登録情報 | データベース: PDB / ID: 6w9k |
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タイトル | Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with Prednisolone and PGC1a coregulator fragment |
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要素 | - Glucocorticoid Receptor
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
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キーワード | HORMONE / Glucocorticoid Receptor / anti-inflammation drug |
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機能・相同性 | 機能・相同性情報
Regulation of MITF-M dependent genes involved in metabolism / positive regulation of fatty acid oxidation / response to muscle activity / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / cellular respiration / lncRNA binding / digestion / temperature homeostasis / response to starvation / intracellular glucose homeostasis ...Regulation of MITF-M dependent genes involved in metabolism / positive regulation of fatty acid oxidation / response to muscle activity / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / cellular respiration / lncRNA binding / digestion / temperature homeostasis / response to starvation / intracellular glucose homeostasis / fatty acid oxidation / response to dietary excess / Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 / estrogen response element binding / adipose tissue development / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / brown fat cell differentiation / nuclear receptor-mediated steroid hormone signaling pathway / energy homeostasis / transcription coregulator activity / positive regulation of gluconeogenesis / respiratory electron transport chain / RNA splicing / negative regulation of smooth muscle cell proliferation / SUMOylation of transcription cofactors / nuclear receptor coactivator activity / mitochondrion organization / gluconeogenesis / nuclear receptor binding / regulation of circadian rhythm / transcription initiation at RNA polymerase II promoter / PPARA activates gene expression / positive regulation of DNA-binding transcription factor activity / circadian regulation of gene expression / Heme signaling / Transcriptional activation of mitochondrial biogenesis / Transcriptional regulation of white adipocyte differentiation / PML body / chromatin DNA binding / nuclear receptor activity / mRNA processing / Regulation of RUNX2 expression and activity / Circadian Clock / positive regulation of cold-induced thermogenesis / cellular response to oxidative stress / DNA-binding transcription factor binding / protein-containing complex assembly / neuron apoptotic process / sequence-specific DNA binding / transcription coactivator activity / negative regulation of neuron apoptotic process / RNA polymerase II-specific DNA-binding transcription factor binding / protein stabilization / ubiquitin protein ligase binding / positive regulation of gene expression / positive regulation of DNA-templated transcription / chromatin / regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / nucleoplasm / nucleus / cytosol類似検索 - 分子機能 PGC-1alpha, RNA recognition motif / PGC-1 / : / RNA recognition motif / RNA recognition motif / Nuclear hormone receptor / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily ...PGC-1alpha, RNA recognition motif / PGC-1 / : / RNA recognition motif / RNA recognition motif / Nuclear hormone receptor / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / RNA-binding domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nucleotide-binding alpha-beta plait domain superfamily類似検索 - ドメイン・相同性 prednisolone / Ancestral Glucocorticoid Receptor2 / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha類似検索 - 構成要素 |
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生物種 | synthetic construct (人工物)
Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.6 Å |
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データ登録者 | Liu, X. / Ortlund, E.A. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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American Heart Association | 17POST33660110 | 米国 | National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) | R01DK095750 | 米国 |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2020 タイトル: Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment. 著者: Liu, X. / Wang, Y. / Gutierrez, J.S. / Damsker, J.M. / Nagaraju, K. / Hoffman, E.P. / Ortlund, E.A. |
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履歴 | 登録 | 2020年3月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年11月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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