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- PDB-6sma: Crystal structure of Human Neutrophil Elastase (HNE) in complex w... -
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Basic information
Entry | Database: PDB / ID: 6sma | ||||||||||||||||||
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Title | Crystal structure of Human Neutrophil Elastase (HNE) in complex with the 3-Oxo-beta-Sultam inhibitor LMC249 | ||||||||||||||||||
![]() | Neutrophil elastase | ||||||||||||||||||
![]() | HYDROLASE / Serine Hydrolases / Human Neutrophil Elastase / Inhibitor / 3-Oxo-beta-Sultams / Sulfonylation | ||||||||||||||||||
Function / homology | ![]() leukocyte elastase / biosynthetic process of antibacterial peptides active against Gram-negative bacteria / neutrophil-mediated killing of fungus / acute inflammatory response to antigenic stimulus / negative regulation of chemotaxis / positive regulation of leukocyte tethering or rolling / response to yeast / leukocyte migration involved in inflammatory response / negative regulation of interleukin-8 production / negative regulation of chemokine production ...leukocyte elastase / biosynthetic process of antibacterial peptides active against Gram-negative bacteria / neutrophil-mediated killing of fungus / acute inflammatory response to antigenic stimulus / negative regulation of chemotaxis / positive regulation of leukocyte tethering or rolling / response to yeast / leukocyte migration involved in inflammatory response / negative regulation of interleukin-8 production / negative regulation of chemokine production / Antimicrobial peptides / pyroptotic inflammatory response / Activation of Matrix Metalloproteinases / neutrophil-mediated killing of gram-negative bacterium / cytokine binding / Collagen degradation / extracellular matrix disassembly / Pyroptosis / phagocytosis / response to UV / phagocytic vesicle / transcription repressor complex / Degradation of the extracellular matrix / secretory granule / Regulation of Complement cascade / positive regulation of interleukin-8 production / positive regulation of smooth muscle cell proliferation / positive regulation of MAP kinase activity / protein catabolic process / negative regulation of inflammatory response / intracellular calcium ion homeostasis / specific granule lumen / transcription corepressor activity / positive regulation of immune response / azurophil granule lumen / heparin binding / peptidase activity / protease binding / collagen-containing extracellular matrix / endopeptidase activity / response to lipopolysaccharide / defense response to bacterium / serine-type endopeptidase activity / Neutrophil degranulation / negative regulation of transcription by RNA polymerase II / cell surface / proteolysis / extracellular space / extracellular exosome / extracellular region / cytosol / cytoplasm Similarity search - Function | ||||||||||||||||||
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Method | ![]() ![]() ![]() ![]() | ||||||||||||||||||
![]() | Brito, J.A. / Almeida, V.T. / Carvalho, L.M. / Moreira, R. / Archer, M. | ||||||||||||||||||
Funding support | ![]()
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![]() | ![]() Title: 3-Oxo-beta-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling. Authors: Carvalho, L.A.R. / Almeida, V.T. / Brito, J.A. / Lum, K.M. / Oliveira, T.F. / Guedes, R.C. / Goncalves, L.M. / Lucas, S.D. / Cravatt, B.F. / Archer, M. / Moreira, R. | ||||||||||||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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PDBx/mmCIF format | ![]() | 452 KB | Display | ![]() |
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PDB format | ![]() | 314.7 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 6qbuC ![]() 6qenC ![]() 6qeoC ![]() 4ym9S C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Assembly
Deposited unit | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
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