登録情報 | データベース: PDB / ID: 6dup |
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タイトル | CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH COMPOUND 7 |
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要素 | Nuclear receptor subfamily 1 group I member 2 |
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キーワード | NUCLEAR PROTEIN / PXR |
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機能・相同性 | 機能・相同性情報
xenobiotic transport / intermediate filament cytoskeleton / steroid metabolic process / xenobiotic catabolic process / xenobiotic metabolic process / nuclear receptor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / SUMOylation of intracellular receptors / Nuclear Receptor transcription pathway / nuclear receptor activity ...xenobiotic transport / intermediate filament cytoskeleton / steroid metabolic process / xenobiotic catabolic process / xenobiotic metabolic process / nuclear receptor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / SUMOylation of intracellular receptors / Nuclear Receptor transcription pathway / nuclear receptor activity / sequence-specific double-stranded DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / transcription regulator complex / cell differentiation / nuclear body / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of DNA-templated transcription / positive regulation of gene expression / regulation of DNA-templated transcription / chromatin / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm類似検索 - 分子機能 Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily ...Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-HCJ / Nuclear receptor subfamily 1 group I member 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.3 Å |
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データ登録者 | Chen, X. / Zhang, Y. / Mclean, L.R. |
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引用 | ジャーナル: Bioorg. Med. Chem. Lett. / 年: 2018 タイトル: Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators. 著者: Vaz, R.J. / Li, Y. / Chellaraj, V. / Reiling, S. / Kuntzweiler, T. / Yang, D. / Shen, H. / Batchelor, J.D. / Zhang, Y. / Chen, X. / McLean, L.R. / Kosley Jr., R. |
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履歴 | 登録 | 2018年6月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年8月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年9月12日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_abbrev / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2018年10月17日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年3月13日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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