登録情報 | データベース: PDB / ID: 5vfc |
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タイトル | WDR5 bound to inhibitor MM-589 |
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要素 | WD repeat-containing protein 5 |
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キーワード | TRANSCRIPTION/INHIBITOR / inhibitor / complex / WD repeat / TRANSCRIPTION / TRANSCRIPTION-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
MLL3/4 complex / Set1C/COMPASS complex / MLL1/2 complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / Cardiogenesis / regulation of tubulin deacetylation / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes ...MLL3/4 complex / Set1C/COMPASS complex / MLL1/2 complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / Cardiogenesis / regulation of tubulin deacetylation / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / regulation of cell division / regulation of embryonic development / MLL1 complex / histone acetyltransferase complex / positive regulation of gluconeogenesis / methylated histone binding / transcription initiation-coupled chromatin remodeling / skeletal system development / gluconeogenesis / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / PKMTs methylate histone lysines / RMTs methylate histone arginines / mitotic spindle / Activation of anterior HOX genes in hindbrain development during early embryogenesis / Neddylation / HATs acetylate histones / histone binding / regulation of cell cycle / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats ...YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Mainly Beta類似検索 - ドメイン・相同性 inhibitor MM-589 / Chem-9BA / WD repeat-containing protein 5類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 1.64 Å |
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データ登録者 | Stuckey, J.A. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | CA177307 | 米国 |
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引用 | ジャーナル: J. Med. Chem. / 年: 2017 タイトル: Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. 著者: Karatas, H. / Li, Y. / Liu, L. / Ji, J. / Lee, S. / Chen, Y. / Yang, J. / Huang, L. / Bernard, D. / Xu, J. / Townsend, E.C. / Cao, F. / Ran, X. / Li, X. / Wen, B. / Sun, D. / Stuckey, J.A. / ...著者: Karatas, H. / Li, Y. / Liu, L. / Ji, J. / Lee, S. / Chen, Y. / Yang, J. / Huang, L. / Bernard, D. / Xu, J. / Townsend, E.C. / Cao, F. / Ran, X. / Li, X. / Wen, B. / Sun, D. / Stuckey, J.A. / Lei, M. / Dou, Y. / Wang, S. |
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履歴 | 登録 | 2017年4月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年6月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年7月5日 | Group: Database references / カテゴリ: citation Item: _citation.country / _citation.journal_id_ASTM ..._citation.country / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.2 | 2017年9月20日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2019年12月4日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2024年3月13日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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