登録情報 データベース : PDB / ID : 6nm4 構造の表示 ダウンロードとリンクタイトル Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor 要素Histone-lysine N-methyltransferase PRDM9 詳細 キーワード GENE REGULATION/INHIBITOR / PR SET domain / Lysine Methyltransferase / Inhibitor / Structural Genomics / Structural Genomics Consortium / SGC / GENE REGULATION-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
recombination hotspot binding / positive regulation of reciprocal meiotic recombination / positive regulation of fertilization / [histone H3]-lysine9 N-trimethyltransferase / male gamete generation / histone H4K20me methyltransferase activity / meiotic gene conversion / [histone H4]-N-methyl-L-lysine20 N-methyltransferase / histone H4K20 monomethyltransferase activity / histone H3K9 trimethyltransferase activity ... recombination hotspot binding / positive regulation of reciprocal meiotic recombination / positive regulation of fertilization / [histone H3]-lysine9 N-trimethyltransferase / male gamete generation / histone H4K20me methyltransferase activity / meiotic gene conversion / [histone H4]-N-methyl-L-lysine20 N-methyltransferase / histone H4K20 monomethyltransferase activity / histone H3K9 trimethyltransferase activity / [histone H4]-lysine20 N-methyltransferase / [histone H3]-lysine36 N-trimethyltransferase / female gamete generation / histone H3K36 trimethyltransferase activity / [histone H3]-lysine4 N-trimethyltransferase / double-strand break repair involved in meiotic recombination / homologous chromosome pairing at meiosis / histone H3K4 trimethyltransferase activity / histone H3K36 methyltransferase activity / histone H3K4 methyltransferase activity / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / PKMTs methylate histone lysines / Meiotic recombination / chromosome / regulation of gene expression / methylation / transcription cis-regulatory region binding / regulation of DNA-templated transcription / negative regulation of apoptotic process / protein homodimerization activity / zinc ion binding / nucleoplasm / nucleus 類似検索 - 分子機能 PRDM7/PRDM9, PR/SET domain / : / C2H2-type zinc finger / Ancestral KRAB domain / SSXRD motif / SSXRD motif / KRAB-related domain profile. / PR domain zinc finger protein 2, PR domain / KRAB box / krueppel associated box ... PRDM7/PRDM9, PR/SET domain / : / C2H2-type zinc finger / Ancestral KRAB domain / SSXRD motif / SSXRD motif / KRAB-related domain profile. / PR domain zinc finger protein 2, PR domain / KRAB box / krueppel associated box / Krueppel-associated box / KRAB domain superfamily / Beta-clip-like / SET domain / SET domain superfamily / SET domain profile. / SET domain / Zinc finger, C2H2 type / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Beta Complex / Mainly Beta 類似検索 - ドメイン・相同性 Chem-KS7 / S-ADENOSYLMETHIONINE / Histone-lysine N-methyltransferase PRDM9 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.58 Å 詳細データ登録者 Ivanochko, D. / Halabelian, L. / Fischer, C. / Sanders, J.M. / Kattar, S.D. / Brown, P.J. / Edwards, A.M. / Bountra, C. / Arrowsmith, C.H. / Structural Genomics Consortium (SGC) 引用ジャーナル : Nat Commun / 年 : 2019タイトル : Discovery of a chemical probe for PRDM9.著者: Allali-Hassani, A. / Szewczyk, M.M. / Ivanochko, D. / Organ, S.L. / Bok, J. / Ho, J.S.Y. / Gay, F.P.H. / Li, F. / Blazer, L. / Eram, M.S. / Halabelian, L. / Dilworth, D. / Luciani, G.M. / ... 著者 : Allali-Hassani, A. / Szewczyk, M.M. / Ivanochko, D. / Organ, S.L. / Bok, J. / Ho, J.S.Y. / Gay, F.P.H. / Li, F. / Blazer, L. / Eram, M.S. / Halabelian, L. / Dilworth, D. / Luciani, G.M. / Lima-Fernandes, E. / Wu, Q. / Loppnau, P. / Palmer, N. / Talib, S.Z.A. / Brown, P.J. / Schapira, M. / Kaldis, P. / O'Hagan, R.C. / Guccione, E. / Barsyte-Lovejoy, D. / Arrowsmith, C.H. / Sanders, J.M. / Kattar, S.D. / Bennett, D.J. / Nicholson, B. / Vedadi, M. 履歴 登録 2019年1月10日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2019年2月13日 Provider : repository / タイプ : Initial release改定 1.1 2019年12月25日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2023年10月11日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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