Entry | Database: PDB / ID: 6qu7 |
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Title | Crystal structure of human DHODH in complex with BAY 2402234 |
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Components | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Keywords | OXIDOREDUCTASE / DHODH |
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Function / homology | Function and homology information
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ...pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / cytosolSimilarity search - Function Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel ...Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha BetaSimilarity search - Domain/homology ACETATE ION / FLAVIN MONONUCLEOTIDE / Chem-JJE / OROTIC ACID / Dihydroorotate dehydrogenase (quinone), mitochondrialSimilarity search - Component |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.52 Å |
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Authors | Friberg, A. / Gradl, S. |
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Citation | Journal: Leukemia / Year: 2019 Title: The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. Authors: Christian, S. / Merz, C. / Evans, L. / Gradl, S. / Seidel, H. / Friberg, A. / Eheim, A. / Lejeune, P. / Brzezinka, K. / Zimmermann, K. / Ferrara, S. / Meyer, H. / Lesche, R. / Stoeckigt, D. ...Authors: Christian, S. / Merz, C. / Evans, L. / Gradl, S. / Seidel, H. / Friberg, A. / Eheim, A. / Lejeune, P. / Brzezinka, K. / Zimmermann, K. / Ferrara, S. / Meyer, H. / Lesche, R. / Stoeckigt, D. / Bauser, M. / Haegebarth, A. / Sykes, D.B. / Scadden, D.T. / Losman, J.A. / Janzer, A. |
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History | Deposition | Feb 26, 2019 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jun 5, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 16, 2019 | Group: Data collection / Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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Revision 1.2 | May 15, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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