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- PDB-7ryo: CD1a-dideoxymycobactin-gdTCR complex -

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Basic information

Entry
Database: PDB / ID: 7ryo
TitleCD1a-dideoxymycobactin-gdTCR complex
Components
  • (T cell receptor ...) x 2
  • Beta-2-microglobulin
  • T-cell surface glycoprotein CD1a
KeywordsIMMUNE SYSTEM / CD1 / TCR / lipid antigen
Function / homology
Function and homology information


endogenous lipid antigen binding / exogenous lipid antigen binding / antigen processing and presentation, endogenous lipid antigen via MHC class Ib / antigen processing and presentation, exogenous lipid antigen via MHC class Ib / lipopeptide binding / alpha-beta T cell receptor complex / T cell receptor complex / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / alpha-beta T cell activation ...endogenous lipid antigen binding / exogenous lipid antigen binding / antigen processing and presentation, endogenous lipid antigen via MHC class Ib / antigen processing and presentation, exogenous lipid antigen via MHC class Ib / lipopeptide binding / alpha-beta T cell receptor complex / T cell receptor complex / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / alpha-beta T cell activation / Generation of second messenger molecules / PD-1 signaling / positive regulation of ferrous iron binding / positive regulation of transferrin receptor binding / positive regulation of receptor binding / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression / negative regulation of receptor binding / DAP12 interactions / cellular response to iron ion / Endosomal/Vacuolar pathway / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / response to bacterium / cellular response to iron(III) ion / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / negative regulation of forebrain neuron differentiation / regulation of erythrocyte differentiation / peptide antigen assembly with MHC class I protein complex / ER to Golgi transport vesicle membrane / regulation of iron ion transport / response to molecule of bacterial origin / MHC class I peptide loading complex / HFE-transferrin receptor complex / T cell mediated cytotoxicity / antigen processing and presentation of endogenous peptide antigen via MHC class I / positive regulation of T cell cytokine production / MHC class I protein complex / multicellular organismal-level iron ion homeostasis / negative regulation of neurogenesis / positive regulation of receptor-mediated endocytosis / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / cellular response to nicotine / positive regulation of T cell mediated cytotoxicity / specific granule lumen / recycling endosome membrane / phagocytic vesicle membrane / peptide antigen binding / positive regulation of cellular senescence / negative regulation of epithelial cell proliferation / antigen processing and presentation of exogenous peptide antigen via MHC class II / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Interferon gamma signaling / positive regulation of immune response / Modulation by Mtb of host immune system / positive regulation of T cell activation / sensory perception of smell / Downstream TCR signaling / negative regulation of neuron projection development / positive regulation of protein binding / tertiary granule lumen / DAP12 signaling / MHC class II protein complex binding / late endosome membrane / T cell receptor signaling pathway / iron ion transport / ER-Phagosome pathway / early endosome membrane / T cell differentiation in thymus / protein refolding / protein homotetramerization / intracellular iron ion homeostasis / adaptive immune response / amyloid fibril formation / learning or memory / endosome membrane / immune response / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / external side of plasma membrane / Golgi membrane / lysosomal membrane / innate immune response / focal adhesion / Neutrophil degranulation / SARS-CoV-2 activates/modulates innate and adaptive immune responses / structural molecule activity / Golgi apparatus / endoplasmic reticulum / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane / cytosol
Similarity search - Function
: / : / : / T-cell receptor alpha chain, constant domain / MHC-I family domain / Domain of unknown function (DUF1968) / : / : / Immunoglobulin V-Type / Beta-2-Microglobulin ...: / : / : / T-cell receptor alpha chain, constant domain / MHC-I family domain / Domain of unknown function (DUF1968) / : / : / Immunoglobulin V-Type / Beta-2-Microglobulin / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / Immunoglobulin V-set domain / MHC classes I/II-like antigen recognition protein / Immunoglobulin V-set domain / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
dideoxymycobactin-838 / T cell receptor gamma variable 4 / T cell receptor delta variable 1 / T cell receptor alpha chain constant / T cell receptor beta constant 1 / T-cell surface glycoprotein CD1a / Beta-2-microglobulin
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3 Å
AuthorsWegrecki, M. / Le Nours, J. / Rossjohn, J.
Funding support Australia, 1items
OrganizationGrant numberCountry
National Health and Medical Research Council (NHMRC, Australia) Australia
CitationJournal: Nat Commun / Year: 2022
Title: Atypical sideways recognition of CD1a by autoreactive gamma delta T cell receptors.
Authors: Wegrecki, M. / Ocampo, T.A. / Gunasinghe, S.D. / von Borstel, A. / Tin, S.Y. / Reijneveld, J.F. / Cao, T.P. / Gully, B.S. / Le Nours, J. / Moody, D.B. / Van Rhijn, I. / Rossjohn, J.
History
DepositionAug 25, 2021Deposition site: RCSB / Processing site: RCSB
Revision 1.0May 18, 2022Provider: repository / Type: Initial release
Revision 1.1Jul 13, 2022Group: Database references / Category: citation / citation_author
Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
Revision 1.2Oct 18, 2023Group: Data collection / Refinement description
Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: T-cell surface glycoprotein CD1a
B: Beta-2-microglobulin
C: T cell receptor gamma variable 4,T cell receptor beta constant 1
D: T cell receptor delta variable 1,T cell receptor alpha chain constant
hetero molecules


