Entry | Database: PDB / ID: 8htb |
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Title | Staphylococcus aureus FtsZ 12-316 complexed with TXH9179 |
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Components | Cell division protein FtsZ |
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Keywords | HYDROLASE / GTPase / protein-inhibitor complex / antibacterial agent |
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Function / homology | Function and homology information
chloroplast fission / FtsZ-dependent cytokinesis / division septum assembly / cell division site / protein polymerization / GTPase activity / GTP binding / cytoplasmSimilarity search - Function Tubulin-like protein FtsZ/CetZ / Cell division protein FtsZ / Cell division protein FtsZ, conserved site / Cell division protein FtsZ, C-terminal / FtsZ family, C-terminal domain / FtsZ protein signature 1. / FtsZ protein signature 2. / Tubulin/FtsZ family, C-terminal domain / Tubulin/FtsZ-like, C-terminal domain / Tubulin/FtsZ, C-terminal ...Tubulin-like protein FtsZ/CetZ / Cell division protein FtsZ / Cell division protein FtsZ, conserved site / Cell division protein FtsZ, C-terminal / FtsZ family, C-terminal domain / FtsZ protein signature 1. / FtsZ protein signature 2. / Tubulin/FtsZ family, C-terminal domain / Tubulin/FtsZ-like, C-terminal domain / Tubulin/FtsZ, C-terminal / Tubulin/FtsZ, 2-layer sandwich domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ, GTPase domain / Tubulin/FtsZ, GTPase domain superfamilySimilarity search - Domain/homology |
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Biological species | Staphylococcus aureus (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.3 Å |
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Authors | Bryan, E. / Ferrer-Gonzalez, E. / Sagong, H.Y. / Fujita, J. / Mark, L. / Kaul, M. / LaVoie, E.J. / Matsumura, H. / Pilch, D.S. |
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Funding support | United States, Japan, 11items Organization | Grant number | Country |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI118874 | United States | Japan Society for the Promotion of Science (JSPS) | 15J00589 | Japan | Japan Society for the Promotion of Science (JSPS) | 16H00783 | Japan | Japan Society for the Promotion of Science (JSPS) | 18K06094 | Japan | Japan Society for the Promotion of Science (JSPS) | 19H04735 | Japan | Japan Society for the Promotion of Science (JSPS) | 19K07582 | Japan | Takeda Science Foundation | | Japan | The Promotion and Mutual Aid Corporation for Private Schools of Japan | | Japan | Institute for Protein Research, Osaka University | CR-18-05 | Japan | Institute for Protein Research, Osaka University | CR-19-05 | Japan | Japan Agency for Medical Research and Development (AMED) | JP19am0101070 | Japan |
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Citation | Journal: Acs Chem.Biol. / Year: 2023 Title: Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus. Authors: Bryan, E. / Ferrer-Gonzalez, E. / Sagong, H.Y. / Fujita, J. / Mark, L. / Kaul, M. / LaVoie, E.J. / Matsumura, H. / Pilch, D.S. |
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History | Deposition | Dec 21, 2022 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Sep 20, 2023 | Provider: repository / Type: Initial release |
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