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-Structure paper
Title | Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 11485-11496, Year 2022 |
Publish date | Feb 11, 2021 (structure data deposition date) |
![]() | Inghardt, T. / Antonsson, T. / Ericsson, C. / Hovdal, D. / Johannesson, P. / Johansson, C. / Jurva, U. / Kajanus, J. / Kull, B. / Michaelsson, E. ...Inghardt, T. / Antonsson, T. / Ericsson, C. / Hovdal, D. / Johannesson, P. / Johansson, C. / Jurva, U. / Kajanus, J. / Kull, B. / Michaelsson, E. / Pettersen, A. / Sjogren, T. / Sorensen, H. / Westerlund, K. / Lindstedt, E.L. |
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Methods | X-ray diffraction |
Resolution | 2.1 - 2.11 Å |
Structure data | ![]() PDB-7ni1: ![]() PDB-7ni3: |
Chemicals | ![]() ChemComp-CL: ![]() ChemComp-HEM: ![]() ChemComp-CA: ![]() ChemComp-NAG: ![]() ChemComp-UEB: ![]() ChemComp-BMA: ![]() ChemComp-HOH: ![]() ChemComp-UE8: |
Source |
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![]() | OXIDOREDUCTASE / COMPLEX / INHIBITOR |