Theoretical massNumber of molelcules
Total (without water)97,8648
Polymers96,8054
Non-polymers1,0584
Water00
1


  • Idetical with deposited unit
  • defined by author&software
  • Evidence: surface plasmon resonance
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
Unit cell
Length a, b, c (Å)234.881, 42.239, 124.656
Angle α, β, γ (deg.)90.000, 113.348, 90.000
Int Tables number5
Space group name H-MC121
Space group name HallC2y
Symmetry operation#1: x,y,z
#2: -x,y,-z
#3: x+1/2,y+1/2,z
#4: -x+1/2,y+1/2,-z

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Components

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Protein , 2 types, 2 molecules AB

#1: Protein T-cell surface glycoprotein CD1a / T-cell surface antigen T6/Leu-6 / hTa1 thymocyte antigen


Mass: 32593.562 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: CD1A / Production host: Homo sapiens (human) / References: UniProt: P06126
#2: Protein Beta-2-microglobulin


Mass: 12602.105 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: B2M, CDABP0092, HDCMA22P / Production host: Homo sapiens (human) / References: UniProt: P61769

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T cell receptor ... , 2 types, 2 molecules CD

#3: Protein T cell receptor gamma variable 4,T cell receptor beta constant 1


Mass: 27987.078 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: TRGV4, TCRGV4, TRBC1 / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: A0A0C4DH28, UniProt: P01850
#4: Protein T cell receptor delta variable 1,T cell receptor alpha chain constant


Mass: 23622.590 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: TRDV1, TRAC, TCRA / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: A0A1B0GX56, UniProt: P01848

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Non-polymers , 3 types, 4 molecules

#5: Chemical ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL


Mass: 62.068 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C2H6O2
#6: Chemical ChemComp-WGR / dideoxymycobactin-838 / (2R)-4-oxo-4-{[(3S)-2-oxoazepan-3-yl]amino}butan-2-yl N~2~-[(4S)-2-(2-hydroxyphenyl)-4-methyl-4,5-dihydro-1,3-oxazole-4-carbonyl]-N~6~-[(2Z)-icos-2-enoyl]-L-lysinate


Mass: 838.127 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C47H75N5O8 / Feature type: SUBJECT OF INVESTIGATION
#7: Chemical ChemComp-SO4 / SULFATE ION


Mass: 96.063 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: SO4

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Details

Has ligand of interestY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.1 Å3/Da / Density % sol: 60.31 %
Crystal growTemperature: 293 K / Method: vapor diffusion, hanging drop / Details: 20% PEG 3350, 0.2M Ammonium sulfate

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: Australian Synchrotron / Beamline: MX2 / Wavelength: 0.95373 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Jun 23, 2020
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.95373 Å / Relative weight: 1
ReflectionResolution: 3→43.86 Å / Num. obs: 23043 / % possible obs: 99.7 % / Redundancy: 6.9 % / Biso Wilson estimate: 62.41 Å2 / CC1/2: 0.989 / Net I/σ(I): 6.5
Reflection shellResolution: 3→3.18 Å / Num. unique obs: 3638 / CC1/2: 0.703

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Processing

Software
NameVersionClassification
PHENIX1.19.2_4158refinement
XDSdata reduction
Aimlessdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 7RYM

