Entry Database : PDB / ID : 6fdz Structure visualization Downloads & linksTitle Unc-51-Like Kinase 3 (ULK3) In Complex With Momelotinib ComponentsSerine/threonine-protein kinase ULK3 Details Keywords TRANSFERASE / Kinase Inhibitor DFG-outFunction / homology Function and homology informationFunction Domain/homology Component
ciliary tip / phagophore assembly site membrane / fibroblast activation / piecemeal microautophagy of the nucleus / positive regulation of smoothened signaling pathway / phagophore assembly site / reticulophagy / smoothened signaling pathway / response to starvation / autophagosome assembly ... ciliary tip / phagophore assembly site membrane / fibroblast activation / piecemeal microautophagy of the nucleus / positive regulation of smoothened signaling pathway / phagophore assembly site / reticulophagy / smoothened signaling pathway / response to starvation / autophagosome assembly / autophagosome / negative regulation of smoothened signaling pathway / regulation of autophagy / Hedgehog 'on' state / autophagy / cellular senescence / protein autophosphorylation / non-specific serine/threonine protein kinase / protein serine kinase activity / protein serine/threonine kinase activity / ATP binding / cytosol / cytoplasm Similarity search - Function Serine/threonine-protein kinase Atg1-like / MIT (microtubule interacting and transport) domain / MIT domain superfamily / MIT domain / Microtubule Interacting and Trafficking molecule domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site ... Serine/threonine-protein kinase Atg1-like / MIT (microtubule interacting and transport) domain / MIT domain superfamily / MIT domain / Microtubule Interacting and Trafficking molecule domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.55 Å DetailsAuthors Mathea, S. / Salah, E. / Moroglu, M. / Scorah, A. / Pike, A.C.W. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Huber, K. / Knapp, S. CitationJournal : To Be Published Title : Unc-51-Like Kinase 3 (ULK3) In Complex With MomelotinibAuthors : Mathea, S. / Salah, E. / Moroglu, M. / Scorah, A. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Huber, K. / Knapp, S. History Deposition Dec 27, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Aug 1, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less