Flagellar hook protein FlgE superfamily / Flagellar hook protein FlgE / Flagellar basal body protein FlaE D2 domain / Flagellar basal body rod protein, conserved site / Flagellar hook-basal body protein, FlgE/F/G / Flagellar hook-basal body protein, FlgE/F/G-like / Flagella basal body rod proteins signature. / Flagellar basal body rod protein, N-terminal / Flagella basal body rod protein / Flagellar basal-body/hook protein, C-terminal domain / Flagellar basal body rod FlgEFG protein C-terminal 類似検索 - ドメイン・相同性
Flagellar hook protein FlgE / Flagellar hook protein FlgE 類似検索 - 構成要素
Japan Agency for Medical Research and Development (AMED)
JP19am0101117
日本
Japan Agency for Medical Research and Development (AMED)
JP17pc0101020
日本
引用
ジャーナル: Nat Commun / 年: 2019 タイトル: Structure of the native supercoiled flagellar hook as a universal joint. 著者: Takayuki Kato / Fumiaki Makino / Tomoko Miyata / Péter Horváth / Keiichi Namba / 要旨: The Bacterial flagellar hook is a short supercoiled tubular structure made from a helical assembly of the hook protein FlgE. The hook acts as a universal joint that connects the flagellar basal body ...The Bacterial flagellar hook is a short supercoiled tubular structure made from a helical assembly of the hook protein FlgE. The hook acts as a universal joint that connects the flagellar basal body and filament, and smoothly transmits torque generated by the rotary motor to the helical filament propeller. In peritrichously flagellated bacteria, the hook allows the filaments to form a bundle behind the cell for swimming, and for the bundle to fall apart for tumbling. Here we report a native supercoiled hook structure at 3.6 Å resolution by cryoEM single particle image analysis of the polyhook. The atomic model built into the three-dimensional (3D) density map reveals the changes in subunit conformation and intersubunit interactions that occur upon compression and extension of the 11 protofilaments during their smoke ring-like rotation. These observations reveal how the hook functions as a dynamic molecular universal joint with high bending flexibility and twisting rigidity.
#262 - 2021年10月 PDB構造への50年間のオープンアクセス (Fifty Years of Open Access to PDB Structures ) 類似性 (12)
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集合体
登録構造単位
A: Flagellar hook protein FlgE B: Flagellar hook protein FlgE C: Flagellar hook protein FlgE D: Flagellar hook protein FlgE E: Flagellar hook protein FlgE F: Flagellar hook protein FlgE G: Flagellar hook protein FlgE H: Flagellar hook protein FlgE I: Flagellar hook protein FlgE J: Flagellar hook protein FlgE K: Flagellar hook protein FlgE L: Flagellar hook protein FlgE M: Flagellar hook protein FlgE N: Flagellar hook protein FlgE O: Flagellar hook protein FlgE P: Flagellar hook protein FlgE Q: Flagellar hook protein FlgE R: Flagellar hook protein FlgE S: Flagellar hook protein FlgE T: Flagellar hook protein FlgE U: Flagellar hook protein FlgE V: Flagellar hook protein FlgE W: Flagellar hook protein FlgE X: Flagellar hook protein FlgE Y: Flagellar hook protein FlgE Z: Flagellar hook protein FlgE