登録情報 | データベース: PDB / ID: 6m9t |
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タイトル | Crystal structure of EP3 receptor bound to misoprostol-FA |
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要素 | Prostaglandin E2 receptor EP3 subtype, Endolysin chimera |
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キーワード | MEMBRANE PROTEIN / GPCR / prostaglandin E2 receptor 3 (EP3) / prostaglandin analogue / misoprostol-FA (biologically active free acid) / XFEL / LCP / T4L |
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機能・相同性 | 機能・相同性情報
negative regulation of gastric acid secretion / intestine smooth muscle contraction / prostaglandin E receptor activity / Prostanoid ligand receptors / cell death / positive regulation of fever generation / viral release from host cell by cytolysis / peptidoglycan catabolic process / adenylate cyclase-activating G protein-coupled receptor signaling pathway / cell wall macromolecule catabolic process ...negative regulation of gastric acid secretion / intestine smooth muscle contraction / prostaglandin E receptor activity / Prostanoid ligand receptors / cell death / positive regulation of fever generation / viral release from host cell by cytolysis / peptidoglycan catabolic process / adenylate cyclase-activating G protein-coupled receptor signaling pathway / cell wall macromolecule catabolic process / lysozyme / lysozyme activity / nuclear envelope / phospholipase C-activating G protein-coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / G alpha (i) signalling events / host cell cytoplasm / defense response to bacterium / inflammatory response / G protein-coupled receptor signaling pathway / membrane / plasma membrane類似検索 - 分子機能 Prostanoid EP3 receptor / Prostanoid EP3 receptor, type 2 / Prostaglandin DP receptor / Prostanoid receptor / : / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme ...Prostanoid EP3 receptor / Prostanoid EP3 receptor, type 2 / Prostaglandin DP receptor / Prostanoid receptor / : / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Lysozyme-like domain superfamily類似検索 - ドメイン・相同性 Chem-J9P / OLEIC ACID / (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / Endolysin / Prostaglandin E2 receptor EP3 subtype類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
Enterobacteria phage T4 (ファージ) |
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手法 | X線回折 / 自由電子レーザー / 分子置換 / 解像度: 2.5 Å |
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データ登録者 | Audet, M. / White, K.L. / Breton, B. / Zarzycka, B. / Han, G.W. / Lu, Y. / Gati, C. / Batyuk, A. / Popov, P. / Velasquez, J. ...Audet, M. / White, K.L. / Breton, B. / Zarzycka, B. / Han, G.W. / Lu, Y. / Gati, C. / Batyuk, A. / Popov, P. / Velasquez, J. / Manahan, D. / Hu, H. / Weierstall, U. / Liu, W. / Shui, W. / Katrich, V. / Cherezov, V. / Hanson, M.A. / Stevens, R.C. |
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引用 | ジャーナル: Nat. Chem. Biol. / 年: 2019 タイトル: Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor. 著者: Audet, M. / White, K.L. / Breton, B. / Zarzycka, B. / Han, G.W. / Lu, Y. / Gati, C. / Batyuk, A. / Popov, P. / Velasquez, J. / Manahan, D. / Hu, H. / Weierstall, U. / Liu, W. / Shui, W. / ...著者: Audet, M. / White, K.L. / Breton, B. / Zarzycka, B. / Han, G.W. / Lu, Y. / Gati, C. / Batyuk, A. / Popov, P. / Velasquez, J. / Manahan, D. / Hu, H. / Weierstall, U. / Liu, W. / Shui, W. / Katritch, V. / Cherezov, V. / Hanson, M.A. / Stevens, R.C. |
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履歴 | 登録 | 2018年8月24日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年12月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年2月13日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_volume ..._citation.journal_abbrev / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2020年4月29日 | Group: Data collection / カテゴリ: diffrn_source Item: _diffrn_source.pdbx_synchrotron_beamline / _diffrn_source.pdbx_synchrotron_site |
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改定 1.3 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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