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- PDB-6mom: Crystal structure of human Interleukin-1 receptor associated Kina... -
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Basic information
Entry | Database: PDB / ID: 6mom | ||||||
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Title | Crystal structure of human Interleukin-1 receptor associated Kinase 4 (IRAK 4, CID 100300) in complex with compound NCC00371481 (BSI 107591) | ||||||
![]() | Interleukin-1 receptor-associated kinase 4 | ||||||
![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Interleukin-1 receptor associated Kinase 4 / CID 100300 / NCC00371481 / BSI 107591 / Beryllium / TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||
Function / homology | ![]() IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding ...IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding / MyD88-dependent toll-like receptor signaling pathway / interleukin-1-mediated signaling pathway / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor 4 signaling pathway / toll-like receptor signaling pathway / extrinsic component of plasma membrane / JNK cascade / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / positive regulation of smooth muscle cell proliferation / cytokine-mediated signaling pathway / Interleukin-1 signaling / PIP3 activates AKT signaling / kinase activity / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / cellular response to lipopolysaccharide / positive regulation of canonical NF-kappaB signal transduction / endosome membrane / non-specific serine/threonine protein kinase / intracellular signal transduction / phosphorylation / innate immune response / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / cell surface / magnesium ion binding / extracellular space / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Abendroth, J. / Mayclin, S.J. / Lorimer, D.D. / Starczynowski, D. / Hoyt, S. / Tawa, G. / Thomas, C. | ||||||
![]() | ![]() Title: Overcoming adaptive therapy resistance in AML by targeting immune response pathways. Authors: Melgar, K. / Walker, M.M. / Jones, L.M. / Bolanos, L.C. / Hueneman, K. / Wunderlich, M. / Jiang, J.K. / Wilson, K.M. / Zhang, X. / Sutter, P. / Wang, A. / Xu, X. / Choi, K. / Tawa, G. / ...Authors: Melgar, K. / Walker, M.M. / Jones, L.M. / Bolanos, L.C. / Hueneman, K. / Wunderlich, M. / Jiang, J.K. / Wilson, K.M. / Zhang, X. / Sutter, P. / Wang, A. / Xu, X. / Choi, K. / Tawa, G. / Lorimer, D. / Abendroth, J. / O'Brien, E. / Hoyt, S.B. / Berman, E. / Famulare, C.A. / Mulloy, J.C. / Levine, R.L. / Perentesis, J.P. / Thomas, C.J. / Starczynowski, D.T. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 495.3 KB | Display | ![]() |
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PDB format | ![]() | 406 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 1.7 MB | Display | ![]() |
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Full document | ![]() | 1.7 MB | Display | |
Data in XML | ![]() | 55.4 KB | Display | |
Data in CIF | ![]() | 80.3 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2nruS S: Starting model for refinement |
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Similar structure data |
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Assembly
Deposited unit | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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