- EMDB-40738: Structure of human ULK1C:PI3KC3-C1 supercomplex -
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Basic information
Entry
Database: EMDB / ID: EMD-40738
Title
Structure of human ULK1C:PI3KC3-C1 supercomplex
Map data
z-flipped from the original map
Sample
Complex: Supercomplex composed of ULK1 complex and PI3KC3-C1 complex
Complex: Human autophagy initiation ULK1 complex core
Protein or peptide: RB1-inducible coiled-coil protein 1
Protein or peptide: Serine/threonine-protein kinase ULK1
Protein or peptide: Autophagy-related protein 13
Complex: Human autophagy initiation PI3KC3-C1 complex
Protein or peptide: Phosphoinositide 3-kinase regulatory subunit 4
Protein or peptide: Phosphatidylinositol 3-kinase catalytic subunit type 3
Protein or peptide: Beclin 1-associated autophagy-related key regulator
Protein or peptide: Beclin-1-C 35 kDa
Keywords
Autophagy / Protein kinase / Lipid kinase / Supercomplex / IMMUNE SYSTEM
Function / homology
Function and homology information
extrinsic component of omegasome membrane / phosphatidylinositol 3-kinase inhibitor activity / regulation of triglyceride metabolic process / extrinsic component of phagophore assembly site membrane / nucleus-vacuole junction / cellular response to aluminum ion / Toll Like Receptor 9 (TLR9) Cascade / omegasome membrane / protein lipidation / regulation of protein lipidation ...extrinsic component of omegasome membrane / phosphatidylinositol 3-kinase inhibitor activity / regulation of triglyceride metabolic process / extrinsic component of phagophore assembly site membrane / nucleus-vacuole junction / cellular response to aluminum ion / Toll Like Receptor 9 (TLR9) Cascade / omegasome membrane / protein lipidation / regulation of protein lipidation / Synthesis of PIPs at the late endosome membrane / neuron projection regeneration / ribophagy / phosphatidylinositol 3-kinase complex, class III / Synthesis of PIPs at the early endosome membrane / phosphatidylinositol 3-kinase complex, class III, type II / positive regulation of stress granule assembly / cellular response to oxygen-glucose deprivation / phosphatidylinositol 3-kinase complex, class III, type I / glycophagy / negative regulation of collateral sprouting / Atg1/ULK1 kinase complex / mitochondria-associated endoplasmic reticulum membrane contact site / response to mitochondrial depolarisation / positive regulation of attachment of mitotic spindle microtubules to kinetochore / cytoplasmic side of mitochondrial outer membrane / negative regulation of lysosome organization / positive regulation by host of viral genome replication / Synthesis of PIPs at the Golgi membrane / engulfment of apoptotic cell / nucleophagy / positive regulation of autophagosome assembly / negative regulation of autophagosome assembly / receptor catabolic process / regulation of protein complex stability / phosphatidylinositol kinase activity / protein localization to phagophore assembly site / phagophore assembly site membrane / suppression by virus of host autophagy / protein targeting to lysosome / protein targeting to vacuole / early endosome to late endosome transport / piecemeal microautophagy of the nucleus / cellular response to nitrogen starvation / late endosome to vacuole transport / SMAD protein signal transduction / RAB GEFs exchange GTP for GDP on RABs / protein kinase regulator activity / regulation of tumor necrosis factor-mediated signaling pathway / phagophore assembly site / Translation of Replicase and Assembly of the Replication Transcription Complex / axon extension / negative regulation of programmed cell death / response to iron(II) ion / TBC/RABGAPs / reticulophagy / positive regulation of protein targeting to mitochondrion / autolysosome / phosphatidylinositol 3-kinase / phosphatidylinositol-3-phosphate biosynthetic process / post-transcriptional regulation of gene expression / mitotic metaphase chromosome alignment / Macroautophagy / 1-phosphatidylinositol-3-kinase activity / autophagosome membrane docking / Receptor Mediated Mitophagy / RSV-host interactions / lysosome organization / endosome to lysosome transport / cytoplasmic pattern recognition receptor signaling pathway / positive regulation of cardiac muscle hypertrophy / response to starvation / p38MAPK cascade / axoneme / autophagosome membrane / cellular response to nutrient levels / phosphatidylinositol-mediated signaling / phosphatidylinositol phosphate biosynthetic process / mitophagy / autophagosome maturation / positive regulation of cell size / autophagosome assembly / PI3K Cascade / RHO GTPases Activate NADPH Oxidases / response to vitamin E / negative regulation of reactive oxygen species metabolic process / autophagosome / neuron development / regulation of macroautophagy / amyloid-beta metabolic process / negative regulation of protein-containing complex assembly / cellular defense response / cellular response to glucose starvation / positive regulation of autophagy / phosphatidylinositol 3-kinase binding / positive regulation of intrinsic apoptotic signaling pathway / extrinsic apoptotic signaling pathway / protein-membrane adaptor activity / JNK cascade / phagocytic vesicle Similarity search - Function
UV radiation resistance protein/autophagy-related protein 14 / Vacuolar sorting 38 and autophagy-related subunit 14 / Serine/threonine-protein kinase Vps15-like / Autophagy-related protein 11, C-terminal / Autophagy-related protein 11 / Autophagy-related protein 11 / Serine/threonine-protein kinase, Ulk1/Ulk2 / : / ATG1-like, MIT domain 2 / Beclin-1, BH3 domain ...UV radiation resistance protein/autophagy-related protein 14 / Vacuolar sorting 38 and autophagy-related subunit 14 / Serine/threonine-protein kinase Vps15-like / Autophagy-related protein 11, C-terminal / Autophagy-related protein 11 / Autophagy-related protein 11 / Serine/threonine-protein kinase, Ulk1/Ulk2 / : / ATG1-like, MIT domain 2 / Beclin-1, BH3 domain / Beclin-1 BH3 domain, Bcl-2-interacting / Autophagy-related protein 13, N-terminal / Autophagy-related protein 13 / Autophagy-related protein 13 / Serine/threonine-protein kinase Atg1-like, tMIT domain / Atg1-like, MIT domain 1 / Serine/threonine-protein kinase Atg1-like / Atg6/Beclin / Atg6/Beclin C-terminal domain superfamily / Atg6, BARA domain / Atg6/beclin, coiled-coil domain / Apg6 BARA domain / Apg6 coiled-coil region / Phosphatidylinositol 3-kinase, Vps34 type / HORMA domain superfamily / HEAT repeat profile. / HEAT, type 2 / Phosphoinositide 3-kinase C2 / Phosphoinositide 3-kinase, region postulated to contain C2 domain / C2 phosphatidylinositol 3-kinase-type domain / C2 phosphatidylinositol 3-kinase (PI3K)-type domain profile. / Phosphoinositide 3-kinase, accessory (PIK) domain superfamily / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase, accessory (PIK) domain / Phosphatidylinositol kinase / PIK helical domain profile. / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily / Phosphoinositide 3-kinase, catalytic domain / Phosphatidylinositol 3- and 4-kinase / Phosphatidylinositol 3- and 4-kinases catalytic domain profile. / Phosphatidylinositol 3-/4-kinase, catalytic domain / C2 domain superfamily / Armadillo-like helical / Armadillo-type fold / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / WD40/YVTN repeat-like-containing domain superfamily / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology
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