登録情報 | データベース: PDB / ID: 6wu8 |
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タイトル | Structure of human SHP2 in complex with inhibitor IACS-13909 |
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要素 | Tyrosine-protein phosphatase non-receptor type 11 |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / Phosphatase / Inhibitor / Complex / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
negative regulation of cortisol secretion / intestinal epithelial cell migration / microvillus organization / negative regulation of growth hormone secretion / genitalia development / multicellular organismal reproductive process / atrioventricular canal development / negative regulation of cell adhesion mediated by integrin / STAT5 Activation / Netrin mediated repulsion signals ...negative regulation of cortisol secretion / intestinal epithelial cell migration / microvillus organization / negative regulation of growth hormone secretion / genitalia development / multicellular organismal reproductive process / atrioventricular canal development / negative regulation of cell adhesion mediated by integrin / STAT5 Activation / Netrin mediated repulsion signals / positive regulation of hormone secretion / cerebellar cortex formation / regulation of protein export from nucleus / positive regulation of ossification / hormone metabolic process / Interleukin-37 signaling / negative regulation of chondrocyte differentiation / Signaling by Leptin / MET activates PTPN11 / Regulation of RUNX1 Expression and Activity / face morphogenesis / ERBB signaling pathway / Costimulation by the CD28 family / Signal regulatory protein family interactions / peptide hormone receptor binding / platelet formation / megakaryocyte development / negative regulation of type I interferon production / organ growth / triglyceride metabolic process / CTLA4 inhibitory signaling / Platelet sensitization by LDL / Interleukin-20 family signaling / PI-3K cascade:FGFR3 / Interleukin-6 signaling / STAT5 activation downstream of FLT3 ITD mutants / PI-3K cascade:FGFR2 / Prolactin receptor signaling / PI-3K cascade:FGFR4 / PI-3K cascade:FGFR1 / MAPK3 (ERK1) activation / PECAM1 interactions / MAPK1 (ERK2) activation / regulation of cell adhesion mediated by integrin / regulation of type I interferon-mediated signaling pathway / Bergmann glial cell differentiation / phosphoprotein phosphatase activity / inner ear development / neurotrophin TRK receptor signaling pathway / platelet-derived growth factor receptor signaling pathway / non-membrane spanning protein tyrosine phosphatase activity / RET signaling / peptidyl-tyrosine dephosphorylation / Interleukin-3, Interleukin-5 and GM-CSF signaling / Regulation of IFNA/IFNB signaling / PI3K Cascade / PD-1 signaling / regulation of protein-containing complex assembly / ephrin receptor signaling pathway / fibroblast growth factor receptor signaling pathway / GAB1 signalosome / Activated NTRK2 signals through FRS2 and FRS3 / negative regulation of insulin secretion / Regulation of IFNG signaling / positive regulation of insulin receptor signaling pathway / FRS-mediated FGFR3 signaling / Signaling by CSF3 (G-CSF) / Signaling by FLT3 ITD and TKD mutants / homeostasis of number of cells within a tissue / FRS-mediated FGFR2 signaling / FRS-mediated FGFR4 signaling / Tie2 Signaling / FRS-mediated FGFR1 signaling / cellular response to epidermal growth factor stimulus / GPVI-mediated activation cascade / cell adhesion molecule binding / T cell costimulation / FLT3 Signaling / positive regulation of interferon-beta production / hormone-mediated signaling pathway / phosphotyrosine residue binding / protein dephosphorylation / Downstream signal transduction / positive regulation of mitotic cell cycle / protein-tyrosine-phosphatase / protein tyrosine kinase binding / axonogenesis / Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) / DNA damage checkpoint signaling / protein tyrosine phosphatase activity / integrin-mediated signaling pathway / positive regulation of glucose import / Negative regulation of FGFR3 signaling / Negative regulation of FGFR2 signaling / Negative regulation of FGFR4 signaling / Negative regulation of FGFR1 signaling / insulin receptor binding / Spry regulation of FGF signaling / brain development / epidermal growth factor receptor signaling pathway類似検索 - 分子機能 Protein-tyrosine phosphatase, non-receptor type-6, -11 / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / Tyrosine-specific protein phosphatases domain ...Protein-tyrosine phosphatase, non-receptor type-6, -11 / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily類似検索 - ドメイン・相同性 Chem-U9Y / Tyrosine-protein phosphatase non-receptor type 11類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | Leonard, P.G. / Joseph, S. / Rodenberger, A. |
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引用 | ジャーナル: Cancer Res. / 年: 2020 タイトル: Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. 著者: Sun, Y. / Meyers, B.A. / Czako, B. / Leonard, P. / Mseeh, F. / Harris, A.L. / Wu, Q. / Johnson, S. / Parker, C.A. / Cross, J.B. / Di Francesco, M.E. / Bivona, B.J. / Bristow, C.A. / Burke, J. ...著者: Sun, Y. / Meyers, B.A. / Czako, B. / Leonard, P. / Mseeh, F. / Harris, A.L. / Wu, Q. / Johnson, S. / Parker, C.A. / Cross, J.B. / Di Francesco, M.E. / Bivona, B.J. / Bristow, C.A. / Burke, J.P. / Carrillo, C.C. / Carroll, C.L. / Chang, Q. / Feng, N. / Gao, G. / Gera, S. / Giuliani, V. / Huang, J.K. / Jiang, Y. / Kang, Z. / Kovacs, J.J. / Liu, C.Y. / Lopez, A.M. / Ma, X. / Mandal, P.K. / McAfoos, T. / Miller, M.A. / Mullinax, R.A. / Peoples, M. / Ramamoorthy, V. / Seth, S. / Spencer, N.D. / Suzuki, E. / Williams, C.C. / Yu, S.S. / Zuniga, A.M. / Draetta, G.F. / Marszalek, J.R. / Heffernan, T.P. / Kohl, N.E. / Jones, P. |
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履歴 | 登録 | 2020年5月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年3月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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