a helical ...The bacterial flagellum is a complex self-assembling nanomachine that confers motility to the cell. Despite great variation across species, all flagella are ultimately constructed from a helical propeller that is attached to a motor embedded in the inner membrane. The motor consists of a series of stator units surrounding a central rotor made up of two ring complexes, the MS-ring and the C-ring. Despite many studies, high-resolution structural information is still lacking for the MS-ring of the rotor, and proposed mismatches in stoichiometry between the two rings have long provided a source of confusion for the field. Here, we present structures of the Salmonella MS-ring, revealing a high level of variation in inter- and intrachain symmetry that provides a structural explanation for the ability of the MS-ring to function as a complex and elegant interface between the two main functions of the flagellum-protein secretion and rotation.
#262 - 2021年10月 PDB構造への50年間のオープンアクセス (Fifty Years of Open Access to PDB Structures ) 類似性 (7)
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A: Flagellar M-ring protein B: Flagellar M-ring protein C: Flagellar M-ring protein D: Flagellar M-ring protein E: Flagellar M-ring protein F: Flagellar M-ring protein G: Flagellar M-ring protein H: Flagellar M-ring protein I: Flagellar M-ring protein J: Flagellar M-ring protein K: Flagellar M-ring protein L: Flagellar M-ring protein M: Flagellar M-ring protein N: Flagellar M-ring protein O: Flagellar M-ring protein P: Flagellar M-ring protein Q: Flagellar M-ring protein R: Flagellar M-ring protein S: Flagellar M-ring protein T: Flagellar M-ring protein U: Flagellar M-ring protein V: Flagellar M-ring protein W: Flagellar M-ring protein X: Flagellar M-ring protein Y: Flagellar M-ring protein Z: Flagellar M-ring protein 1: Flagellar M-ring protein 2: Flagellar M-ring protein 3: Flagellar M-ring protein 4: Flagellar M-ring protein 5: Flagellar M-ring protein 6: Flagellar M-ring protein