7rym


Resolution: 3→39.96 Å / SU ML: 0.4371 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 31.2593
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2667 1151 5 %
Rwork0.2217 21873 -
obs0.224 23024 99.44 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 79.33 Å2
Refinement stepCycle: LAST / Resolution: 3→39.96 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6215 0 73 0 6288
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.0026462
X-RAY DIFFRACTIONf_angle_d0.55998815
X-RAY DIFFRACTIONf_chiral_restr0.0414953
X-RAY DIFFRACTIONf_plane_restr0.0041140
X-RAY DIFFRACTIONf_dihedral_angle_d13.59882242
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
3-3.140.38851300.33642671X-RAY DIFFRACTION99.29
3.14-3.30.33481520.29072676X-RAY DIFFRACTION99.37
3.3-3.510.34291320.25852758X-RAY DIFFRACTION99.42
3.51-3.780.29491480.24452692X-RAY DIFFRACTION99.51
3.78-4.160.27761410.21482707X-RAY DIFFRACTION99.48
4.16-4.760.22221390.1732751X-RAY DIFFRACTION99.59
4.76-5.990.24611490.1962773X-RAY DIFFRACTION99.93
5.99-39.960.21871600.20762845X-RAY DIFFRACTION99.01
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.44849078781-0.151819865911.228535331412.28578672234-1.051726954564.56032779891-0.07095965013330.108933768078-0.317493581196-0.2248407677140.208283827851-0.1117612737430.335178039013-0.413310654981-0.1494213595320.339942273705-0.004386506025410.1497846092010.348522880314-0.06093795349240.81106626557317.863190712410.0617669431-4.73406035086
20.8325850104741.40007234583-0.09593027850522.691154000620.06075176040160.95645034566-0.03462837491620.0956815082884-0.00266168327008-0.0414792882682-0.0166491715971-0.3130582573810.0562103278272-0.157721143611-0.09937995720320.379173743544-0.07243243778570.214348608976-0.04101041567250.05612724399471.0848181604151.814155503828.0910203857-1.04652187998
37.909307136221.0400104304-3.329712533252.051068335891.632305726813.64107272609-0.199697970361-0.739201697452-2.002653411450.0589341568723-1.165226093330.3099725851281.83078659132-0.1027663809131.345896262240.687600444841-0.05248331095480.08719241524570.5148521008740.2155568632771.2448235895532.8670344817.2562984377412.8047088064
43.34511185582-1.90477342033-0.8432092285834.388762066030.05601331308064.205423985640.00256853471966-0.3569162974430.57768486724-0.4385941058210.151932089778-1.03795079156-0.3074965140170.265523792138-0.1808726986020.4141223047470.101731344559-0.04134237906710.23076922382-0.008378994534640.78287345229141.807691169732.50300418357.98672692155
53.21906362064-1.075133392040.1814518476711.29586103568-0.6524332315822.53496709971-0.0308334060251-0.365020380692-0.2384360795080.2428412041390.395354098845-0.234716790353-0.10557960967-0.21215940062-0.2956584791840.117199032047-0.0313469821193-0.01013409030830.333457921133-0.07331393551160.45765678369835.597725889726.38652969578.1439857018
66.245364900761.37240203623-1.50904021894.482408923540.3491904975390.475827455230.0405350930269-0.592133370614-0.2693078919210.06923015178220.489733085197-0.0716731253980.477434261525-0.187828033411-0.5763735978680.6227851697280.0887027797495-0.1745140152260.3133049488440.1546587481290.64175139913326.762042109214.540374569113.7659450243
74.146238327513.287857635330.8827766013154.43392278464-2.212674453015.331375249380.197197870131-1.54610880090.7208848882240.412803309966-0.2568816180811.16720398794-0.195528936185-0.2162367852950.02082261847770.356010564253-0.05823684514590.07242033592640.523002191348-0.1430657616960.76358733574532.752741750231.087636683519.9248178293
83.357237404563.238295271783.403278524897.826013579417.57898238137.45775099877-0.2395056590780.105564223020.135562494727-0.739845946346-0.1564224357011.3631885136-0.925403196763-0.5248469042110.5209783557820.4477524228980.00815411784236-0.01276938943030.3275977524190.07362751183740.7380624141426.101682351324.96910209017.40931409067
