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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1igl | ||||||
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タイトル | SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR II RELATIONSHIP TO RECEPTOR AND BINDING PROTEIN INTERACTIONS | ||||||
![]() | INSULIN-LIKE GROWTH FACTOR II | ||||||
![]() | GROWTH FACTOR | ||||||
機能・相同性 | ![]() embryonic placenta morphogenesis / positive regulation of skeletal muscle tissue growth / negative regulation of muscle cell differentiation / regulation of muscle cell differentiation / Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) / IRS-related events triggered by IGF1R / positive regulation of organ growth / genomic imprinting / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of multicellular organism growth ...embryonic placenta morphogenesis / positive regulation of skeletal muscle tissue growth / negative regulation of muscle cell differentiation / regulation of muscle cell differentiation / Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) / IRS-related events triggered by IGF1R / positive regulation of organ growth / genomic imprinting / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of multicellular organism growth / exocrine pancreas development / positive regulation of vascular endothelial cell proliferation / positive regulation of activated T cell proliferation / positive regulation of cell division / positive regulation of insulin receptor signaling pathway / positive regulation of glycogen biosynthetic process / embryonic placenta development / SHC-related events triggered by IGF1R / insulin-like growth factor receptor binding / striated muscle cell differentiation / positive regulation of mitotic nuclear division / insulin-like growth factor receptor signaling pathway / platelet alpha granule lumen / protein serine/threonine kinase activator activity / animal organ morphogenesis / insulin receptor binding / growth factor activity / hormone activity / glucose metabolic process / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / osteoblast differentiation / integrin binding / insulin receptor signaling pathway / Platelet degranulation / in utero embryonic development / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of MAPK cascade / receptor ligand activity / positive regulation of cell population proliferation / regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | 溶液NMR | ||||||
![]() | Torres, A.M. / Forbes, B.E. / Aplin, S.E. / Wallace, J.C. / Francis, G.L. / Norton, R.S. | ||||||
![]() | ![]() タイトル: Solution structure of human insulin-like growth factor II. Relationship to receptor and binding protein interactions. 著者: Torres, A.M. / Forbes, B.E. / Aplin, S.E. / Wallace, J.C. / Francis, G.L. / Norton, R.S. #2: ![]() タイトル: Tertiary Structures, Receptor Binding, and Antigenicity of Insulinlike Growth Factors 著者: Blundell, T.L. / Bedarkar, S. / Humbel, R.E. #3: ![]() タイトル: Insulin-Like Growth Factor: A Model for Tertiary Structure Accounting for Immmunoreactivity and Receptor Binding 著者: Blundell, T.L. / Bedarkar, S. / Rinderknecht, E. / Humbel, R.E. | ||||||
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 401.4 KB | 表示 | ![]() |
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PDB形式 | ![]() | 332.6 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 355.5 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 517.8 KB | 表示 | |
XML形式データ | ![]() | 31.5 KB | 表示 | |
CIF形式データ | ![]() | 49.9 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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1 |
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Atom site foot note | 1: ARG 30 - PRO 31 MODEL 5 OMEGA = 213.63 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION 2: ARG 3 - PRO 4 MODEL 13 OMEGA = 148.68 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION 3: THR 62 - PRO 63 MODEL 18 OMEGA = 148.91 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION | |||||||||
NMR アンサンブル |
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要素
#1: タンパク質 | 分子量: 7484.472 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() |
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Has protein modification | Y |
-実験情報
-実験
実験 | 手法: 溶液NMR |
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試料調製
結晶化 | *PLUS 手法: other / 詳細: NMR |
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解析
ソフトウェア |
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NMR software | 名称: ![]() | ||||||||
NMRアンサンブル | 登録したコンフォーマーの数: 20 |