Entry | Database: PDB / ID: 6vsw |
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Title | Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORgt |
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Components | RAR-related orphan receptor C |
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Keywords | NUCLEAR PROTEIN / Nuclear Receptor RORgt |
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Function / homology | Function and homology information
multicellular organism development / ligand-activated transcription factor activity / cellular response to sterol / T-helper 17 cell differentiation / regulation of steroid metabolic process / Peyer's patch development / positive regulation of circadian rhythm / oxysterol binding / T-helper cell differentiation / RUNX3 Regulates Immune Response and Cell Migration ...multicellular organism development / ligand-activated transcription factor activity / cellular response to sterol / T-helper 17 cell differentiation / regulation of steroid metabolic process / Peyer's patch development / positive regulation of circadian rhythm / oxysterol binding / T-helper cell differentiation / RUNX3 Regulates Immune Response and Cell Migration / negative regulation of thymocyte apoptotic process / regulation of fat cell differentiation / regulation of glucose metabolic process / lymph node development / adipose tissue development / xenobiotic metabolic process / DNA-binding transcription repressor activity, RNA polymerase II-specific / circadian regulation of gene expression / Nuclear Receptor transcription pathway / circadian rhythm / nuclear receptor activity / sequence-specific double-stranded DNA binding / Interleukin-4 and Interleukin-13 signaling / sequence-specific DNA binding / DNA-binding transcription factor activity, RNA polymerase II-specific / nuclear body / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / chromatin / negative regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / nucleusSimilarity search - Function Nuclear receptor ROR / Retinoid-related orphan receptors, DNA-binding domain / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors ...Nuclear receptor ROR / Retinoid-related orphan receptors, DNA-binding domain / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Ligand-binding domain of nuclear hormone receptor / Orthogonal Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.202 Å |
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Authors | Spurlino, J. / Milligan, C. |
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Citation | Journal: Bioorg.Med.Chem.Lett. / Year: 2020 Title: Optimization and biological evaluation of thiazole-bis-amide inverse agonists of ROR gamma t. Authors: Gege, C. / Albers, M. / Kinzel, O. / Kleymann, G. / Schluter, T. / Steeneck, C. / Hoffmann, T. / Xue, X. / Cummings, M.D. / Spurlino, J. / Milligan, C. / Fourie, A.M. / Edwards, J.P. / ...Authors: Gege, C. / Albers, M. / Kinzel, O. / Kleymann, G. / Schluter, T. / Steeneck, C. / Hoffmann, T. / Xue, X. / Cummings, M.D. / Spurlino, J. / Milligan, C. / Fourie, A.M. / Edwards, J.P. / Leonard, K. / Coe, K. / Scott, B. / Pippel, D. / Goldberg, S.D. |
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History | Deposition | Feb 12, 2020 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | May 13, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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