Entry Database : PDB / ID : 6dxk Structure visualization Downloads & linksTitle Glucocorticoid Receptor in complex with Compound 11 ComponentsGlucocorticoid receptor Details Keywords TRANSCRIPTION / SIGNALING PROTEIN / NUCLEAR HORMONE RECEPTOR / LIGAND COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
Regulation of NPAS4 gene transcription / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / steroid hormone binding / glucocorticoid metabolic process / response to cortisol / PTK6 Expression / neuroinflammatory response / mammary gland duct morphogenesis / microglia differentiation ... Regulation of NPAS4 gene transcription / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / steroid hormone binding / glucocorticoid metabolic process / response to cortisol / PTK6 Expression / neuroinflammatory response / mammary gland duct morphogenesis / microglia differentiation / maternal behavior / astrocyte differentiation / motor behavior / regulation of gluconeogenesis / adrenal gland development / cellular response to glucocorticoid stimulus / cellular response to steroid hormone stimulus / estrogen response element binding / nuclear receptor-mediated steroid hormone signaling pathway / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / core promoter sequence-specific DNA binding / cellular response to transforming growth factor beta stimulus / steroid binding / cellular response to dexamethasone stimulus / TBP-class protein binding / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / synaptic transmission, glutamatergic / chromosome segregation / RNA polymerase II transcription regulatory region sequence-specific DNA binding / SUMOylation of intracellular receptors / Hsp90 protein binding / promoter-specific chromatin binding / Nuclear Receptor transcription pathway / positive regulation of miRNA transcription / response to wounding / DNA-binding transcription repressor activity, RNA polymerase II-specific / spindle / nuclear receptor activity / Regulation of RUNX2 expression and activity / sequence-specific double-stranded DNA binding / positive regulation of neuron apoptotic process / : / chromatin organization / DNA-binding transcription activator activity, RNA polymerase II-specific / gene expression / Potential therapeutics for SARS / DNA-binding transcription factor activity, RNA polymerase II-specific / nuclear speck / mitochondrial matrix / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / cell division / negative regulation of DNA-templated transcription / apoptotic process / synapse / centrosome / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / protein kinase binding / chromatin / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / RNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus / membrane / cytosol / cytoplasm Similarity search - Function Glucocorticoid receptor / Glucocorticoid receptor / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Double treble clef zinc finger, C4 type / Nuclear hormone receptors DNA-binding domain profile. ... Glucocorticoid receptor / Glucocorticoid receptor / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Double treble clef zinc finger, C4 type / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.05 Å DetailsAuthors Rew, Y. / Du, X. / Eksterowicz, J. / Zhou, H. / Jahchan, N. / Zhu, L. / Yan, X. / Kawai, H. / McGee, L.R. / Medina, J.C. ...Rew, Y. / Du, X. / Eksterowicz, J. / Zhou, H. / Jahchan, N. / Zhu, L. / Yan, X. / Kawai, H. / McGee, L.R. / Medina, J.C. / Huang, T. / Chen, C. / Zavorotinskaya, T. / Sutimantanapi, D. / Waszczuk, J. / Jackson, E. / Huang, E. / Ye, Q. / Fantin, V.R. / Daqing, S. CitationJournal : J. Med. Chem. / Year : 2018Title : Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).Authors: Rew, Y. / Du, X. / Eksterowicz, J. / Zhou, H. / Jahchan, N. / Zhu, L. / Yan, X. / Kawai, H. / McGee, L.R. / Medina, J.C. / Huang, T. / Chen, C. / Zavorotinskaya, T. / Sutimantanapi, D. / ... Authors : Rew, Y. / Du, X. / Eksterowicz, J. / Zhou, H. / Jahchan, N. / Zhu, L. / Yan, X. / Kawai, H. / McGee, L.R. / Medina, J.C. / Huang, T. / Chen, C. / Zavorotinskaya, T. / Sutimantanapi, D. / Waszczuk, J. / Jackson, E. / Huang, E. / Ye, Q. / Fantin, V.R. / Sun, D. History Deposition Jun 29, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 3, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Oct 11, 2023 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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