登録情報 データベース : PDB / ID : 5ygx 構造の表示 ダウンロードとリンクタイトル Structure of BACE1 in complex with N-(3-((4R,5R,6S)-2-amino-6-(1,1-difluoroethyl)-5-fluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide 要素Beta-secretase 1 詳細 キーワード HYDROLASE/INHIBITOR / beta secretase / HYDROLASE-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / detection of mechanical stimulus involved in sensory perception of pain / cellular response to manganese ion / amyloid-beta metabolic process ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / detection of mechanical stimulus involved in sensory perception of pain / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / positive regulation of neuron apoptotic process / cellular response to amyloid-beta / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / lysosome / early endosome / aspartic-type endopeptidase activity / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Nakahara, K. / Fuchino, K. / Komano, K. / Asada, N. / Tadano, G. / Hasegawa, T. / Yamamoto, T. / Sako, Y. / Ogawa, M. / Unemura, C. ...Nakahara, K. / Fuchino, K. / Komano, K. / Asada, N. / Tadano, G. / Hasegawa, T. / Yamamoto, T. / Sako, Y. / Ogawa, M. / Unemura, C. / Hosono, M. / Sakaguchi, G. / Ando, S. / Ohnishi, S. / Kido, Y. / Fukushima, T. / Dhuyvetter, D. / Borghys, H. / Gijsen, H. / Yamano, Y. / Iso, Y. / Kusakabe, K. 引用ジャーナル : J. Med. Chem. / 年 : 2018タイトル : Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine beta-Secretase (BACE1) Inhibitors via Active Conformation Stabilization著者: Nakahara, K. / Fuchino, K. / Komano, K. / Asada, N. / Tadano, G. / Hasegawa, T. / Yamamoto, T. / Sako, Y. / Ogawa, M. / Unemura, C. / Hosono, M. / Ito, H. / Sakaguchi, G. / Ando, S. / ... 著者 : Nakahara, K. / Fuchino, K. / Komano, K. / Asada, N. / Tadano, G. / Hasegawa, T. / Yamamoto, T. / Sako, Y. / Ogawa, M. / Unemura, C. / Hosono, M. / Ito, H. / Sakaguchi, G. / Ando, S. / Ohnishi, S. / Kido, Y. / Fukushima, T. / Dhuyvetter, D. / Borghys, H. / Gijsen, H.J.M. / Yamano, Y. / Iso, Y. / Kusakabe, K.I. 履歴 登録 2017年9月27日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2018年8月8日 Provider : repository / タイプ : Initial release改定 1.1 2023年11月22日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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