登録情報 | データベース: PDB / ID: 7vtx |
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タイトル | Crystal structure of PDE8A catalytic domain in complex with 22 |
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要素 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
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キーワード | HYDROLASE / cAMP-specific / Selective PDE8A inhibitor |
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機能・相同性 | 機能・相同性情報
3',5'-cyclic-AMP phosphodiesterase / protein kinase activator activity / cAMP catabolic process / cellular response to epidermal growth factor stimulus / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cAMP-mediated signaling / kinase binding / G alpha (s) signalling events / positive regulation of ERK1 and ERK2 cascade ...3',5'-cyclic-AMP phosphodiesterase / protein kinase activator activity / cAMP catabolic process / cellular response to epidermal growth factor stimulus / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cAMP-mediated signaling / kinase binding / G alpha (s) signalling events / positive regulation of ERK1 and ERK2 cascade / regulation of DNA-templated transcription / perinuclear region of cytoplasm / extracellular exosome / nucleus / metal ion binding / cytosol類似検索 - 分子機能 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / PAS fold ...3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / PAS fold / PAS fold / PAS repeat profile. / PAS domain / PAS domain superfamily類似検索 - ドメイン・相同性 Chem-80D / High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.50010936848 Å |
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データ登録者 | Wu, X.-N. / Zhou, Q. / Huang, Y.-D. / Li, Z. / Wu, Y. / Luo, H.-B. |
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資金援助 | 中国, 2件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 21877134 | 中国 | National Natural Science Foundation of China (NSFC) | 22077143 | 中国 |
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引用 | ジャーナル: To Be Published タイトル: Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia 著者: Wu, X.-N. / Zhou, Q. / Huang, Y.-D. / Li, Z. / Wu, Y. / Luo, H.-B. |
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履歴 | 登録 | 2021年10月31日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年11月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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