登録情報 | データベース: PDB / ID: 5uew |
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タイトル | BRD2 Bromodomain2 with A-1360579 |
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要素 | Bromodomain-containing protein 2 |
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キーワード | SIGNALING PROTEIN/INHIBITOR / SIGNALING PROTEIN-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck ...acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck / protein serine/threonine kinase activity / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site ...: / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 1.83 Å |
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データ登録者 | Park, C.H. |
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引用 | ジャーナル: J. Med. Chem. / 年: 2017 タイトル: Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors. 著者: Wang, L. / Pratt, J.K. / Soltwedel, T. / Sheppard, G.S. / Fidanze, S.D. / Liu, D. / Hasvold, L.A. / Mantei, R.A. / Holms, J.H. / McClellan, W.J. / Wendt, M.D. / Wada, C. / Frey, R. / Hansen, ...著者: Wang, L. / Pratt, J.K. / Soltwedel, T. / Sheppard, G.S. / Fidanze, S.D. / Liu, D. / Hasvold, L.A. / Mantei, R.A. / Holms, J.H. / McClellan, W.J. / Wendt, M.D. / Wada, C. / Frey, R. / Hansen, T.M. / Hubbard, R. / Park, C.H. / Li, L. / Magoc, T.J. / Albert, D.H. / Lin, X. / Warder, S.E. / Kovar, P. / Huang, X. / Wilcox, D. / Wang, R. / Rajaraman, G. / Petros, A.M. / Hutchins, C.W. / Panchal, S.C. / Sun, C. / Elmore, S.W. / Shen, Y. / Kati, W.M. / McDaniel, K.F. |
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履歴 | 登録 | 2017年1月3日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年5月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年5月24日 | Group: Database references |
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改定 1.2 | 2024年3月6日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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