登録情報 データベース : PDB / ID : 5tvc 構造の表示 ダウンロードとリンクタイトル Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312) 要素Soluble acetylcholine receptor,Neuronal acetylcholine receptor subunit alpha-3 chimera 詳細 キーワード ACETYLCHOLINE-BINDING PROTEIN / nicotinic / acetylcholine / AChBP / chimeric protein機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of acetylcholine secretion, neurotransmission / synaptic transmission involved in micturition / Highly sodium permeable postsynaptic acetylcholine nicotinic receptors / Highly calcium permeable nicotinic acetylcholine receptors / response to acetylcholine / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / acetylcholine-gated channel complex / regulation of smooth muscle contraction / behavioral response to nicotine / acetylcholine receptor activity ... regulation of acetylcholine secretion, neurotransmission / synaptic transmission involved in micturition / Highly sodium permeable postsynaptic acetylcholine nicotinic receptors / Highly calcium permeable nicotinic acetylcholine receptors / response to acetylcholine / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / acetylcholine-gated channel complex / regulation of smooth muscle contraction / behavioral response to nicotine / acetylcholine receptor activity / synaptic transmission, cholinergic / acetylcholine binding / acetylcholine-gated monoatomic cation-selective channel activity / acetylcholine receptor signaling pathway / activation of transmembrane receptor protein tyrosine kinase activity / regulation of dendrite morphogenesis / plasma membrane raft / membrane depolarization / ligand-gated monoatomic ion channel activity / monoatomic ion transport / regulation of membrane potential / excitatory postsynaptic potential / locomotory behavior / response to nicotine / nervous system development / postsynaptic membrane / postsynapse / postsynaptic density / nuclear speck / neuron projection / neuronal cell body / synapse / dendrite / Golgi apparatus / signal transduction / endoplasmic reticulum / identical protein binding / membrane / metal ion binding / plasma membrane 類似検索 - 分子機能 Nicotinic acetylcholine receptor / Acetylcholine Binding Protein; Chain: A, / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel, conserved site / Neurotransmitter-gated ion-channels signature. / Neurotransmitter-gated ion-channel transmembrane domain / Neurotransmitter-gated ion-channel transmembrane region / Neurotransmitter-gated ion-channel transmembrane domain superfamily / Neuronal acetylcholine receptor / Neurotransmitter-gated ion-channel ... Nicotinic acetylcholine receptor / Acetylcholine Binding Protein; Chain: A, / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel, conserved site / Neurotransmitter-gated ion-channels signature. / Neurotransmitter-gated ion-channel transmembrane domain / Neurotransmitter-gated ion-channel transmembrane region / Neurotransmitter-gated ion-channel transmembrane domain superfamily / Neuronal acetylcholine receptor / Neurotransmitter-gated ion-channel / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel ligand-binding domain superfamily / Neurotransmitter-gated ion-channel ligand binding domain / Distorted Sandwich / Mainly Beta 類似検索 - ドメイン・相同性 Chem-7LB / Neuronal acetylcholine receptor subunit alpha-3 / Soluble acetylcholine receptor 類似検索 - 構成要素生物種 Aplysia californica (無脊椎動物)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.926 Å 詳細データ登録者 Bobango, J. / Wu, J. / Talley, I.T. / Talley, T.T. 引用ジャーナル : To Be Published タイトル: Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex ... タイトル : Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)著者 : Bobango, J. / Wu, J. / Talley, I.T. / Talley, T.T. 履歴 登録 2016年11月8日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年11月30日 Provider : repository / タイプ : Initial release改定 1.1 2017年11月22日 Group : Refinement description / カテゴリ : software / Item : _software.name改定 1.2 2023年10月4日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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