登録情報 | データベース: PDB / ID: 7ni3 |
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タイトル | CRYSTAL STRUCTURE OF NATIVE HUMAN MYELOPEROXIDASE IN COMPLEX WITH CPD 3 |
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要素 | (Myeloperoxidase) x 2 |
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キーワード | OXIDOREDUCTASE / COMPLEX / INHIBITOR |
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機能・相同性 | 機能・相同性情報
myeloperoxidase / hypochlorous acid biosynthetic process / Events associated with phagocytolytic activity of PMN cells / phagocytic vesicle lumen / response to gold nanoparticle / response to yeast / respiratory burst involved in defense response / low-density lipoprotein particle remodeling / response to food / azurophil granule ...myeloperoxidase / hypochlorous acid biosynthetic process / Events associated with phagocytolytic activity of PMN cells / phagocytic vesicle lumen / response to gold nanoparticle / response to yeast / respiratory burst involved in defense response / low-density lipoprotein particle remodeling / response to food / azurophil granule / defense response to fungus / response to mechanical stimulus / removal of superoxide radicals / secretory granule / hydrogen peroxide catabolic process / peroxidase activity / defense response / azurophil granule lumen / heparin binding / response to oxidative stress / response to lipopolysaccharide / lysosome / defense response to bacterium / intracellular membrane-bounded organelle / heme binding / chromatin binding / Neutrophil degranulation / negative regulation of apoptotic process / extracellular space / extracellular exosome / extracellular region / nucleoplasm / nucleus / metal ion binding類似検索 - 分子機能 Haem peroxidase, animal-type / Haem peroxidase domain superfamily, animal type / Animal haem peroxidase / Animal heme peroxidase superfamily profile. / Peroxidases proximal heme-ligand signature. / Haem peroxidase superfamily類似検索 - ドメイン・相同性 beta-D-mannopyranose / PROTOPORPHYRIN IX CONTAINING FE / Chem-UE8 / Myeloperoxidase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Sjogren, T. / Inghardt, T. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2022 タイトル: Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction. 著者: Inghardt, T. / Antonsson, T. / Ericsson, C. / Hovdal, D. / Johannesson, P. / Johansson, C. / Jurva, U. / Kajanus, J. / Kull, B. / Michaelsson, E. / Pettersen, A. / Sjogren, T. / Sorensen, H. ...著者: Inghardt, T. / Antonsson, T. / Ericsson, C. / Hovdal, D. / Johannesson, P. / Johansson, C. / Jurva, U. / Kajanus, J. / Kull, B. / Michaelsson, E. / Pettersen, A. / Sjogren, T. / Sorensen, H. / Westerlund, K. / Lindstedt, E.L. |
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履歴 | 登録 | 2021年2月11日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2022年2月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年4月20日 | Group: Database references / カテゴリ: citation / Item: _citation.title |
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改定 1.2 | 2022年8月31日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.title / _citation.year |
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改定 1.3 | 2022年9月7日 | Group: Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.4 | 2022年9月21日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.5 | 2024年1月31日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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