登録情報 | データベース: PDB / ID: 6h3e |
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タイトル | Receptor-bound Ghrelin conformation |
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要素 | Appetite-regulating hormone |
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キーワード | HORMONE / Neuropeptide / acyl chain / growth hormone secretagogue receptor / GPCR / lipopeptide hormone / obesity / diabetes / addiction. |
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機能・相同性 | 機能・相同性情報
ghrelin receptor binding / positive regulation of bone development / positive regulation of gastric mucosal blood circulation / negative regulation of locomotion / cortisol secretion / positive regulation of small intestinal transit / growth hormone-releasing hormone activity / negative regulation of circadian sleep/wake cycle, REM sleep / positive regulation of circadian sleep/wake cycle, non-REM sleep / regulation of response to food ...ghrelin receptor binding / positive regulation of bone development / positive regulation of gastric mucosal blood circulation / negative regulation of locomotion / cortisol secretion / positive regulation of small intestinal transit / growth hormone-releasing hormone activity / negative regulation of circadian sleep/wake cycle, REM sleep / positive regulation of circadian sleep/wake cycle, non-REM sleep / regulation of response to food / regulation of gastric motility / regulation of transmission of nerve impulse / gastric acid secretion / positive regulation of corticotropin secretion / positive regulation of cortisol secretion / growth hormone secretion / positive regulation of growth rate / positive regulation of eating behavior / positive regulation of small intestine smooth muscle contraction / positive regulation of appetite / adult feeding behavior / positive regulation of growth hormone secretion / protein tyrosine kinase activator activity / positive regulation of growth hormone receptor signaling pathway / positive regulation of multicellular organism growth / actin polymerization or depolymerization / positive regulation of synapse assembly / cartilage development / negative regulation of interleukin-1 beta production / positive regulation of vascular endothelial cell proliferation / regulation of postsynapse organization / postsynaptic modulation of chemical synaptic transmission / positive regulation of sprouting angiogenesis / dendrite development / negative regulation of endothelial cell proliferation / positive regulation of insulin secretion involved in cellular response to glucose stimulus / negative regulation of interleukin-6 production / negative regulation of tumor necrosis factor production / decidualization / Synthesis, secretion, and deacylation of Ghrelin / positive regulation of adipose tissue development / negative regulation of insulin secretion / hormone-mediated signaling pathway / negative regulation of angiogenesis / response to electrical stimulus / synapse assembly / Peptide ligand-binding receptors / excitatory postsynaptic potential / response to hormone / G protein-coupled receptor binding / negative regulation of inflammatory response / positive regulation of insulin secretion / Schaffer collateral - CA1 synapse / response to estrogen / glucose metabolic process / positive regulation of cold-induced thermogenesis / regulation of cell population proliferation / positive regulation of cytosolic calcium ion concentration / G alpha (q) signalling events / secretory granule lumen / postsynapse / positive regulation of MAPK cascade / G protein-coupled receptor signaling pathway / endoplasmic reticulum lumen / axon / glutamatergic synapse / negative regulation of apoptotic process / extracellular space / extracellular region類似検索 - 分子機能 Preproghrelin peptide / Motilin/ghrelin-associated peptide / Motilin/ghrelin / Motilin/ghrelin-associated peptide / Motilin/ghrelin類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / molecular dynamics |
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データ登録者 | Ferre, G. / Damian, M. / M'Kadmi, C. / Saurel, O. / Czaplicki, G. / Demange, P. / Marie, J. / Fehrentz, J.A. / Baneres, J.L. / Milon, A. |
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資金援助 | フランス, 1件 組織 | 認可番号 | 国 |
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French National Research Agency | ANR-17-CE11-0011-03 | フランス |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2019 タイトル: Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain. 著者: Ferre, G. / Louet, M. / Saurel, O. / Delort, B. / Czaplicki, G. / M'Kadmi, C. / Damian, M. / Renault, P. / Cantel, S. / Gavara, L. / Demange, P. / Marie, J. / Fehrentz, J.A. / Floquet, N. / ...著者: Ferre, G. / Louet, M. / Saurel, O. / Delort, B. / Czaplicki, G. / M'Kadmi, C. / Damian, M. / Renault, P. / Cantel, S. / Gavara, L. / Demange, P. / Marie, J. / Fehrentz, J.A. / Floquet, N. / Milon, A. / Baneres, J.L. |
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履歴 | 登録 | 2018年7月18日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年7月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年8月21日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.title / _citation.year |
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改定 1.2 | 2019年8月28日 | Group: Data collection / Database references / カテゴリ: citation / citation_author / Item: _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.3 | 2019年9月4日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.4 | 2023年6月14日 | Group: Database references / Other / カテゴリ: database_2 / pdbx_database_status Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data |
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