登録情報 データベース : PDB / ID : 6kn8 構造の表示 ダウンロードとリンクタイトル Structure of human cardiac thin filament in the calcium bound state 要素(Tropomyosin alpha-1 ...) x 2 Actin, alpha skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, cardiac muscle Troponin T, cardiac muscle 詳細キーワード CONTRACTILE PROTEIN/ACTIN BINDING PROTEIN / Troponin / Tropomyosin / Actin / Thin filement / Muscle / CONTRACTILE PROTEIN-ACTIN BINDING PROTEIN complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of heart rate by epinephrine / muscle thin filament tropomyosin / regulation of systemic arterial blood pressure by ischemic conditions / troponin C binding / regulation of muscle filament sliding speed / troponin T binding / diaphragm contraction / regulation of ATP-dependent activity / cardiac Troponin complex / cardiac myofibril ... positive regulation of heart rate by epinephrine / muscle thin filament tropomyosin / regulation of systemic arterial blood pressure by ischemic conditions / troponin C binding / regulation of muscle filament sliding speed / troponin T binding / diaphragm contraction / regulation of ATP-dependent activity / cardiac Troponin complex / cardiac myofibril / troponin complex / bleb / negative regulation of vascular associated smooth muscle cell migration / regulation of smooth muscle contraction / regulation of muscle contraction / muscle filament sliding / transition between fast and slow fiber / negative regulation of ATP-dependent activity / ruffle organization / negative regulation of vascular associated smooth muscle cell proliferation / positive regulation of ATP-dependent activity / Striated Muscle Contraction / regulation of cardiac muscle contraction by calcium ion signaling / response to metal ion / structural constituent of muscle / ventricular cardiac muscle tissue morphogenesis / cytoskeletal motor activator activity / regulation of heart contraction / sarcomere organization / tropomyosin binding / heart contraction / mesenchyme migration / troponin I binding / myosin heavy chain binding / filamentous actin / actin filament bundle / skeletal muscle thin filament assembly / striated muscle thin filament / actin filament bundle assembly / skeletal muscle contraction / skeletal muscle myofibril / positive regulation of cell adhesion / actin monomer binding / Smooth Muscle Contraction / vasculogenesis / calcium channel inhibitor activity / skeletal muscle fiber development / cardiac muscle contraction / stress fiber / Ion homeostasis / titin binding / positive regulation of stress fiber assembly / cytoskeleton organization / cytoskeletal protein binding / actin filament polymerization / sarcomere / negative regulation of cell migration / filopodium / actin filament organization / actin filament / ruffle membrane / 加水分解酵素; 酸無水物に作用; 酸無水物に作用・細胞または細胞小器官の運動に関与 / wound healing / cellular response to reactive oxygen species / response to calcium ion / structural constituent of cytoskeleton / actin filament binding / intracellular calcium ion homeostasis / calcium-dependent protein binding / actin cytoskeleton / lamellipodium / heart development / actin binding / regulation of cell shape / cell body / cytoskeleton / hydrolase activity / protein domain specific binding / protein heterodimerization activity / calcium ion binding / positive regulation of gene expression / protein kinase binding / magnesium ion binding / protein homodimerization activity / ATP binding / identical protein binding / cytoplasm / cytosol 類似検索 - 分子機能 Troponin T / Troponin I residues 1-32 / Troponin I residues 1-32 / : / Tropomyosins signature. / Troponin / Troponin domain superfamily / Troponin / Tropomyosin / Tropomyosin ... Troponin T / Troponin I residues 1-32 / Troponin I residues 1-32 / : / Tropomyosins signature. / Troponin / Troponin domain superfamily / Troponin / Tropomyosin / Tropomyosin / EF-hand domain pair / : / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Actin / Actin family / Actin / EF-hand domain pair / EF-hand, calcium binding motif / ATPase, nucleotide binding domain / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair 類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / Tropomyosin alpha-1 chain / Troponin I, cardiac muscle / Troponin T, cardiac muscle / Troponin C, slow skeletal and cardiac muscles / Actin, alpha skeletal muscle 類似検索 - 構成要素生物種 Homo sapiens (ヒト)Oryctolagus cuniculus (ウサギ)手法 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 4.8 Å 詳細データ登録者 Fujii, T. / Yamada, Y. / Namba, K. 引用ジャーナル : Nat Commun / 年 : 2020タイトル : Cardiac muscle thin filament structures reveal calcium regulatory mechanism.著者 : Yurika Yamada / Keiichi Namba / Takashi Fujii / 要旨 : Contraction of striated muscles is driven by cyclic interactions of myosin head projecting from the thick filament with actin filament and is regulated by Ca released from sarcoplasmic reticulum. ... Contraction of striated muscles is driven by cyclic interactions of myosin head projecting from the thick filament with actin filament and is regulated by Ca released from sarcoplasmic reticulum. Muscle thin filament consists of actin, tropomyosin and troponin, and Ca binding to troponin triggers conformational changes of troponin and tropomyosin to allow actin-myosin interactions. However, the structural changes involved in this regulatory mechanism remain unknown. Here we report the structures of human cardiac muscle thin filament in the absence and presence of Ca by electron cryomicroscopy. Molecular models in the two states built based on available crystal structures reveal the structures of a C-terminal region of troponin I and an N-terminal region of troponin T in complex with the head-to-tail junction of tropomyosin together with the troponin core on actin filament. Structural changes of the thin filament upon Ca binding now reveal the mechanism of Ca regulation of muscle contraction. 履歴 登録 2019年8月3日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2020年1月15日 Provider : repository / タイプ : Initial release改定 1.1 2020年1月22日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name 改定 1.2 2024年3月27日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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