登録情報 | データベース: PDB / ID: 6pz4 |
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タイトル | co-crystal structure of BACE with inhibitor AM-6494 |
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要素 | Beta-secretase 1 |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / BACE / inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.85 Å |
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データ登録者 | Huang, X. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2020 タイトル: Discovery of AM-6494: A Potent and Orally Efficacious beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2. 著者: Pettus, L.H. / Bourbeau, M.P. / Bradley, J. / Bartberger, M.D. / Chen, K. / Hickman, D. / Johnson, M. / Liu, Q. / Manning, J.R. / Nanez, A. / Siegmund, A.C. / Wen, P.H. / Whittington, D.A. / ...著者: Pettus, L.H. / Bourbeau, M.P. / Bradley, J. / Bartberger, M.D. / Chen, K. / Hickman, D. / Johnson, M. / Liu, Q. / Manning, J.R. / Nanez, A. / Siegmund, A.C. / Wen, P.H. / Whittington, D.A. / Allen, J.R. / Wood, S. |
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履歴 | 登録 | 2019年7月31日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年10月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年10月30日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.title / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2020年3月25日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.identifier_ORCID |
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