Entry Database : PDB / ID : 6ek3 Structure visualization Downloads & linksTitle PARP15 CATALYTIC DOMAIN MUTANT (Y598L) IN COMPLEX WITH OUL35 ComponentsPoly [ADP-ribose] polymerase 15 Details Keywords TRANSFERASE / Inhibitor / OUL35 / SIGNALING PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
protein poly-ADP-ribosylation / NAD+-protein ADP-ribosyltransferase activity / NAD+-protein poly-ADP-ribosyltransferase activity / Transferases; Glycosyltransferases; Pentosyltransferases / NAD+ binding / nucleotidyltransferase activity / transcription corepressor activity / negative regulation of gene expression / negative regulation of transcription by RNA polymerase II / nucleus / cytoplasm Similarity search - Function : / Phosphoenolpyruvate Carboxykinase; domain 3 - #10 / Phosphoenolpyruvate Carboxykinase; domain 3 / Poly(ADP-ribose) polymerase catalytic domain / Poly(ADP-ribose) polymerase, catalytic domain / PARP catalytic domain profile. / Macro domain / Appr-1"-p processing enzyme / Macro domain / Macro domain profile. ... : / Phosphoenolpyruvate Carboxykinase; domain 3 - #10 / Phosphoenolpyruvate Carboxykinase; domain 3 / Poly(ADP-ribose) polymerase catalytic domain / Poly(ADP-ribose) polymerase, catalytic domain / PARP catalytic domain profile. / Macro domain / Appr-1"-p processing enzyme / Macro domain / Macro domain profile. / Macro domain-like / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.6 Å DetailsAuthors Maksimainen, M.M. / Lehtio, L. Funding support Finland, 2items Details Hide detailsOrganization Grant number Country Academy of Finland 287063 Finland Academy of Finland 294085 Finland
CitationJournal : Eur J Med Chem / Year : 2018Title : 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10.Authors : Murthy, S. / Desantis, J. / Verheugd, P. / Maksimainen, M.M. / Venkannagari, H. / Massari, S. / Ashok, Y. / Obaji, E. / Nkizinkinko, Y. / Luscher, B. / Tabarrini, O. / Lehtio, L. History Deposition Sep 25, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jul 25, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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