登録情報 | データベース: PDB / ID: 6ny4 |
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タイトル | Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor |
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要素 | Tyrosine-protein kinase JAK3 |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
negative regulation of dendritic cell cytokine production / negative regulation of FasL production / response to interleukin-9 / response to interleukin-2 / response to interleukin-15 / response to interleukin-4 / negative regulation of T-helper 1 cell differentiation / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway ...negative regulation of dendritic cell cytokine production / negative regulation of FasL production / response to interleukin-9 / response to interleukin-2 / response to interleukin-15 / response to interleukin-4 / negative regulation of T-helper 1 cell differentiation / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / interleukin-4-mediated signaling pathway / negative regulation of T cell activation / interleukin-2-mediated signaling pathway / regulation of T cell apoptotic process / negative regulation of interleukin-12 production / interleukin-15-mediated signaling pathway / tyrosine phosphorylation of STAT protein / negative regulation of thymocyte apoptotic process / Interleukin-15 signaling / Interleukin-2 signaling / regulation of receptor signaling pathway via JAK-STAT / growth hormone receptor binding / extrinsic component of plasma membrane / Signaling by ALK / Interleukin-20 family signaling / negative regulation of interleukin-10 production / enzyme-linked receptor protein signaling pathway / T cell homeostasis / extrinsic component of cytoplasmic side of plasma membrane / cell surface receptor signaling pathway via JAK-STAT / growth hormone receptor signaling pathway via JAK-STAT / Interleukin receptor SHC signaling / Interleukin-7 signaling / B cell differentiation / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / cytokine-mediated signaling pathway / peptidyl-tyrosine phosphorylation / RAF/MAP kinase cascade / protein phosphatase binding / protein tyrosine kinase activity / Interleukin-4 and Interleukin-13 signaling / regulation of apoptotic process / adaptive immune response / Potential therapeutics for SARS / cell differentiation / cytoskeleton / intracellular signal transduction / endosome / protein phosphorylation / innate immune response / ATP binding / plasma membrane / cytosol類似検索 - 分子機能 Tyrosine-protein kinase, non-receptor Jak3 / : / Tyrosine-protein kinase, non-receptor Jak/Tyk2 / JAK, FERM F2 lobe domain / FERM F1 lobe ubiquitin-like domain / JAK1-3/TYK2, pleckstrin homology-like domain / Jak1 pleckstrin homology-like domain / FERM F2 acyl-CoA binding protein-like domain / FERM F1 ubiquitin-like domain / FERM domain ...Tyrosine-protein kinase, non-receptor Jak3 / : / Tyrosine-protein kinase, non-receptor Jak/Tyk2 / JAK, FERM F2 lobe domain / FERM F1 lobe ubiquitin-like domain / JAK1-3/TYK2, pleckstrin homology-like domain / Jak1 pleckstrin homology-like domain / FERM F2 acyl-CoA binding protein-like domain / FERM F1 ubiquitin-like domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Src homology 2 domains / SH2 domain / SH2 domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / PH-like domain superfamily / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.33 Å |
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データ登録者 | Sack, J.S. |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2019 タイトル: Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. 著者: Spergel, S.H. / Mertzman, M.E. / Kempson, J. / Guo, J. / Stachura, S. / Haque, L. / Lippy, J.S. / Zhang, R.F. / Galella, M. / Pitt, S. / Shen, G. / Fura, A. / Gillooly, K. / McIntyre, K.W. / ...著者: Spergel, S.H. / Mertzman, M.E. / Kempson, J. / Guo, J. / Stachura, S. / Haque, L. / Lippy, J.S. / Zhang, R.F. / Galella, M. / Pitt, S. / Shen, G. / Fura, A. / Gillooly, K. / McIntyre, K.W. / Tang, V. / Tokarski, J. / Sack, J.S. / Khan, J. / Carter, P.H. / Barrish, J.C. / Nadler, S.G. / Salter-Cid, L.M. / Schieven, G.L. / Wrobleski, S.T. / Pitts, W.J. |
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履歴 | 登録 | 2019年2月11日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年5月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年3月13日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _diffrn_radiation_wavelength.wavelength |
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