+Open data
-Basic information
Entry | Database: PDB / ID: 7kxt | ||||||
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Title | Crystal structure of human EED | ||||||
Components | Polycomb protein EED | ||||||
Keywords | GENE REGULATION / EED / WD40 / Structural Genomics / Structural Genomics Consortium / SGC | ||||||
Function / homology | Function and homology information ESC/E(Z) complex / spinal cord development / histone methyltransferase activity / Transcriptional Regulation by E2F6 / enzyme activator activity / Regulation of PTEN gene transcription / transcription corepressor binding / PRC2 methylates histones and DNA / Defective pyroptosis / HCMV Early Events ...ESC/E(Z) complex / spinal cord development / histone methyltransferase activity / Transcriptional Regulation by E2F6 / enzyme activator activity / Regulation of PTEN gene transcription / transcription corepressor binding / PRC2 methylates histones and DNA / Defective pyroptosis / HCMV Early Events / PKMTs methylate histone lysines / heterochromatin formation / Activation of anterior HOX genes in hindbrain development during early embryogenesis / chromosome / Oxidative Stress Induced Senescence / negative regulation of DNA-templated transcription / chromatin binding / negative regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / nucleus / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.15 Å | ||||||
Authors | Zhu, L. / Dong, A. / Du, D. / Liu, Y. / Luo, C. / Arrowsmith, C.H. / Edwards, A.M. / Min, J. / Structural Genomics Consortium (SGC) | ||||||
Citation | Journal: J.Med.Chem. / Year: 2021 Title: Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. Authors: Du, D. / Xu, D. / Zhu, L. / Stazi, G. / Zwergel, C. / Liu, Y. / Luo, Z. / Li, Y. / Zhang, Y. / Zhu, K. / Ding, Y. / Liu, J. / Fan, S. / Zhao, K. / Zhang, N. / Kong, X. / Jiang, H. / Chen, K. ...Authors: Du, D. / Xu, D. / Zhu, L. / Stazi, G. / Zwergel, C. / Liu, Y. / Luo, Z. / Li, Y. / Zhang, Y. / Zhu, K. / Ding, Y. / Liu, J. / Fan, S. / Zhao, K. / Zhang, N. / Kong, X. / Jiang, H. / Chen, K. / Zhao, K. / Valente, S. / Min, J. / Duan, W. / Luo, C. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7kxt.cif.gz | 308.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7kxt.ent.gz | 246.5 KB | Display | PDB format |
PDBx/mmJSON format | 7kxt.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7kxt_validation.pdf.gz | 669 KB | Display | wwPDB validaton report |
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Full document | 7kxt_full_validation.pdf.gz | 674.5 KB | Display | |
Data in XML | 7kxt_validation.xml.gz | 28 KB | Display | |
Data in CIF | 7kxt_validation.cif.gz | 39.6 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/kx/7kxt ftp://data.pdbj.org/pub/pdb/validation_reports/kx/7kxt | HTTPS FTP |
-Related structure data
Related structure data | 3jznS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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