93.86586731023.335501381212.060829518413.434471415243.03875954754.32250685840.05214935552240.1328678098080.366766424779-0.1723356853150.536788259163-0.4504434192590.2202378509750.196650438257-0.5864771637850.3099537639530.1000298179710.09836055115080.2939619411450.06333409245050.64749550742131.732894769422.06850257185.87001220796
103.15676350501-1.832482631660.02642453927921.68914127366-0.5577576957744.070471569220.611987424053-0.1894603371870.7638747709930.871884738069-0.373110272792-1.39870018603-0.8220630643820.521502695212-0.08769205039410.678907197037-0.02415716754820.07870193642480.23335032620.05382076078980.76917261530439.719456401733.523219059518.5572170652
117.560562430973.14139920423-5.740483514883.32070595578-0.2019406392677.307671615220.0172213027844-1.31872459375-1.670809214791.01770244327-0.449017187061-1.098237334160.8248398997680.1149085800420.4465338085660.536825159364-0.01357052317290.1098800343160.5512059282150.2674657818080.73378595662932.889570161214.194076173521.147752262
125.374260903255.25289287564-4.333465149065.20834922206-3.714172469737.23671732472-0.0828391787886-0.804900951973-0.229588068850.3659809740160.112127292479-1.79402785167-0.05670662732790.760868596839-0.04418236801340.4351239774970.031307368978-0.05055205762080.4272827295020.0168856715120.84183858547144.112549088528.493021387616.1587934435
131.886043897930.937345997591-0.6525666392832.29486252517-0.9616368374164.08172358845-0.101296552853-0.00676711342435-0.100244207838-0.05538822251560.09175379149670.1801981850240.138585928217-0.1958908769340.05646201746360.4358351507450.009287137377670.1340971760150.5757020561470.04223089392960.600737723371-1.688892039793.7856312115424.9298932313
141.846298051660.61589998962-0.9154883456581.63147575046-0.4292166665963.34793652449-0.0695841289866-0.35663585224-0.0848763707070.2642346939980.003041128400110.2112285715440.0693937336934-0.34157876988-0.0007623209116630.39319445150.0313272938710.1520421844580.5871590774490.1223371880870.676443396967-3.271220260154.5335127224436.6446359958
152.155509658780.1743799788090.424412894114.771014910782.844015741485.73888879220.220438348353-0.6135888568110.02756766883260.93993749331-0.03113101768360.0887608470257-0.2878179832910.287124223524-0.1600384708091.11645345692-0.1366515152310.04366145693161.034516877270.3528290719590.673825071518-9.919311366351.18676113963.7226761751
162.389977983460.9444461154450.6207443491442.88682660995-2.157963364832.48846754691-0.0855251684755-0.487628706121-0.01570558322760.665090289962-0.03410329988430.000641933200411-0.139238411773-0.1985560646290.04391252684041.25613445945-0.2213545168140.3074095593311.332677619710.2462649428320.569311082947-13.492333587210.534385337457.2119437522
171.57413030473-0.3641808338211.294226094992.502451233760.4142609938282.240346828590.155177999732-0.3230187341780.1668042317890.170035676471-0.02708914049390.198219528551-0.323632387471-0.176436608217-0.255693934410.818442624119-0.2032355636960.2472327587231.025514284250.09998305263740.65205779827-15.1758981042-0.79367061557554.2641798999
185.59102664067-2.40447948446-3.877833709613.570730593425.403524930478.191513295-0.233602610276-1.23790019426-0.2544960416770.8813886401990.271135685596-1.05017908381.983741956890.274305079905-0.0294735840610.9662141604690.05242319586330.03885146532061.11287447850.4030717735320.87313552036716.87717354255.3259410812843.7958173374
191.38125849679-0.9020173962592.360688623452.16810273050.2887879487626.23176696145-0.0758011643937-0.3949685027070.3380173396020.173747253607-0.0896746429877-0.513827015057-0.1548194859590.5873205508240.2020371013710.715499855261-0.2617649276510.01970682072811.138271502190.07812604065640.70885260277219.232272836611.579912018946.1773902239
202.78543377654-1.817211617172.06605843512.35779482840.6731446157155.070368110260.243567719084-0.3294049303630.280869060234-0.0936564713765-0.497848100359-0.3945303365660.005604494942391.108093305030.308595498550.547362999419-0.1922540324440.126538705990.8298572378330.08943885361520.81144037062116.910115604913.558948941532.1298559383
