Entry Database : PDB / ID : 5cqg Structure visualization Downloads & linksTitle Structure of Tribolium telomerase in complex with the highly specific inhibitor BIBR1532 ComponentsTelomerase reverse transcriptase Details Keywords Transferase/Transferase inhibitor / Telomerase Reverse transcriptase fold TERT BIBR15312 / Telomerase Inhibitor / Transferase-Transferase inhibitor complexFunction / homology Function and homology informationFunction Domain/homology Component
Arc Repressor Mutant, subunit A - #2210 / Telomerase reverse transcriptase (TERT), thumb domain / HIV Type 1 Reverse Transcriptase; Chain A, domain 1 - #20 / Alpha-Beta Plaits - #2630 / Telomerase reverse transcriptase, thumb DNA-binding domain / Telomerase reverse transcriptase thumb DNA binding domain / Topoisomerase I; Chain A, domain 4 - #70 / Telomerase reverse transcriptase / Telomerase ribonucleoprotein complex - RNA-binding domain / Telomerase ribonucleoprotein complex - RNA binding domain ... Arc Repressor Mutant, subunit A - #2210 / Telomerase reverse transcriptase (TERT), thumb domain / HIV Type 1 Reverse Transcriptase; Chain A, domain 1 - #20 / Alpha-Beta Plaits - #2630 / Telomerase reverse transcriptase, thumb DNA-binding domain / Telomerase reverse transcriptase thumb DNA binding domain / Topoisomerase I; Chain A, domain 4 - #70 / Telomerase reverse transcriptase / Telomerase ribonucleoprotein complex - RNA-binding domain / Telomerase ribonucleoprotein complex - RNA binding domain / Topoisomerase I; Chain A, domain 4 / HIV Type 1 Reverse Transcriptase; Chain A, domain 1 / Tetracycline Repressor; domain 2 / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Arc Repressor Mutant, subunit A / Alpha-Beta Plaits / Roll / DNA/RNA polymerase superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Tribolium castaneum (red flour beetle)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.3 Å DetailsAuthors Bryan, C. / Rice, C. / Hoffman, H. / Harkisheimer, M. / Sweeney, M. / Skordalakes, E. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM088332 United States
CitationJournal : Structure / Year : 2015Title : Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532.Authors : Bryan, C. / Rice, C. / Hoffman, H. / Harkisheimer, M. / Sweeney, M. / Skordalakes, E. History Deposition Jul 21, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Sep 9, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Sep 13, 2017 Group : Author supporting evidence / Derived calculations / Category : pdbx_audit_support / pdbx_struct_oper_listItem : _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operationRevision 1.2 Oct 10, 2018 Group : Data collection / Database references / Structure summaryCategory : citation / entityItem : _citation.journal_id_ISSN / _citation.page_first ... _citation.journal_id_ISSN / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _entity.formula_weight Revision 1.3 Dec 25, 2019 Group : Author supporting evidence / Structure summary / Category : entity / pdbx_audit_supportItem : _entity.formula_weight / _pdbx_audit_support.funding_organizationRevision 1.4 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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