- PDB-5xb1: human ferritin mutant - E-helix deletion -
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基本情報
登録情報
データベース: PDB / ID: 5xb1
タイトル
human ferritin mutant - E-helix deletion
要素
Ferritin heavy chain
キーワード
TRANSPORT PROTEIN / ferritin / cage / drug delivery
機能・相同性
機能・相同性情報
iron ion sequestering activity / : / autolysosome / Scavenging by Class A Receptors / Golgi Associated Vesicle Biogenesis / ferroxidase / intracellular sequestering of iron ion / ferroxidase activity / negative regulation of fibroblast proliferation / ferric iron binding ...iron ion sequestering activity / : / autolysosome / Scavenging by Class A Receptors / Golgi Associated Vesicle Biogenesis / ferroxidase / intracellular sequestering of iron ion / ferroxidase activity / negative regulation of fibroblast proliferation / ferric iron binding / Iron uptake and transport / ferrous iron binding / tertiary granule lumen / iron ion transport / intracellular iron ion homeostasis / ficolin-1-rich granule lumen / iron ion binding / immune response / negative regulation of cell population proliferation / Neutrophil degranulation / extracellular exosome / extracellular region / identical protein binding / membrane / nucleus / cytoplasm / cytosol 類似検索 - 分子機能
ジャーナル: Angew Chem Int Ed Engl / 年: 2018 タイトル: Four-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release. 著者: Byungjun Ahn / Seong-Gyu Lee / Hye Ryeon Yoon / Jeong Min Lee / Hyeok Jin Oh / Ho Min Kim / Yongwon Jung / 要旨: Human ferritins are emerging platforms for non-toxic protein-based drug delivery, owing to their intrinsic or acquirable targeting abilities to cancer cells and hollow cage structures for drug ...Human ferritins are emerging platforms for non-toxic protein-based drug delivery, owing to their intrinsic or acquirable targeting abilities to cancer cells and hollow cage structures for drug loading. However, reliable strategies for high-level drug encapsulation within ferritin cavities and prompt cellular drug release are still lacking. Ferritin nanocages were developed with partially opened hydrophobic channels, which provide stable routes for spontaneous and highly accumulated loading of Fe -conjugated drugs as well as pH-responsive rapid drug release at endoplasmic pH. Multiple cancer-related compounds, such as doxorubicin, curcumin, and quercetin, were actively and heavily loaded onto the prepared nicked ferritin. Drugs on these minimally modified ferritins were effectively delivered inside cancer cells with high toxicity.
A: Ferritin heavy chain B: Ferritin heavy chain C: Ferritin heavy chain D: Ferritin heavy chain E: Ferritin heavy chain F: Ferritin heavy chain G: Ferritin heavy chain H: Ferritin heavy chain I: Ferritin heavy chain J: Ferritin heavy chain K: Ferritin heavy chain L: Ferritin heavy chain M: Ferritin heavy chain N: Ferritin heavy chain O: Ferritin heavy chain P: Ferritin heavy chain Q: Ferritin heavy chain R: Ferritin heavy chain S: Ferritin heavy chain T: Ferritin heavy chain U: Ferritin heavy chain V: Ferritin heavy chain W: Ferritin heavy chain X: Ferritin heavy chain