213.04567773271-1.603343435611.604327203722.774196961720.3663194258856.83999405615-0.250424644619-0.6225172007120.5257123941930.136402284552-0.343668832691-0.527077130756-0.898153984740.5532799601990.4254520934370.860458154769-0.2940147280450.1127392034360.864966489878-0.177229117770.89143843432613.53985981619.239009143238.6964403886
222.281056038612.16728135961-1.567257051342.06266509649-1.531988639611.696334200110.967290354736-1.266237444620.1301041350911.12098289979-0.784139753846-0.789193186151-0.1691646460521.27071799981-0.1529030230040.770430587721-0.330753505252-0.06340546410131.486205844790.1266163757060.98448612482222.660013559415.964712540341.75053296
233.442866421592.3306615439-1.520706891484.41486004778-1.163982764615.88520398571.25174860022-1.180970826490.4864060661471.30745265569-0.729942190801-0.0342166994687-0.2829198571730.512804949054-0.3350233384650.690121695334-0.3334175232620.01457112672771.26354831076-0.07635673164780.74821394563510.434979014613.718079846744.3219241775
243.723449167353.27347378002-3.380250554563.48705280213-1.679210813515.786727630880.145077357747-0.4225237063230.1270832300480.113494660629-0.186290934394-0.382422673780.1552539358390.417051430845-0.1211311512840.318161734941-0.03399158776510.01036439930390.8269826284650.1841825894050.53323695148814.58108249910.739438265927.3026990355
250.325995553772-0.4292830505690.3909412008081.25762195655-0.9241020865560.72103046645-0.448456350165-0.5982177550990.255007681520.2190707530651.068737064930.3905803568710.382318137937-0.328407941703-0.5923860845571.05444136895-0.284773611215-0.0005264783154241.97061951199-0.04321877180540.7192472638557.062699492019.8133236825562.1556535254
268.512051697941.1717594777-2.882305563669.82494822347-5.780488004693.97344724444-0.0531276659255-1.28199342908-0.1695506896810.624015307344-0.2593906377820.04550006271930.447114458240.6807286836560.4116716595841.09195666738-0.08406942071830.0105494848071.344569567230.1413452740910.620909333368-3.0586390017-4.6428178323965.6751596235
276.306137175021.95402307813-1.162785282546.95565958954-2.107056686979.103447605110.702268056548-1.028726034210.2072613547920.6559041543550.4171141379820.4891796196560.826350435399-0.624454029396-1.008422128180.98273275985-0.141631556349-0.1032499332931.196023481370.02911884000510.916280013117-3.04351831185-0.35807094294364.9501977093
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'A' and (resid 7 through 176 )AA7 - 1761 - 170
22chain 'A' and (resid 177 through 283 )AA177 - 283171 - 277
33chain 'B' and (resid 1 through 6 )BE1 - 61 - 6
44chain 'B' and (resid 7 through 20 )BE7 - 207 - 20
55chain 'B' and (resid 21 through 31 )BE21 - 3121 - 31
66chain 'B' and (resid 32 through 37 )BE32 - 3732 - 37
77chain 'B' and (resid 38 through 47 )BE38 - 4738 - 47
88chain 'B' and (resid 48 through 57 )BE48 - 5748 - 57
99chain 'B' and (resid 58 through 72 )BE58 - 7258 - 72
1010chain 'B' and (resid 73 through 83 )BE73 - 8373 - 83
1111chain 'B' and (resid 84 through 91 )BE84 - 9184 - 91
1212chain 'B' and (resid 92 through 99 )BE92 - 9992 - 99
1313chain 'C' and (resid 11 through 92 )CF11 - 921 - 82
1414chain 'C' and (resid 93 through 132 )CF93 - 13283 - 122
1515chain 'C' and (resid 133 through 158 )CF133 - 158123 - 148
1616chain 'C' and (resid 159 through 176 )CF159 - 176149 - 166
1717chain 'C' and (resid 177 through 248 )CF177 - 248167 - 238
1818chain 'D' and (resid 2 through 15 )DG2 - 151 - 14
1919chain 'D' and (resid 16 through 27 )DG16 - 2715 - 26
2020chain 'D' and (resid 28 through 41 )DG28 - 4127 - 40
2121chain 'D' and (resid 42 through 63 )DG42 - 6341 - 62
2222chain 'D' and (resid 64 through 79 )DG64 - 7963 - 78
2323chain 'D' and (resid 80 through 96 )DG80 - 9679 - 95
2424chain 'D' and (resid 97 through 108 )DG97 - 10896 - 107
2525chain 'D' and (resid 109 through 122 )DG109 - 122108 - 121
2626chain 'D' and (resid 123 through 161 )DG123 - 161122 - 160
2727chain 'D' and (resid 162 through 193 )DG162 - 193161 - 192

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