登録情報 データベース : PDB / ID : 6ybt 構造の表示 ダウンロードとリンクタイトル Structure of a human 48S translational initiation complex - eIF3bgi 要素Eukaryotic translation initiation factor 3 subunit A Eukaryotic translation initiation factor 3 subunit B Eukaryotic translation initiation factor 3 subunit I 詳細キーワード TRANSLATION / eIF3 / ribosome / initiation complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
viral translational termination-reinitiation / eukaryotic translation initiation factor 3 complex, eIF3e / eukaryotic translation initiation factor 3 complex, eIF3m / translation reinitiation / IRES-dependent viral translational initiation / multi-eIF complex / formation of cytoplasmic translation initiation complex / eukaryotic translation initiation factor 3 complex / eukaryotic 43S preinitiation complex / cytoplasmic translational initiation ... viral translational termination-reinitiation / eukaryotic translation initiation factor 3 complex, eIF3e / eukaryotic translation initiation factor 3 complex, eIF3m / translation reinitiation / IRES-dependent viral translational initiation / multi-eIF complex / formation of cytoplasmic translation initiation complex / eukaryotic translation initiation factor 3 complex / eukaryotic 43S preinitiation complex / cytoplasmic translational initiation / eukaryotic 48S preinitiation complex / regulation of translational initiation / Formation of the ternary complex, and subsequently, the 43S complex / Ribosomal scanning and start codon recognition / Translation initiation complex formation / Formation of a pool of free 40S subunits / GTP hydrolysis and joining of the 60S ribosomal subunit / L13a-mediated translational silencing of Ceruloplasmin expression / translation initiation factor binding / translation initiation factor activity / translational initiation / negative regulation of ERK1 and ERK2 cascade / receptor tyrosine kinase binding / cytoplasmic stress granule / microtubule / molecular adaptor activity / postsynaptic density / mRNA binding / synapse / nucleolus / structural molecule activity / RNA binding / extracellular exosome / nucleoplasm / membrane / cytosol / cytoplasm 類似検索 - 分子機能 Eukaryotic translation initiation factor 3 subunit I / Eukaryotic translation initiation factor 3 subunit B / eIF3B, RNA recognition motif / Translation initiation factor, beta propellor-like domain / Eukaryotic translation initiation factor eIF2A / Eukaryotic translation initiation factor 3 subunit A / Anaphase-promoting complex subunit 4, WD40 domain / Anaphase-promoting complex subunit 4 WD40 domain / motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 / PCI domain ... Eukaryotic translation initiation factor 3 subunit I / Eukaryotic translation initiation factor 3 subunit B / eIF3B, RNA recognition motif / Translation initiation factor, beta propellor-like domain / Eukaryotic translation initiation factor eIF2A / Eukaryotic translation initiation factor 3 subunit A / Anaphase-promoting complex subunit 4, WD40 domain / Anaphase-promoting complex subunit 4 WD40 domain / motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 / PCI domain / Proteasome component (PCI) domain / PCI domain profile. / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / WD40 repeat, conserved site / Nucleotide-binding alpha-beta plait domain superfamily / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily 類似検索 - ドメイン・相同性 Eukaryotic translation initiation factor 3 subunit B / Eukaryotic translation initiation factor 3 subunit I / Eukaryotic translation initiation factor 3 subunit A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 6 Å 詳細データ登録者 Brito Querido, J. / Sokabe, M. / Kraatz, S. / Gordiyenko, Y. / Skehel, M. / Fraser, C. / Ramakrishnan, V. 資金援助 英国, 米国, 3件 詳細 詳細を隠す組織 認可番号 国 Wellcome Trust WTY096570 英国 Medical Research Council (MRC, United Kingdom) MC_U105184332 英国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R01GM092927 米国
引用ジャーナル : Science / 年 : 2020タイトル : Structure of a human 48 translational initiation complex.著者 : Jailson Brito Querido / Masaaki Sokabe / Sebastian Kraatz / Yuliya Gordiyenko / J Mark Skehel / Christopher S Fraser / V Ramakrishnan / 要旨 : A key step in translational initiation is the recruitment of the 43 preinitiation complex by the cap-binding complex [eukaryotic initiation factor 4F (eIF4F)] at the 5' end of messenger RNA (mRNA) to ... A key step in translational initiation is the recruitment of the 43 preinitiation complex by the cap-binding complex [eukaryotic initiation factor 4F (eIF4F)] at the 5' end of messenger RNA (mRNA) to form the 48 initiation complex (i.e., the 48). The 48 then scans along the mRNA to locate a start codon. To understand the mechanisms involved, we used cryo-electron microscopy to determine the structure of a reconstituted human 48 The structure reveals insights into early events of translation initiation complex assembly, as well as how eIF4F interacts with subunits of eIF3 near the mRNA exit channel in the 43 The location of eIF4F is consistent with a slotting model of mRNA recruitment and suggests that downstream mRNA is unwound at least in part by being "pulled" through the 40 subunit during scanning. 履歴 登録 2020年3月17日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2020年9月16日 Provider : repository / タイプ : Initial release改定 1.1 2024年5月22日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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