登録情報 | データベース: PDB / ID: 7tb1 |
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タイトル | Crystal structure of STUB1 with a macrocyclic peptide |
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要素 | - ALA-CYS-SER-SER-ILE-TRP-CYS-PRO-ASP-GLY
- E3 ubiquitin-protein ligase CHIP
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キーワード | TRANSFERASE / E3 Ligase / carboxy-terminus of Hsp70-interacting protein |
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機能・相同性 | 機能・相同性情報
positive regulation of chaperone-mediated protein complex assembly / regulation of glucocorticoid metabolic process / ubiquitin conjugating enzyme complex / positive regulation of ERAD pathway / positive regulation of mitophagy / ERBB2 signaling pathway / positive regulation of smooth muscle cell apoptotic process / nuclear inclusion body / misfolded protein binding / R-SMAD binding ...positive regulation of chaperone-mediated protein complex assembly / regulation of glucocorticoid metabolic process / ubiquitin conjugating enzyme complex / positive regulation of ERAD pathway / positive regulation of mitophagy / ERBB2 signaling pathway / positive regulation of smooth muscle cell apoptotic process / nuclear inclusion body / misfolded protein binding / R-SMAD binding / cellular response to misfolded protein / protein folding chaperone complex / ubiquitin-ubiquitin ligase activity / RIPK1-mediated regulated necrosis / chaperone-mediated autophagy / protein quality control for misfolded or incompletely synthesized proteins / TPR domain binding / protein monoubiquitination / SMAD binding / negative regulation of smooth muscle cell apoptotic process / protein K63-linked ubiquitination / positive regulation of proteolysis / protein maturation / protein autoubiquitination / ERAD pathway / ubiquitin ligase complex / endoplasmic reticulum unfolded protein response / heat shock protein binding / Hsp70 protein binding / Downregulation of TGF-beta receptor signaling / negative regulation of transforming growth factor beta receptor signaling pathway / positive regulation of protein ubiquitination / response to ischemia / G protein-coupled receptor binding / Regulation of TNFR1 signaling / kinase binding / Downregulation of ERBB2 signaling / Hsp90 protein binding / RING-type E3 ubiquitin transferase / regulation of protein stability / tau protein binding / Regulation of necroptotic cell death / Z disc / Regulation of PTEN stability and activity / protein polyubiquitination / ubiquitin-protein transferase activity / Regulation of RUNX2 expression and activity / MAPK cascade / ubiquitin protein ligase activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Antigen processing: Ubiquitination & Proteasome degradation / cellular response to hypoxia / protein-macromolecule adaptor activity / protein-folding chaperone binding / cellular response to heat / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / protein stabilization / protein ubiquitination / DNA repair / ubiquitin protein ligase binding / enzyme binding / endoplasmic reticulum / protein homodimerization activity / mitochondrion / nucleoplasm / nucleus / cytoplasm / cytosol類似検索 - 分子機能 CHIP, N-terminal tetratricopeptide repeat domain / CHIP/LubX , U box domain / CHIP N-terminal tetratricopeptide repeat domain / Anaphase-promoting complex, cyclosome, subunit 3 / U-box domain / U-box domain profile. / Modified RING finger domain / U-box domain / TPR repeat region circular profile. / TPR repeat profile. ...CHIP, N-terminal tetratricopeptide repeat domain / CHIP/LubX , U box domain / CHIP N-terminal tetratricopeptide repeat domain / Anaphase-promoting complex, cyclosome, subunit 3 / U-box domain / U-box domain profile. / Modified RING finger domain / U-box domain / TPR repeat region circular profile. / TPR repeat profile. / Tetratricopeptide repeats / Tetratricopeptide repeat / Tetratricopeptide-like helical domain superfamily / Zinc finger, RING/FYVE/PHD-type類似検索 - ドメイン・相同性 1,3-bis(sulfanyl)propan-2-one / E3 ubiquitin-protein ligase CHIP類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.785 Å |
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データ登録者 | Bahmanjah, S. / Klein, D.J. |
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資金援助 | 1件 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2022 タイトル: Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1. 著者: Ng, S. / Brueckner, A.C. / Bahmanjah, S. / Deng, Q. / Johnston, J.M. / Ge, L. / Duggal, R. / Habulihaz, B. / Barlock, B. / Ha, S. / Sadruddin, A. / Yeo, C. / Strickland, C. / Peier, A. / ...著者: Ng, S. / Brueckner, A.C. / Bahmanjah, S. / Deng, Q. / Johnston, J.M. / Ge, L. / Duggal, R. / Habulihaz, B. / Barlock, B. / Ha, S. / Sadruddin, A. / Yeo, C. / Strickland, C. / Peier, A. / Henry, B. / Sherer, E.C. / Partridge, A.W. |
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履歴 | 登録 | 2021年12月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年7月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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